DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and Tdrd6

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001178512.1	Gene:	Tdrd6 / 316254	RGDID:	1305956	Length:	2136	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	134/644 - (20%)
Similarity:	220/644 - (34%)	Gaps:	199/644 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 VVAVQEASSTNQLDAISVVNENLSEERDATPQPLAVSKNMEETMPSNPFHEQLEGSLEEIPVGSK 205
            |:.:.:.|.|.: :.||.|   :::...|..|.....:|:..:..| |.|           |...
  Rat   648 VIEILDESRTGE-ENISKV---IAQAGYAKFQEFETKENIRLSAHS-PGH-----------VSGH 696

  Fly   206 IVVETEKANNPVRSEASAPATSDNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQLENPTEVT 270
            .:.|:.|..:..:.|....|.:||::|    ...:.:.|     :|.|.|:          |..|
  Rat   697 FIAESSKIPSVKKVEGDQKAKNDNKTL----SDPEALAT-----VSLSNIS----------TGQT 742

  Fly   271 AASIEKVNKLPKSPRNRFLLPPK-----------GGT-ETTRRDIYN------QILKDMAAFPEN 317
            |...|||...|...... ||..|           |.| |.....|.|      |::::...|  .
  Rat   743 AQDKEKVTSDPTLLMLN-LLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGF--R 804

  Fly   318 TIVTAVLASVDVTDNCAYVAKWDESSDRIKKVLQRQLPLQELDQLPDYGDIFAVLDSINNIITRI 382
            |::      .|:.|.|                        :.:..|..||            ||.
  Rat   805 TLM------CDIEDYC------------------------KSEPSPYEGD------------TRA 827

  Fly   383 TINSSSAGGGYDAYLIDFG---EHIHF----DGNETIFKLPDDIK------RLPAQAIRCDLINC 434
            .:...:|.|.:...||...   ||:..    .|::.:..:.|.:.      ::.|||.||.|.|
  Rat   828 CLAKRTANGRWSRALISGAQSLEHVRVVFVDYGDKDVVSMKDILSVSDVFFKVRAQAFRCSLYN- 891

  Fly   435 DIANMHCFVNTYIKIRVHENNNSTLVAEPVIDRLSRPTKTNTTKYPAGITEDDMAMLNEIDESTS 499
                                             |.:||..|...:.....:   |....||.:..
  Rat   892 ---------------------------------LIQPTGENPFVWDERAIQ---AFTGFIDNAWQ 920

  Fly   500 DPLKA-----VLGFRPKDEQRICRHYDPKLNGCFK--------GNNCRFAHEPFAPNGATKDVEL 551
            :.|:.     .|..|.::|             ||.        .:.|.|..|    ....:.|:|
  Rat   921 NNLELKCTIFALASRHEEE-------------CFNVVDLLTPFQSACHFLVE----KRLARPVKL 968

  Fly   552 ARALPETI-----FDTTVHFEIGSIVGILITFINGPTEVYGQFLDGSPPL------VWDKKDVPE 605
            .:.|..::     :.:|...:|||...:.||..:.|...|.|....:..|      :.....|..
  Rat   969 QKPLEPSVQLHSYYYSTHDLKIGSEELVYITHADDPWTFYCQLARNTNILEQLSYHIMQLSKVLL 1033

  Fly   606 NKRTFKSKPRLLDIVLALYSDGCFYRAQIIDEFPSEYMIFYVDYGNTEFVPLSCLAPCENVDSFK 670
            |.||....|..|  .||.|:||.:||..||::.||:  :|:||:||| :|....|.|... |::.
  Rat  1034 NLRTSTLVPGTL--CLAKYTDGNWYRGIIIEKEPSK--VFFVDFGNT-YVASDHLLPIPR-DAYD 1092

  Fly   671 PHRVFSFHIEGIVRS-KNLTHQKTIECIEYLKSKLLNTEMNVHLVQRLPDGFLIRFLDD 728
               |....::.:..| .::.|....|...:.:..:|:..:...:|.:.|||.||..|.|
  Rat  1093 ---VLLLPMQAVKCSLSDIPHHIPEEVTAWFQETVLDKSLKALVVAKDPDGRLIIELYD 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	37/116 (32%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	19/43 (44%)
Tdrd6	NP_001178512.1	TUDOR	10..133	CDD:278965
		TUDOR	245..379	CDD:278965
		TUDOR	313..359	CDD:119391
		TUDOR	489..610	CDD:278965
		TUDOR	547..591	CDD:119391
		TUDOR	775..891	CDD:278965	30/159 (19%)
		TUDOR	827..870	CDD:119391	7/42 (17%)
		TUDOR	988..1107	CDD:278965	38/127 (30%)
		TUDOR	1043..1085	CDD:119391	20/46 (43%)
		TUDOR	1310..1429	CDD:278965
		TUDOR	1363..1407	CDD:119391
		TUDOR	1523..1645	CDD:278965
		TUDOR	1578..>1616	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000