Protein Alignment krimp and TDRD15

DIOPT Version :10

• Sequence 1: NP_611103.2
• Gene: krimp / 36804
• FlyBaseID: FBgn0034098
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_001293066.1
• Gene: TDRD15 / 100129278
• HGNCID: 45037
• Length: 1934
• Species: Homo sapiens
• Alignment Length: 957
• Identity: 172/957 - (17%)
• Similarity: 305/957 - (31%)
• Gaps: 322/957 - (33%)

  Fly    42 LSH----ADLLYRSLIPLHDHLVASLSEVNAHVMKLNVQLHINRQSVRLGDYEYYEKSIDNPYSS 102
            |:|    .||..::.|.....||.:.:.:...:.|.:.:..:|.|||...:      :||    .
Human   598 LAHIFPVEDLWTKAAIDYFKKLVLNKAILLQVIAKKDDKYTVNIQSVEASE------NID----V 652

  Fly   103 IRSGLQAIEKPGCAEAICQSSKPAFVECLPSSTSEEVPVVAVQEASSTNQLDAISVV-------- 159
            |...|||    |.||..     ...:|..|.|.||    .::..:.|.|:::...|:
Human   653 ISLMLQA----GYAEYF-----QVELEYFPKSVSE----YSMLNSESKNKVNIKKVISALLEGPK 704

  Fly   160 -----NENLSEERDATPQPLAVSKNMEE-----TMPSNP-------------------------- 188
                 :.||.|...:.|:.|||  |:.|     |:...|
Human   705 SKKYHSNNLVENNLSLPKSLAV--NISEFKNPFTLSVGPESSWPYKEYIFRPGTVLEVKCSCYYG 767

  Fly   189 ---FHEQLEGSLEEIPVGSKIVVETEKANNPVRSEASAPATSDNQSLLAAKQGTQTIGTGICNKI 250
               |..||:...|::    |:::|..:....:.|:    .....|:...||...:.....:..::
Human   768 PGDFSCQLQCKSEDL----KLLMEQIQNYYSIHSD----PYEIGQTACVAKYSGKWCRAAVLTQV 824

  Fly   251 SKST--INMPNNWQ----LENPTEVTAASIEKVNKLPKSPRNRFLLPPK----GGTETTRRDIYN 305
            ||..  :.:...:|    :|:...:....:...::..:...|.|:.|..    ..|....||::|
Human   825 SKEVDIVFVDYGYQKRVLIEDLCAINPRFLLLESQAFRCCLNHFIEPVSCKLFSWTRKAFRDLWN 889

  Fly   306 QILKDMAAFPENTIVTAVL-ASVDVTDNCAY-VAKWDESSDRIKKVLQRQLPLQELDQLPDYGDI 368
            .|.....      ::|.:: |.|.:..|..| :.....|....|:.|..:...|.:.....:..:
Human   890 FISSSRG------LLTCIIYALVIIHPNHLYNLVDLQSSFTSAKEFLMNRGSAQYITLSETFPSL 948

  Fly   369 FAV---------------------------------------LDSINNIIT-------------- 380
            |::                                       |:.|...||
Human   949 FSLYSYCYSSFNIQIGSEEEVYISHIYSPQKFYCQLGRNNKDLEMIETKITESVNLQNFPKYDSN 1013

  Fly   381 --RITINS--------------SSAGGGYDAYLIDFGEHIHFDGNETIFKLPDDIKRL---PAQA 426
              |:.|:.              :.:...:..|.:|||.. ...|...:..:......|   |.||
Human  1014 KMRVCISKYVEDGLSYRALAIPTDSSSEFQVYFVDFGNK-QLVGENMLRAISAQFPELLFTPMQA 1077

  Fly   427 IRC---DLINCDI-ANMHC---------------------------------FVNTYIKIRVH-- 452
            |:|   ||.:.|| |.:..                                 ::|..||:.:|
Human  1078 IKCFLSDLRDVDIPAEISSWFKDNFLGRSLKAIILSQESDGQLGIELYDGSQYINEKIKVLLHAY 1142

  Fly   453 -----------ENNNSTLVAEPVIDRLSRPT----KTNTTKYPAGITEDDMAMLNEIDESTSDPL 502
                       |.:|.....:.....|...|    :.|....|:.:|..:    .:||:.
Human  1143 GKRHCDQACCMEKSNKINENKRFTTSLKGKTGNNYRHNVINKPSPVTYSE----RKIDQL----- 1198

  Fly   503 KAVLGFRPKD------EQRICRHYDP--------KLNGCFKGNNCRFAHEPFAPNGA-------- 545
                 ..||:      :..:|...:|        .||...||..       ..|..|
Human  1199 -----MHPKNIHARFLKPSVCYKMEPVSKNKMKTSLNDGLKGIK-------IVPGAAHILENRRV 1251

  Fly   546 -TKDVELA-----RALPETIFDTTV-------------HFEIGSIVGILITFINGPTEVYGQFLD 591
             .|.|::.     |||.:|......             ...:.:.|...::.|:.|...:.|..:
Human  1252 GQKSVKVVSQSFIRALNQTTSQNPYDLIRPQIKDLPQPQIYLNAKVKGYVSNISNPANFHIQLAE 1316

  Fly   592 GSPPLV--WDKKDVPENK-RTFKS-KPRLLDIVLALYS-DGCFYRAQIIDEFP-SEYMIFYVDYG 650
            ....::  .|..:....: |..|| ||.:.|:|:|.|| |...|||.|....| :.:.:.::|||
Human  1317 NESVIIRLADALNATARRLRERKSVKPLVGDLVVAEYSGDNAIYRAVIKKILPGNSFEVEFIDYG 1381

  Fly   651 NTEFVPLSCL---------APCENVDSF-------KPHRVFSFHIEGIVRSKNLTHQKTIECIEY 699
            |:..|..|.:         .|...:.:|       :|..::.........||  .|.||:.| |:
Human  1382 NSAIVNTSKIYELQREFLTVPQLGIHAFLSGVKWNEPDEIWDDKTVDYFTSK--VHNKTVYC-EF 1443

  Fly   700 LKSKLLNTEMNVHLVQRLPDGFLIRFLDDWKYIPEQLLQRNYAQVSQ 746
            ||......|:|:...::.    :|..|..||...:  ||::..|:.|
Human  1444 LKKHDQKWEVNMICDEKC----VINELLKWKACSK--LQKSALQMPQ 1484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	576..679	CDD:425754	29/124 (23%)
		Tudor_dTUD-like	618..663	CDD:410450	17/55 (31%)
TDRD15	NP_001293066.1	Tudor_TDRD15_rpt1	14..160	CDD:410507
		Tudor_TDRD15_rpt2	239..358	CDD:410508
		Tudor_TDRD15_rpt3	478..618	CDD:410509	5/19 (26%)
		Tudor_TDRD15_rpt4	747..868	CDD:410510	15/128 (12%)
		Tudor_TDRD15_rpt5	956..1082	CDD:410511	17/126 (13%)
		Tudor_TDRD15_rpt6	1306..1413	CDD:410512	27/106 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1490..1510
		Tudor_TDRD15_rpt7	1526..1678	CDD:410513
		TUDOR	1740..1852	CDD:425754