DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and Rnf17

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001028215.1	Gene:	Rnf17 / 30054	MGIID:	1353419	Length:	1640	Species:	Mus musculus

Alignment Length:	888	Identity:	175/888 - (19%)
Similarity:	293/888 - (32%)	Gaps:	282/888 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NLEDISMIMKLFDSNMHKLQGNLRSYQTEMHQIHKELTEKLSHAD----LLYRSLIPLHDHLVAS 62
            |.|.:|..:|:.||...:.:....|. ||  .:.|:....|:..|    .|...||...|..::.
Mouse   156 NFEQLSNAIKMLDSTQDQTRQETHSL-TE--AVEKQFDTLLASLDSRKKSLCEELIRRTDDYLSK 217

  Fly    63 LSEVNAHV----------MKLNVQLHINRQSVR-LGDYEYYEKSIDNPYSSIRSGLQAI---EKP 113
            |..|.:::          ||:..:|. :..|:| ..|.....:::...:.|..|.:.:|   ..|
Mouse   218 LVTVKSYIEEKKSDLDAAMKIAKELR-SAPSLRTYCDLTQIIRTLKLTFESELSQVSSIIPRNTP 281

  Fly   114 ----GCAEAICQSSKPAFVE------CLPSSTSEEVPVVAVQEASSTNQLDAISVVNENLSEER- 167
                .|:||||..|....:|      |.|....:...|    :....|:.:....|..:|.:::
Mouse   282 RLDINCSEAICMFSSMGKIEFEDSTKCYPQENEDGQNV----QKKFNNRKELCCDVYSSLEKKKV 342

  Fly   168 ------DATPQPLAVSKNMEETMPSNPFHEQLEGSLEEIPVGSKIVVETEKANNPVRSEASAPAT 226
                  |.||:|     .::...|.    ..|||..:: |....:||.:.|....:....|:|..
Mouse   343 DAAVLTDETPEP-----PLQAEAPD----RHLEGKKKQ-PTKEMVVVTSPKTIAVLPQLGSSPDV 397

  Fly   227 SDNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQLENPTEVTAASIEKVNKLPKSPRNRFLLP 291
                               |..:|.:..:   .:...::|.|.:.        .||.|..:....
Mouse   398 -------------------IIEEIIEENL---ESCFTDDPIETSG--------YPKKPPQKEQSA 432

  Fly   292 PKGGTETTRRDIYNQILKDMAAFPENTIVTAVLASVDVTDNCAYVAKWDESSD------RIKKVL 350
            |.|               ..|..||...|:.|:.....     ||.|:.:..|      ::|:|.
Mouse   433 PVG---------------SKAGCPELVFVSHVIHPCHF-----YVRKYSQIKDATILEKKMKQVC 477

  Fly   351 QRQLPLQELDQLPDYGDIFAVLDSINN------IITRI------TINSSSAGGGYDA-------- 395
            .|.|.|...|.|.....||  ::||.|      |||.|      .|....:...:..
Mouse   478 NRSLHLDPSDILELGARIF--VNSIKNRMWCRGIITEIIPSKTKNIRKPCSPTKFSVCEISLIQI 540

  Fly   396 YLIDFG-----------------EHIHFDGNETI----FKL---------PDDIKRLPAQAIRCD 430
            :::|||                 ||   ||.:.|    |.|         .:.:|.:|..|..|.
Mouse   541 FMVDFGNSEVLIITGVGDTHEGPEH---DGEQHITLSDFCLLLMKSEPYSEELLKDIPHLAHLCS 602

  Fly   431 LINCDIANMHCFVNTYIKIRVHENNNSTLVAEPVIDRLSRPTKTNTTKYPAGITEDDMAML---- 491
            |                |..|..|:......|..::.|....|........| .|||:.::
Mouse   603 L----------------KDIVPYNSTEGWEKEAKVEFLKMVNKKAVLMKVFG-EEDDVLIVDLQK 650

  Fly   492 ---NEIDESTSDPLKAVLGFRPKDEQRICRHYDPKLNGCFKGNNCRFAHEPFAPNGATKDVELAR 553
               |:|.......|:..|.|.   |....|...|:.:.  :.|.....|.|..|...|:
Mouse   651 PPTNKISSDMPVSLRDALVFM---ELARFRSQSPRSHS--EKNTTLCYHPPILPEEMTE------ 704

  Fly   554 ALPETIFDTTVHFEIGSIVGILITFINGPTEVYGQFLDGSPPL-------VWDKKDVPENKRTFK 611
                              |.:::..||.||:.|.|.::....|       .:.|.:..||
Mouse   705 ------------------VSVMVCHINSPTDFYLQLMENLDFLSLLKTIEEFYKGEDGEN----- 746

  Fly   612 SKPRLLDIV--------LALYSDGCFYRAQIIDEFPS--EYMIFYVDYGNTEFVPLSCLAPCENV 666
                 |:|:        :|.:.||.:|||::|. .|.  |..:.|||:|||..:.|..:...::.
Mouse   747 -----LEILCPLQNQACVAKFEDGIWYRAKVIG-LPGHREVEVKYVDFGNTAKITLKDMRKIKDE 805

  Fly   667 DSFKPHRVFSFHIEGIVRSK-------------NLTHQKTIEC--IEYLKSKLLNTEM------- 709
            ....|.:.....:..:..||             ..|..|.:.|  |:.|::.:|..|:
Mouse   806 FLEPPEKAIKCKLAYVEPSKKSQWSKKAKEKFEEKTQDKFVTCSVIKILENNVLLVELFDSRAPG 870

  Fly   710 ------NVHLVQR----LPDGFLI-----RFLDDWKYIPEQLL 737
                  |..||:.    ...|:.:     :.|:.|...||:::
Mouse   871 KSAVSINDQLVKEGLASYEAGYTLKDNSKKHLEVWDPSPEEII 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	30/127 (24%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	17/53 (32%)
Rnf17	NP_001028215.1	iSH2_PI3K_IA_R	158..>242	CDD:304922	19/86 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..376		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..435		6/29 (21%)
		TUDOR	444..>551	CDD:278965	26/113 (23%)
		TUDOR	698..819	CDD:278965	32/155 (21%)
		TUDOR	755..801	CDD:119391	16/46 (35%)
		TUDOR	937..1053	CDD:278965
		TUDOR	990..1036	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1170..1191
		TUDOR	1196..1312	CDD:278965
		TUDOR	1250..1295	CDD:119391
		TUDOR	1426..1567	CDD:278965
		TUDOR	1501..1548	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900