DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and TDRD15

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001293066.1	Gene:	TDRD15 / 100129278	HGNCID:	45037	Length:	1934	Species:	Homo sapiens

Alignment Length:	957	Identity:	172/957 - (17%)
Similarity:	305/957 - (31%)	Gaps:	322/957 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LSH----ADLLYRSLIPLHDHLVASLSEVNAHVMKLNVQLHINRQSVRLGDYEYYEKSIDNPYSS 102
            |:|    .||..::.|.....||.:.:.:...:.|.:.:..:|.|||...:      :||    .
Human   598 LAHIFPVEDLWTKAAIDYFKKLVLNKAILLQVIAKKDDKYTVNIQSVEASE------NID----V 652

  Fly   103 IRSGLQAIEKPGCAEAICQSSKPAFVECLPSSTSEEVPVVAVQEASSTNQLDAISVV-------- 159
            |...|||    |.||..     ...:|..|.|.||    .::..:.|.|:::...|:
Human   653 ISLMLQA----GYAEYF-----QVELEYFPKSVSE----YSMLNSESKNKVNIKKVISALLEGPK 704

  Fly   160 -----NENLSEERDATPQPLAVSKNMEE-----TMPSNP-------------------------- 188
                 :.||.|...:.|:.|||  |:.|     |:...|
Human   705 SKKYHSNNLVENNLSLPKSLAV--NISEFKNPFTLSVGPESSWPYKEYIFRPGTVLEVKCSCYYG 767

  Fly   189 ---FHEQLEGSLEEIPVGSKIVVETEKANNPVRSEASAPATSDNQSLLAAKQGTQTIGTGICNKI 250
               |..||:...|::    |:::|..:....:.|:    .....|:...||...:.....:..::
Human   768 PGDFSCQLQCKSEDL----KLLMEQIQNYYSIHSD----PYEIGQTACVAKYSGKWCRAAVLTQV 824

  Fly   251 SKST--INMPNNWQ----LENPTEVTAASIEKVNKLPKSPRNRFLLPPK----GGTETTRRDIYN 305
            ||..  :.:...:|    :|:...:....:...::..:...|.|:.|..    ..|....||::|
Human   825 SKEVDIVFVDYGYQKRVLIEDLCAINPRFLLLESQAFRCCLNHFIEPVSCKLFSWTRKAFRDLWN 889

  Fly   306 QILKDMAAFPENTIVTAVL-ASVDVTDNCAY-VAKWDESSDRIKKVLQRQLPLQELDQLPDYGDI 368
            .|.....      ::|.:: |.|.:..|..| :.....|....|:.|..:...|.:.....:..:
Human   890 FISSSRG------LLTCIIYALVIIHPNHLYNLVDLQSSFTSAKEFLMNRGSAQYITLSETFPSL 948

  Fly   369 FAV---------------------------------------LDSINNIIT-------------- 380
            |::                                       |:.|...||
Human   949 FSLYSYCYSSFNIQIGSEEEVYISHIYSPQKFYCQLGRNNKDLEMIETKITESVNLQNFPKYDSN 1013

  Fly   381 --RITINS--------------SSAGGGYDAYLIDFGEHIHFDGNETIFKLPDDIKRL---PAQA 426
              |:.|:.              :.:...:..|.:|||.. ...|...:..:......|   |.||
Human  1014 KMRVCISKYVEDGLSYRALAIPTDSSSEFQVYFVDFGNK-QLVGENMLRAISAQFPELLFTPMQA 1077

  Fly   427 IRC---DLINCDI-ANMHC---------------------------------FVNTYIKIRVH-- 452
            |:|   ||.:.|| |.:..                                 ::|..||:.:|
Human  1078 IKCFLSDLRDVDIPAEISSWFKDNFLGRSLKAIILSQESDGQLGIELYDGSQYINEKIKVLLHAY 1142

  Fly   453 -----------ENNNSTLVAEPVIDRLSRPT----KTNTTKYPAGITEDDMAMLNEIDESTSDPL 502
                       |.:|.....:.....|...|    :.|....|:.:|..:    .:||:.
Human  1143 GKRHCDQACCMEKSNKINENKRFTTSLKGKTGNNYRHNVINKPSPVTYSE----RKIDQL----- 1198

  Fly   503 KAVLGFRPKD------EQRICRHYDP--------KLNGCFKGNNCRFAHEPFAPNGA-------- 545
                 ..||:      :..:|...:|        .||...||..       ..|..|
Human  1199 -----MHPKNIHARFLKPSVCYKMEPVSKNKMKTSLNDGLKGIK-------IVPGAAHILENRRV 1251

  Fly   546 -TKDVELA-----RALPETIFDTTV-------------HFEIGSIVGILITFINGPTEVYGQFLD 591
             .|.|::.     |||.:|......             ...:.:.|...::.|:.|...:.|..:
Human  1252 GQKSVKVVSQSFIRALNQTTSQNPYDLIRPQIKDLPQPQIYLNAKVKGYVSNISNPANFHIQLAE 1316

  Fly   592 GSPPLV--WDKKDVPENK-RTFKS-KPRLLDIVLALYS-DGCFYRAQIIDEFP-SEYMIFYVDYG 650
            ....::  .|..:....: |..|| ||.:.|:|:|.|| |...|||.|....| :.:.:.::|||
Human  1317 NESVIIRLADALNATARRLRERKSVKPLVGDLVVAEYSGDNAIYRAVIKKILPGNSFEVEFIDYG 1381

  Fly   651 NTEFVPLSCL---------APCENVDSF-------KPHRVFSFHIEGIVRSKNLTHQKTIECIEY 699
            |:..|..|.:         .|...:.:|       :|..::.........||  .|.||:.| |:
Human  1382 NSAIVNTSKIYELQREFLTVPQLGIHAFLSGVKWNEPDEIWDDKTVDYFTSK--VHNKTVYC-EF 1443

  Fly   700 LKSKLLNTEMNVHLVQRLPDGFLIRFLDDWKYIPEQLLQRNYAQVSQ 746
            ||......|:|:...::.    :|..|..||...:  ||::..|:.|
Human  1444 LKKHDQKWEVNMICDEKC----VINELLKWKACSK--LQKSALQMPQ 1484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	30/132 (23%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	17/54 (31%)
TDRD15	NP_001293066.1	TUDOR	535..580	CDD:119391
		TUDOR	759..867	CDD:278965	14/115 (12%)
		TUDOR	806..848	CDD:119391	6/41 (15%)
		TUDOR	961..1084	CDD:278965	17/123 (14%)
		TUDOR	1017..1062	CDD:119391	6/45 (13%)
		TUDOR	1291..1412	CDD:278965	29/120 (24%)
		TUDOR	1346..1393	CDD:119391	17/46 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1490..1510
		TUDOR	1524..1641	CDD:278965
		TUDOR	1578..1624	CDD:119391
		TUDOR	1740..1852	CDD:278965
		TUDOR	1784..>1820	CDD:119391
		TUDOR	237..356	CDD:278965
		TUDOR	293..339	CDD:119391
		TUDOR	479..600	CDD:278965	1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.000