DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and Rnf17

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	XP_038949233.1	Gene:	Rnf17 / 305908	RGDID:	1310486	Length:	1650	Species:	Rattus norvegicus

Alignment Length:	910	Identity:	179/910 - (19%)
Similarity:	306/910 - (33%)	Gaps:	310/910 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLEDISMIMKLFDSNMHKLQ---GNLRSYQTEMHQIHKELTEKLSHADLLYRSLIPLHDHLVASL 63
            |.|.:|..:|:.||...:.:   |:||           |:.||             ..|.|:|||
  Rat   156 NSEQLSNAIKMLDSTQDQTRQETGSLR-----------EVVEK-------------QFDTLIASL 196

  Fly    64 SEVNAHVMKLNVQLHINRQSVRLGDYEYYEKSIDNPYSSIRSGLQAIEKPGCAEAICQSSKPAFV 128
            ......:.:         :.||..| :|..|.:     :::|.::  ||....:|..:.:|.  :
  Rat   197 DSRKKSLCE---------ELVRRTD-DYLSKLV-----TVKSYIE--EKKSDLDAAMKIAKE--L 242

  Fly   129 ECLPS--STSEEVPVVAVQEASSTNQLDAISVV--------NENLSEE------------RDAT- 170
            :..||  :..:...::...:.:..::|..:|.:        |.|.||.            .|:|
  Rat   243 KSAPSLRTYCDLTQIIRTLKLNFESELSQVSSIIPRNPPRLNINCSEVICMFNSMGKIEFEDSTK 307

  Fly   171 --PQPLAVSKNMEETMPSNPFHEQLE------GSLEEIPVGSKIVVETEKANNPVRSEASAPATS 227
              ||...|.:|:::     .|:.:.|      .|||:..|.: :|:..|....|:::|     |.
  Rat   308 CHPQENEVGQNVQK-----KFNSKKELCCDVYSSLEKKRVDT-VVLADEAPVPPLQAE-----TP 361

  Fly   228 DNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQLENPTEVTAASIEKVN-------------K 279
            |.......||..:.:   :.....|:...:|   ||.:..:|....|.:.|             :
  Rat   362 DRHLEGENKQPQKEV---LVVASPKTVAVLP---QLGSSPDVIIEEIIEENLESCFTDEPIETPR 420

  Fly   280 LPKSPRNRFLLPPKGGTETTRRDIYNQILKDMAAFPENTIVTAVLASVDVTDNC-AYVAKWDESS 343
            .||.|..:.|..|               :...|..||...|:      .||..| .||.|:.:..
  Rat   421 YPKKPPQKELSAP---------------VASKAGCPELVFVS------HVTHPCHFYVRKYSQIK 464

  Fly   344 D------RIKKVLQRQLPLQELDQLPDYGDIFAVLDSINN------IITRI------TINSSSAG 390
            |      ::|:|..:.|.|...|.|.....||  ::||.|      |||.|      .:....:.
  Rat   465 DAAMLEKKMKQVCSKSLHLDPSDTLELGARIF--VNSIKNRMWCRGIITEIIPTKTKNVRKPCSP 527

  Fly   391 GGYDA--------YLIDFG-----------------EHIHFDGNETIFKLPDD------------ 418
            ..:..        :::|||                 ||:    .|....|.|.
  Rat   528 TKFSVCEISLIQIFMVDFGNSEVLIITGVGDTHVGPEHV----GEQHITLSDFCLLVRKSEPYSE 588

  Fly   419 --IKRLPAQAIRCDLINCDIANMHCFVNTYIKIRVHENNNSTLVAEPVIDRLSRPTKTNTTKYPA 481
              :|.:|..|..|.|                |..|..|::.....|..::.|....|........
  Rat   589 ELLKDIPHLAHLCSL----------------KDIVPYNSSEGWEKEAKVEFLKMVNKKAVLMKVF 637

  Fly   482 GITEDDMAML-------NEIDESTSDPLKAVLGFRPKDEQRICRHYDPKLNGCFKGNNCRFAHEP 539
            | .|||:.::       |:|.......|:..|.|     ..:.|.....|.. ...||....:.|
  Rat   638 G-EEDDILIVDLQKPPTNKISSDMPVSLRDALVF-----MELARFRSQSLRS-HGENNTALCYRP 695

  Fly   540 FAPNGATKDVELARALPETIFDTTVHFEIGSIVGILITFINGPTEVYGQFLDGSPPL-------V 597
                         .||||.:.:          |.:::..||.||:.|.|.::....|       .
  Rat   696 -------------PALPEEMTE----------VSVMVCHINSPTDFYLQLMENLDFLSLLKTIEE 737

  Fly   598 WDKKDVPENKRTFKSKPRLLDIV--------LALYSDGCFYRAQIIDEFPS--EYMIFYVDYGNT 652
            :.|.:..||          |:|:        :|.:.||.:|||::|. .|.  |..:.|||:|||
  Rat   738 FYKGEDGEN----------LEILCPLQNQACVAKFEDGIWYRAKVIG-LPGHREVEVKYVDFGNT 791

  Fly   653 EFVPLSCLAPCENVDSFKPHRVFSFHIEGIVRSK-------------NLTHQKTIEC--IEYLKS 702
            ..:.|..:...::.....|.:.....:..|..||             ..|..|.:.|  |:.|::
  Rat   792 AKITLKDMRKIKDEFLEPPEKAIKCKLAFIEPSKRSHWSKKAKEKFEEKTQDKFVTCSVIKILEN 856

  Fly   703 KLLNTEM-------------NVHLVQR----LPDGFLI-----RFLDDWKYIPEQLLQRNYAQVS 745
            .:|..|:             |..||:.    ...|:.:     :.|:.|...||:::......:|
  Rat   857 GVLLVELFDSRAPGTSAVSINEQLVKEGLASYEAGYTLKDNSKKHLEVWDPSPEEIISSEINSLS 921

Fly 746 745
Rat 922 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	30/127 (24%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	17/53 (32%)
Rnf17	XP_038949233.1	PHD_SF	30..72	CDD:419867
		BBC	137..>242	CDD:128778	27/128 (21%)
		Tudor_TDRD4_rpt1	490..566	CDD:410485	13/77 (17%)
		Tudor_TDRD4_rpt2	728..823	CDD:410486	24/105 (23%)
		Tudor_TDRD4_rpt3	968..1049	CDD:410487
		Tudor_TDRD4_rpt4	1247..1314	CDD:410488
		Tudor_TDRD4_rpt5	1504..1608	CDD:410489
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900