DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and TDRD6

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001010870.1	Gene:	TDRD6 / 221400	HGNCID:	21339	Length:	2096	Species:	Homo sapiens

Alignment Length:	955	Identity:	164/955 - (17%)
Similarity:	318/955 - (33%)	Gaps:	331/955 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VMKLNVQLHI-NRQSVRLGDYEYYEKSIDNPYSSIRSGLQAIEKPGCAE---------AICQSSK 124
            |:...:.:|| ::|     |::|..:.:|...:...:..:.|.:.|.|:         .:..:..
Human   624 VLHKELVIHILDKQ-----DHQYVIEILDESRTGEENISKVIAQAGYAKYQEFETKENILVNAHS 683

  Fly   125 PAFVECLPSSTSEEVPVVAV----QEASSTNQLDAIS----------------VVNENLSEERDA 169
            |..|....::.|.::|....    |:|...|:..::|                ||.|.:  :|.:
Human   684 PGHVSNHFTTESNKIPFAKTGEGEQKAKRENKTTSVSKALSDTTVVTNGSTELVVQEKV--KRAS 746

  Fly   170 TPQPLAVSKNMEETMPSNPFHEQLEGSLEEIPVGSKIVVETEKANNP-------VRS-EASAPAT 226
            ...||  .:|..|..|.:       .|..|:.|||.:.|......||       .|: :......
Human   747 VYFPL--MQNCLEIKPGS-------SSKGELEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLM 802

  Fly   227 SDNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQ------LENPTEVTAASIEKVNKLPKSPR 285
            ||.|.............|..|  ::|.|:|  ..|.      :::...|....::..::...|.:
Human   803 SDIQYYCKNTAAPHQRNTLAC--LAKRTVN--RQWSRALISGIQSVEHVNVTFVDYGDREMVSVK 863

  Fly   286 NRFLLPP---KGGTETTRRDIYNQILKDMAAFPENTIVTAVLASVDVTDNCAYVAKWDESSD--- 344
            |.:.:..   |...:..|..:|| :::.:...|....|.|:.|..:..||.     |.::.:
Human   864 NIYSISEEFLKVKAQAFRCSLYN-LIQPVGQNPFVWDVKAIQAFNEFIDNA-----WQKNLELKC 922

  Fly   345 --------------------------------RIKKVLQRQLPLQELDQLPDY------------ 365
                                            |:.:.::.|.||:...||..|
Human   923 TIFALASINEELFNIVDLLTPFQSACHFLVEKRLARPVKLQKPLESSVQLHSYFYSTHDMKIGSE 987

  Fly   366 ---------------------GDIFAVLDSINNIITRITINSSSA--------------GGGY-- 393
                                 .:|...|......::::.:|..::              |..|
Human   988 ELVYITHIDDPWTFYCQLARNANILEQLSCSITQLSKVLLNLKTSPLNPGTLCLAKYTDGNWYRG 1052

  Fly   394 --------DAYLIDFGEHIHFDGNETIFKLPD---DIKRLPAQAIRCDLINCDIANMHC------ 441
                    ..:.:||| :|:...::.:..:|.   |:..||.||:||.|  .||.: |.
Human  1053 IVIEKEPKKVFFVDFG-NIYVVTSDDLLPIPSDAYDVLLLPMQAVRCSL--SDIPD-HIPEEVVV 1113

  Fly   442 -FVNTYI-----KIRVHENNNSTLVAEPVIDRL----SRPTKTNTTKYPAGITEDDMAM------ 490
             |..|.:     .:.|.::.:.||:.|...|.:    |...|.....|...|.:.:..:
Human  1114 WFQETILDKSLKALVVAKDPDGTLIIELYGDNIQISASINKKLGLLSYKDRIRKKESEVLCSTTE 1178

  Fly   491 -LNEIDESTSDP----LKAVLGFRPKDEQRICRHYDPKLNGCFK--------------------- 529
             |.|.:|:...|    |...:|::..:::.:...|.|::|..:|
Human  1179 TLEEKNENMKLPCTEYLSKSVGYKLPNKEILEESYKPQINSSYKELKLLQSLTKTNLVTQYQDSV 1243

  Fly   530 GNNCRFAHEPFAPNGATKDVELARALP--------------------------------ETI--- 559
            ||.    :....|....|..|::...|                                :||
Human  1244 GNK----NSQVFPLTTEKKEEISAETPLKTARVEATLSERKIGDSCDKDLPLKFCEFPQKTIMPG 1304

  Fly   560 FDTTVHFEIGSIVGILITFINGPTEVYGQFLDGSPPLVWDKKDVPENKRTFKSKPRLL------- 617
            |.|||:          ::.||..::.|.|.::....:    ..:.|...:.|::|...
Human  1305 FKTTVY----------VSHINDLSDFYVQLIEDEAEI----SHLSERLNSVKTRPEYYVGPPLQR 1355

  Fly   618 -DIVLALY-SDGCFYRAQIIDEFPSEYM-IFYVDYGNTEFVPLSCLAPCENVDSFKPHRVFSFHI 679
             |::.|:: .|..:|||.|.::.|::.: :.::||||...|..:.:...:.|::..|.......:
Human  1356 GDMICAVFPEDNLWYRAVIKEQQPNDLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSL 1420

  Fly   680 EGI-----VRSKNLTH---QKT----IECIEYLK--------------------------SKLLN 706
            :|.     ..||.:.|   |:|    |.| |::|                          |:...
Human  1421 QGFEVPDNKNSKKMMHYFSQRTSEAAIRC-EFVKFQDRWEVILADEHGIIADDMISRYALSEKSQ 1484

  Fly   707 TEMNVHLVQRLPDGFLIR-------FLDDWKYIPEQLLQRNYAQV 744
            .|::..:::......:.:       || :| |.||:.:.|.||.|
Human  1485 VELSTQVIKSASSKSVNKSDIDTSVFL-NW-YNPEKKMIRAYATV 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	22/120 (18%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	13/45 (29%)
TDRD6	NP_001010870.1	TUDOR	<69..133	CDD:278965
		TUDOR	246..380	CDD:278965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..316
		TUDOR	314..360	CDD:119391
		TUDOR	483..604	CDD:278965
		TUDOR	541..585	CDD:119391
		TUDOR	770..886	CDD:278965	21/119 (18%)
		TUDOR	821..866	CDD:119391	8/48 (17%)
		TUDOR	982..1102	CDD:278965	18/122 (15%)
		TUDOR	1037..1080	CDD:119391	6/43 (14%)
		TUDOR	1301..1422	CDD:278965	27/134 (20%)
		TUDOR	1356..1401	CDD:119391	13/44 (30%)
		TUDOR	1516..1638	CDD:278965	6/12 (50%)
		TUDOR	1571..>1609	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910