DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and tdrd7a

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001092813.1	Gene:	tdrd7a / 406379	ZFINID:	ZDB-GENE-040426-2103	Length:	1079	Species:	Danio rerio

Alignment Length:	936	Identity:	176/936 - (18%)
Similarity:	292/936 - (31%)	Gaps:	340/936 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LEDISMIMKL----FDSNMH-----KLQGNLRSYQTEM-------HQIHKELTEKLSHADLLYRS 51
            :.|:.::.|:    ..|:.|     :|||:.|:...||       |...:.....:.....|.||
Zfish     1 MSDVELVKKMLRAVLQSSKHGVAMARLQGDYRALTGEMIPFRKFGHDTLESFLRSIPGVVRLERS 65

  Fly    52 LIPLHDHLVASLSEVNAHVMK----------------LNVQL-----HINRQSV--RLGDYEYYE 93
             |.......|.:.|..||:.:                ||.|:     |:...:|  ||
Zfish    66 -IAGEVMCFAGVCEETAHIAQLVARQKNVKKTGCSKLLNFQMRTRTSHLFSHNVKPRL------- 122

  Fly    94 KSIDNPYSSIRSGLQAIEKPGCAEAICQSSKPAFVECLPSSTSEEVPVVAVQEASSTNQLDAI-- 156
             |:..|.:....|      .|...:...:.:..:...||||   ..|...:...|...:..::
Zfish   123 -SLRQPSNMTHPG------RGSVTSFYSTQRKLYSTDLPSS---RAPAWQMNRKSPVPEKTSVVP 177

  Fly   157 SVVNENLS---EERDATP-QPLAVSKNMEETMP-----------------------SNPFHEQLE 194
            |.:|.|:.   ::...|| |...|::...|.:.                       .:.|.|:|.
Zfish   178 SKINTNIKTPLKKTSGTPAQQKPVNRADVELVQGRIKQLLQKYSSGVWLSKIPQLYKSMFQEELH 242

  Fly   195 GSLEEIPVGSKI-VVETEKANN-----------PVRSEASAPA-----TSDNQSLLAAKQGTQTI 242
             .::|:...:.| .||...:||           ||...:..|.     .|.|.:||  ||.|.|
Zfish   243 -IIQEVEKWTHICTVEKPGSNNIVDRLVYPVLEPVPKASPVPVKSPCKQSPNTALL--KQPTLT- 303

  Fly   243 GTGICNKISKS----TINMPNNWQLENPTEVTAASIEKVNK------LPKSPRNRFL-------L 290
                 .|.:::    .||:|.:    .|...|..|....|.      |.::|:.:.|       .
Zfish   304 -----QKTTRTFRTLAINIPQS----TPKPQTPLSPTSPNSTMMDFTLSETPKTQSLSPITPPST 359

  Fly   291 PPKGGTETTR-----RDIYNQILKDM--------------AAFPENTIVTAVLASVDVTDNCAYV 336
            ||.....||.     |.:.|:..:.:              .|||:..:....|    :.|.|  :
Zfish   360 PPAHQPLTTELKQKLRQLLNKYSQGLWAHGLPQLFQEAFGCAFPQYVLEDLSL----LADTC--M 418

  Fly   337 AKWDESSDRIKKVLQRQLPLQELDQ---------LP---------------DYGDIFAV-LDSIN 376
            .::....:| |:.:...||.|...|         ||               |:..:|.: ::|.|
Zfish   419 VEYPMPDNR-KRAILYTLPCQVQTQPRSRPPPLVLPCTSNPHVPPLIIPTADFHSVFVIEINSTN 482

  Fly   377 NIITRITINSSSAGGGY------------------------------------------------ 393
            |::.|.      ||.||
Zfish   483 NVVVRF------AGEGYSKSLEVMEEEMQNFYNNIGAGLCLLSPKIGQLVAVASSDGAMLRAQVH 541

  Fly   394 ----DAYLIDFGEHIHFD--GNETIFKLPDDIKRLPAQAIRCDLINCDIANMHCFVNTYIKIRVH 452
                |...:.|.:|..||  ..:|:|:|.|....||.||..|.|     |.:..|
Zfish   542 QLSEDKVKVYFLDHGFFDLVSRKTVFQLRDQFMTLPFQATTCQL-----AGLEPF---------- 591

  Fly   453 ENNNSTLVAEPVIDRLSRPTKTNTTKYPAGITEDDMAMLNEIDESTSDPLKAVLGFRPKDEQRIC 517
                ||   :||:.:..:.....            .::|.||.|....||..:......|:..:.
Zfish   592 ----ST---DPVVLKTLQSLAVG------------RSLLAEIVEREDTPLVVLYDTSENDDVNVT 637

  Fly   518 RHYDPKLNGCFKGNNCRFAHEPFAPNGATKDVELARALPETIFDTTVHFEIGSIVGILITFINGP 582
            ..       |.|....:....|...|....:|    .:.....|.:|:.::.|.....:..|...
Zfish   638 AM-------CLKALQDKSMENPLQVNSVYTNV----CVTNVCSDGSVYCQLPSRGQAKLKDIMDK 691

  Fly   583 TEVYGQFLDGSPPLVWDKKDVPENKRTFKSKPRLLDIVLALYSDGCFYRAQIIDEFPSEYM-IFY 646
            .|.:  |:.   .|.|:         ...|:|....:.||.|. |.:.||:||:...|..: |.:
Zfish   692 IEAH--FIS---QLTWE---------LLVSRPFCGKVCLAKYK-GKWARAEIINLHGSHVLDILF 741

  Fly   647 VDYG---------NTEFVP-------------LSCLAPCENVDS--FKPHRVFSFHIEGIVRSKN 687
            :|.|         ..|..|             :.||....|||.  :.|        |.::..:.
Zfish   742 LDLGLPASLEVSELREIPPIFLKELITIPPQAIKCLLEDLNVDRAVWPP--------EAVLWLRE 798

  Fly   688 LTHQKTIECIEYLKSKLLNTEMNVHL 713
            ..|.|...|::.:|   |:....||:
Zfish   799 TVHNKAPSCMKIVK---LDETRTVHI 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	28/135 (21%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	16/66 (24%)
tdrd7a	NP_001092813.1	LOTUS_1_TDRD7	4..91	CDD:193600	18/87 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..175		6/24 (25%)
		LOTUS_2_TDRD7	206..271	CDD:193587	10/65 (15%)
		LOTUS_3_TDRD7	367..434	CDD:193588	12/73 (16%)
		TUDOR	465..587	CDD:278965	25/132 (19%)
		TUDOR	520..573	CDD:197660	9/52 (17%)
		TUDOR	659..778	CDD:278965	26/137 (19%)
		TUDOR	712..757	CDD:119391	12/45 (27%)
		TUDOR	891..1007	CDD:278965
		TUDOR	945..988	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000