DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment krimp and Tdrd7

DIOPT Version :9

Sequence 1:	NP_611103.2	Gene:	krimp / 36804	FlyBaseID:	FBgn0034098	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001277404.1	Gene:	Tdrd7 / 100121	MGIID:	2140279	Length:	1119	Species:	Mus musculus

Alignment Length:	670	Identity:	139/670 - (20%)
Similarity:	222/670 - (33%)	Gaps:	241/670 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 PF----HEQLEGSLEEIPVGSKIVVETEKANNPVRSEAS--------APATSDNQSL--LAAKQG 238
            ||    :..||..|..:|.             .||.|||        |.|.::...:  |.|:|.
Mouse    73 PFKQLGYPTLEAYLRSVPA-------------VVRIEASRSGEIVCYAVACTETARIAQLVARQR 124

  Fly   239 T--QTIGTGI-CN-KISKSTINMPNNWQLENPTEVTA-----ASIEKVNKLPKSPRNRFLLPPKG 294
            |  :.||..| |. ::.|:   ||  :.||...:.|.     ||...:::.|    |..||..:|
Mouse   125 TSKRKIGRQINCQMRVKKA---MP--FFLEGKPKATLRQPGFASDYSISRKP----NSALLRDRG 180

  Fly   295 GTETTRRDIYNQILKDMAAFPENTI--------------VTAVLAS----------VDVTDN--- 332
            .....:.|:      ||..:|:..:              .:::.||          .:|.||
Mouse   181 SALGVKADV------DMPPYPDTPVQRHASMSANSRFSPKSSLPASFQTHISRACPTEVNDNLNQ 239

  Fly   333 ----------CAYVAKWDESSDRIKKVLQRQLPLQELDQLPDYGDIFAVLDSINNIITR------ 381
                      .:|..|.||..:|||::|.:......:.:||.:...|...|....::.:
Mouse   240 TVEKPNITPPASYTNKMDEVQNRIKEILDKHNNGIWISKLPHFYKEFYKEDLNQGVLQQFEHWPH 304

  Fly   382 ITINSSSAGGGYDAYLIDFGEHIHFDGNETIFKLPDDIKRLP--------------AQAIRCDLI 432
            |.......|||.|:.|...........::      |..|.||              :.|:..|
Mouse   305 ICTVEKPCGGGQDSLLYPARREQPLKSDQ------DPEKELPPPPPAPKQEVPSQGSPAVMPD-- 361

  Fly   433 NCDIANMHCFVNTYIKIRVHE---NNNSTLVAEPVIDRLSRPTKTNTTKYPAGITED-------- 486
                          :|.:|.|   ..:|.|.|       |...|.....|.....||
Mouse   362 --------------VKEKVAELLGKYSSGLWA-------SALPKAFEDMYKVKFPEDALKNLASL 405

  Fly   487 -DMAMLNEIDESTSDPLKAVLGFR---P-----KDEQRICRHYDPKLNGCFKGNNCRFAHEPFAP 542
             |:..:|.|..:|.   ||:|..:   |     |||.:....:|.|              .....
Mouse   406 SDVCTINYISGNTQ---KAILYAKLPLPTDKILKDEGQAQGDFDIK--------------SMIEQ 453

  Fly   543 NGATKDVELARALPETIFDTTVH--------------FEIGSIVGILITFINGPTEVYGQFLDGS 593
            .....:..:|.:..|.:.|.||.              .|:.:...::|.::       |:....:
Mouse   454 EYLQIEKNMAESADEFLEDITVPPLVIPTEASPSVLVVELSNTNDVVIRYV-------GKDYSAA 511

  Fly   594 PPLVWDKKDVPENKRTFKSKPRLLDI-------VLALYS-DGCFYRAQIIDEFPSEYMIFYVDYG 650
            ..|:.|     |.|..:...||:..|       :||:.: :..:.|||||....::..:.|||||
Mouse   512 QELMED-----EMKEFYSKNPRVTPIQTVHVGQLLAVNAEEDAWLRAQIISTDENKIKVCYVDYG 571

  Fly   651 NTEFVPLSCLAPCENVDSFKPHRVFSFHIEGIVRSKNLTHQKTIECIEYLKSKLLNTE-MN---- 710
            .           |||::..|.:|:..       |..:|:.|.|       |.||...| :|
Mouse   572 F-----------CENIEKSKAYRLNP-------RFCSLSFQAT-------KCKLAGLEVLNDDPD 611

  Fly   711 -VHLVQRLPDG--FLIRFLD 727
             |..|:.|..|  |.:..||
Mouse   612 LVKAVESLTCGKIFAVEILD 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
krimp	NP_611103.2	TUDOR	568..679	CDD:278965	26/118 (22%)
krimp	NP_611103.2	TUDOR	618..662	CDD:119391	13/51 (25%)
Tdrd7	NP_001277404.1	LOTUS_1_TDRD7	38..124	CDD:193600	15/63 (24%)
		LOTUS_2_TDRD7	256..322	CDD:193587	16/65 (25%)
		LOTUS_3_TDRD7	361..425	CDD:193588	19/89 (21%)
		TUDOR	480..602	CDD:278965	34/158 (22%)
		TUDOR	538..580	CDD:119391	15/52 (29%)
		TUDOR	669..796	CDD:278965
		TUDOR	728..773	CDD:119391
		TUDOR	932..1047	CDD:278965
		TUDOR	984..1028	CDD:119391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1525
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22948
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000