DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf3 and MELTF

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	XP_011511152.1	Gene:	MELTF / 4241	HGNCID:	7037	Length:	765	Species:	Homo sapiens

Alignment Length:	769	Identity:	170/769 - (22%)
Similarity:	271/769 - (35%)	Gaps:	168/769 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WLTLILVGLFASFLSISMCVAVQPPDD--GKLRVCVVESRGVYRKTPKFCPLLEAKSNIECVIGV 65
            ||.|.|..:... :.:..|....|...  |.:.....|: |:             :.::.||.|.
Human     9 WLLLALRTVLGG-MEVRWCATSDPEQHKCGNMSEAFREA-GI-------------QPSLLCVRGT 58

  Fly    66 DRLDCVRRIHKGTAHFGVLTSEDLVAARWASVEIL----------------VASELRSHESHFEY 114
            ....||:                |:||:.|....|                |..|:...|....|
Human    59 SADHCVQ----------------LIAAQEADAITLDGGAIYEAGKEHGLKPVVGEVYDQEVGTSY 107

  Fly   115 EIVAVVDNHANIHTVHDLRGARLCHPGYGLGNHWTEVLANYFEAAMVS-KTCDPEMTVTEDRIAS 178
            ..||||...::: |:..|:|.:.||.|......|...:....|:..:| ..||....|::
Human   108 YAVAVVRRSSHV-TIDTLKGVKSCHTGINRTVGWNVPVGYLVESGRLSVMGCDVLKAVSD----- 166

  Fly   179 TAKYFGPSCKAGPWVPDPKQDRILKNRYPSLCEMCYEPDS----CDQT--DKHWGRRGALYCLTS 237
               |||.||..|.......:         |||.:|....|    ||::  ::::...||..||..
Human   167 ---YFGGSCVPGAGETSYSE---------SLCRLCRGDSSGEGVCDKSPLERYYDYSGAFRCLAE 219

  Fly   238 GGGNVAWARLDDVRSHFGFSGIPAQSN---PSDFSYLCPDGHLQPLNASQPCVWVAKPWPVVAAR 299
            |.|:||:.:...|..:.....:|:...   ..||..||.||....:...:.|.....|...|..|
Human   220 GAGDVAFVKHSTVLENTDGKTLPSWGQALLSQDFELLCRDGSRADVTEWRQCHLARVPAHAVVVR 284

  Fly   300 R-SHAAQVQRLVT---GLNHDEPDSWQNALLSLLETYH----VFTVPLDNVIAIDDYLDQATAFQ 356
            . :....:.||:.   .|...|..|:|   :...|.|.    :|......::.|      ||...
Human   285 ADTDGGLIFRLLNEGQRLFSHEGSSFQ---MFSSEAYGQKDLLFKDSTSELVPI------ATQTY 340

  Fly   357 SAYSFPE---------CNP---PRSIVFCTTSIIQHIKCSWLQEASQVYGVQPNIQCVRTMDEQQ 409
            .|:...|         |:|   |..:.:|..|..:..||..:..|.:...::|.||||.....|.
Human   341 EAWLGHEYLHAMKGLLCDPNRLPPYLRWCVLSTPEIQKCGDMAVAFRRQRLKPEIQCVSAKSPQH 405

  Fly   410 CLDNTKFKETDVVLVDQEMRVKAQRDYNLVPLLYEFAA--DMHDRYVTIALVHKDAKFE-SFRDL 471
            |::..:.::.|.|.:..|....|.:.|.|||...|..|  |..:.|..:|:|.:|:... :..:|
Human   406 CMERIQAEQVDAVTLSGEDIYTAGKTYGLVPAAGEHYAPEDSSNSYYVVAVVRRDSSHAFTLDEL 470

  Fly   472 KGARACLPSFEGAAHLSVQETIVNATGKVQ--------SLHSYFHRDS----------------C 512
            :|.|:|...|...|...|....:...|.::        ::..:|:...                |
Human   471 RGKRSCHAGFGSPAGWDVPVGALIQRGFIRPKDCDVLTAVSEFFNASCVPVNNPKNYPSSLCALC 535

  Fly   513 LWNLQSGRKC----PLHYQGDEGALRCLSEGA-DVAFLSSDVYKKYVVGNLTSNWLTPGNHKDFR 572
            :.:.|...||    ...|.|..||.|||.|.| ||||:..........|:.:..|......:|:.
Human   536 VGDEQGRNKCVGNSQERYYGYRGAFRCLVENAGDVAFVRHTTVFDNTNGHNSEPWAAELRSEDYE 600

  Fly   573 VLCPYGGIEKRSNFEYCYLHWTTRGHLMTHNSSLTRRNEIYNSLRDMDQLFGRKYKSETRPFTLY 637
            :|||.|...:.|.|..|.|.......:|.                          :.:|..||:|
Human   601 LLCPNGARAEVSQFAACNLAQIPPHAVMV--------------------------RPDTNIFTVY 639

  Fly   638 GIFDKRNNVLFRDDTDGLLGLQELHRDN--AKRVMEHIYDRYANTQYYRNFDES 689
            |:.||...  |.....|.:.|.|...:.  ..|..:.::....|...::.||.|
Human   640 GLLDKAQQ--FAASGTGRVTLPEPSEEQVVCLRCFQDLFGDDHNKNGFKMFDSS 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	81/380 (21%)
		PBP2_transferrin	369..681	CDD:270247	78/345 (23%)
		TR_FER	370..656	CDD:214514	74/317 (23%)
MELTF	XP_011511152.1	Transferrin	23..357	CDD:278817	82/390 (21%)
		PBP2_transferrin	23..355	CDD:270247	82/388 (21%)
		TR_FER	367..733	CDD:214514	81/353 (23%)
		PBP2_transferrin	367..731	CDD:270247	81/353 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11485
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880