DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment krimp and Tudor-SN

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001261195.1	Gene:	Tudor-SN / 38045	FlyBaseID:	FBgn0035121	Length:	926	Species:	Drosophila melanogaster

Alignment Length:	775	Identity:	137/775 - (17%)
Similarity:	224/775 - (28%)	Gaps:	317/775 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 VVETEKANNPVRSEASAPATSDNQSLLAAKQGTQTIGTGICNKISKSTINMPN-NWQLENPTEV- 269
            |||:......|........|::.|:|:..:...:..|.|..:..:.:...:.| .|..|||..:
  Fly   125 VVESIVREGLVSVRREGRPTAEQQTLIELEDQARAAGRGKWSPTASAADKVRNIKWSHENPAHLV 189

  Fly   270 -------TAASIEKVN----------------------------------------KLPKSPRNR 287
                   ..|.||.|.                                        |:|.:...|
  Fly   190 DIYGGNPVKAIIEHVRDGSTVRAFLLPDFHYITLMISGIRCPGVKLDADGKPDLSVKVPFADEAR 254

  Fly   288 FLLPPKGGTETTRRD-------IYNQILKDMAAFPENTIVTAVLASVDVTDNCAYVAKWD----- 340
            :.:.    |...:||       :.|........:|:..|..::|     .:..|....|.
  Fly   255 YYVE----TRLLQRDVEIRLESVNNSNFIGTILYPKGNIAESLL-----REGLAKCVDWSMAVMK 310

  Fly   341 ESSDRIKKVLQRQLPLQELDQLPDY---------------GDIFAVL--DSI-----NNIITRIT 383
            ..:|:: :..:|....:.|.|..||               |.:..|.  |:|     |..:.::.
  Fly   311 TGTDKL-RAAERFAKEKRLRQWQDYQAKTPAFNSKEKDFSGTVVEVFNGDAINVRLSNGQVKKVF 374

  Fly   384 INSSSAGGGYDAYLIDFGEHI-----------------H-FDGNETIFKLPDDIKRLPAQAIRC- 429
            .:|........|.:...||.|                 | ||..|.:      .|:|..:.::|
  Fly   375 FSSIRPPRDQRAVVGTDGEEIVKAPPRGKNYRPLYEIPHMFDAREFL------RKKLINKKVQCN 433

  Fly   430 -DLINCDIANM---HCF-----------------VNTYIKIRVHENNNST----LVA--EPVIDR 467
             |.|:....|.   :|:                 :.|.::.|..::..|:    |:|  :..|..
  Fly   434 LDYISPPRENFPEKYCYTVSIGGQNVAEAMVAKGLATCVRYRQDDDQRSSAYDQLIAAEQQAIKG 498

  Fly   468 LS--RPTKTNTTKYPAGITEDDMAMLNEIDESTSDPLK--AVLG----------FRPKDEQRI-- 516
            |.  ...|.|.|.....:|.|...:..:...|....|:  |::.          |.|||...:
  Fly   499 LKGLHAKKDNATLRVNDLTVDHSRIKVQYLPSWQRALRTEAIVEFVASGSRLRIFVPKDSCLVTF 563

  Fly   517 ------C-RHYDPKLNG--CFKGNNCRFAHEPFAPNGATKDVELARALPETIFDTTVHFEI---- 568
                  | |...|.|||  ..:|       |||.....|...|  |.|..   |.:||.:.
  Fly   564 LLAGISCPRSSRPALNGVPAQEG-------EPFGDEALTFTRE--RVLQR---DVSVHIDTTDKA 616

  Fly   569 -GSIVGILIT-------------------FINGPTEVYGQF------LDGSPPLVWDK--KDVPE 605
             .|::|.|.|                   |....:|.|.|.      ...:...:|..  ::||:
  Fly   617 GSSVIGWLWTDSGANLSVALVEEGLAEVHFSAEKSEYYRQLKIAEDRAKAAKKNIWTNYVEEVPK 681

  Fly   606 NKRT----------------------------------------------------FKSKPRLL- 617
            .|..                                                    |:|.|.:.
  Fly   682 EKTVTEEEKEDKVVAERKVNYENVIVTEITETLTFFAQSVESGSKLESLMSKLHADFQSNPPIAG 746

  Fly   618 -------DIVLALYS-DGCFYRAQIIDEFPSEYMIFYVDYGNTEFVPLSCLA------------- 661
                   |:|.|.:: |..:|||::.....|...:.|:||||.|.:|.:.||
  Fly   747 SYTPKRGDLVAAQFTLDNQWYRAKVERVQGSNATVLYIDYGNKETLPTNRLAALPPAFSSEKPYA 811

  Fly   662 ----------PCENVDSFKPHRVFSFHIEGIVRSKNLTHQKTIECIEYLKSKLLNTEMNV 711
                      |.:|.|..:..|.||..:        |.|:..           ||.|:.|
  Fly   812 TEYALALVALPTDNEDKEEALRAFSEDV--------LNHKVQ-----------LNVELKV 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	38/226 (17%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	17/67 (25%)
Tudor-SN	NP_001261195.1	SNc	23..166	CDD:214615	9/40 (23%)
		SNc	195..333	CDD:214615	20/147 (14%)
		SNc	346..504	CDD:320778	28/163 (17%)
		SNc	538..672	CDD:214615	30/145 (21%)
		TUDOR	697..817	CDD:306940	20/119 (17%)
		SNc	767..914	CDD:320778	25/105 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900