DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and Tdrd6

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001154838.1	Gene:	Tdrd6 / 210510	MGIID:	2679727	Length:	2135	Species:	Mus musculus

Alignment Length:	638	Identity:	125/638 - (19%)
Similarity:	210/638 - (32%)	Gaps:	203/638 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LDAISVVNENLS----EERDATPQPLAVSKNMEETMPSNPFHEQLEGSLEEIPVGSKIVVETEKA 213
            ||...:..||:|    :...|..|.....:|:..:..| |.|           |....:.|..|.
Mouse   652 LDESRMGEENISKVIAQAGFAKFQEFETKENIRLSAHS-PGH-----------VSGHFMAEPSKI 704

  Fly   214 NNPVRSEASAPATSDNQSLLAAKQGTQTIGTGICNKISKSTINMPNNWQLENPTEVTAASIEKVN 278
            .:..::|....|..||::|        ::...:.:.:|.|.::             ||...|||.
Mouse   705 TSAKKAEGDQRAKKDNKTL--------SVSEALADTVSLSNLS-------------TAQDTEKVT 748

  Fly   279 KLPKSPRNRFLLPP-----KGGTET------------TRRDIYNQILKDMAAFPENTIVTAVLAS 326
            ..|......||...     ||..|.            .....:.|::::...|  .|::
Mouse   749 SDPSLLMLNFLKTKPDCCGKGELEVGSTVEVKVSHIENPGSFWCQLMRNAQGF--RTLM------ 805

  Fly   327 VDVTDNCAYVAKWDESSDRIKKVLQRQLPLQELDQLPDYGDIFAVLDSINNIITRITINSSSAGG 391
            .|:.|.|    |..|.|                   |..||            ||:.:...:|.|
Mouse   806 CDIEDYC----KSSEPS-------------------PYEGD------------TRVCLAKRTASG 835

  Fly   392 GYDAYLI--------------DFGEHIHFDGNETIFKLPDDIKRLPAQAIRCDLINCDIANMHCF 442
            .:...||              |:|:. .....:.|..:.|...::.|||.||.|.|
Mouse   836 RWSRALISGAHSLEHVRVVFVDYGDR-DVVSTKDILSVSDVFFQVRAQAFRCSLYN--------- 890

  Fly   443 VNTYIKIRVHENNNSTLVAEPVIDRLSRPTKTNTTKYPAGITEDDMAMLNEIDESTSDPLKA--- 504
                                     |.:|...|...:.....:   |....||.:..:.|:.
Mouse   891 -------------------------LIQPMGENPFVWDEKAVQ---AFSGFIDSARQNNLELKCT 927

  Fly   505 --VLGFRPKDE-----------QRICRHYDPKLNGCFKGNNCRFA-----HEPFAPNGATKDVEL 551
              .|..|.::|           |..||....|          |.|     .:|..|:     |:|
Mouse   928 VFALASRHEEEWFNVVDLLTPFQSACRFLVEK----------RLARPVKHQKPLEPS-----VQL 977

  Fly   552 ARALPETIFDTTVHFEIGSIVGILITFINGPTEVYGQFLDGSPPLVWDKKDVPE-NKRTFKSKPR 615
                 .:.:.:|...:|||...:.:|..:.|...|.|....:..|.....::.: :|.....|..
Mouse   978 -----HSYYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKAS 1037

  Fly   616 LL---DIVLALYSDGCFYRAQIIDEFPSEYMIFYVDYGNTEFVPLSCLAPCENVDSFKPHRVFSF 677
            .|   .:.||.|:||.:||..||::.||:  :|:||:||| ::.:..|.|...    ..|.|...
Mouse  1038 TLAPGTLCLARYTDGNWYRGIIIEKEPSK--VFFVDFGNT-YIAVDHLLPIPR----DAHDVLLL 1095

  Fly   678 HIEGIVRS-KNLTHQKTIECIEYLKSKLLNTEMNVHLVQRLPDG-FLIRFLDD 728
            .::.:..| .::.|....|...:.:..:|:..:...:|.:.||| .:|...||
Mouse  1096 PMQALKCSLSDIPHHIPEEVTAWFQETVLDKSLKALVVAKDPDGRLIIELYDD 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	32/114 (28%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	18/43 (42%)
Tdrd6	NP_001154838.1	TUDOR	10..133	CDD:278965
		TUDOR	245..379	CDD:278965
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..315
		TUDOR	313..359	CDD:119391
		TUDOR	489..610	CDD:278965
		TUDOR	547..591	CDD:119391
		TUDOR	773..890	CDD:278965	28/160 (18%)
		TUDOR	826..869	CDD:119391	6/43 (14%)
		TUDOR	987..1106	CDD:278965	33/125 (26%)
		TUDOR	1042..1084	CDD:119391	18/44 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1296
		TUDOR	1309..1428	CDD:278965
		TUDOR	1362..1406	CDD:119391
		TUDOR	1519..1641	CDD:278965
		TUDOR	1574..1621	CDD:119391
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1699..1733
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1860..1885
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1930..1987
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000