DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsf3 and tfa

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001278428.1	Gene:	tfa / 30255	ZFINID:	ZDB-GENE-980526-35	Length:	673	Species:	Danio rerio

Alignment Length:	733	Identity:	166/733 - (22%)
Similarity:	283/733 - (38%)	Gaps:	149/733 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSISMCVAVQPPD---DGKLRVCVVESRGVYRKTPKFCPLLEAK-SNIECVIGVDRLDCVRRIHK 76
            :|:..|:.|..|.   ..|::.||..     :.....|..|..| ::|||.:....:||:|.|..
Zfish     6 ISLLGCLVVALPSASAQKKVKWCVTT-----QNEQSKCRHLATKAADIECHLQPTVIDCMRSIAA 65

  Fly    77 GTAHFGVLTSEDLVAARWASV------EILVASELRSHESHFEYEIVAVVDNHANIHTVHDLRGA 135
            |        ..|:|....|:|      ..|:...:...:....|.:.||  ...:...:::|:|.
Zfish    66 G--------GTDIVTVDGANVFTGGLNNYLLRPIIAEKKKECCYAVAAV--KAGSGFNINELKGK 120

  Fly   136 RLCHPGYGLGNHWTEVLANYFEAAMVSKTCDPEMTVTEDRIASTAKYFGPSCKAGPWVPDPKQDR 200
            ..||..|.....|...:........::.....||.|..    :.:::|..||..|
Zfish   121 SSCHSCYQRSGGWNTPIGKLIATNKITWEGPNEMPVER----AVSEFFSSSCVPG---------- 171

  Fly   201 ILKNRYPSLCEMCYEPDSCDQTDKHWGRRGALYCLTSGGGNVAWARLDDVRSHFGFSGIPAQSNP 265
            :.|.:||:||:.|....||...:|::|..||..||.:..|.||:     |..|    .|| :|..
Zfish   172 VSKPKYPNLCKACQGDCSCSHNEKYFGDDGAFQCLKNDNGQVAF-----VCHH----AIP-ESER 226

  Fly   266 SDFSYLCPDGHLQPLNASQPCVWVAKPWPVVAARRSHAAQV------QRLVTGLNHDEPDSWQNA 324
            .::..||.||..:.:...:.|.:..:|...|.||.....|.      |...:.|...:....::.
Zfish   227 QNYELLCMDGSRKSVEDYKTCNFAREPARTVIARTDTDLQYVYDVLKQIPASDLFSSQAFGGKDL 291

  Fly   325 LLSLLETYHVFTVP--LDNVIAI-DDYLDQATAFQSAYSFPECNP--PRS---IVFCTTSIIQHI 381
            :.|...| .:..:|  .|:::.: ::|      :::..:|.:.||  |.|   :..||....:..
Zfish   292 IFSDSAT-ELMLLPKRTDSLLYLKEEY------YEAMQAFKDGNPSAPTSQTKLAMCTIGHAEKN 349

  Fly   382 KCSWLQEASQVYGVQPNIQCVRTMDEQQCLDNTKFKETDVVLVDQEMRVKAQRDYNLVPLLYEFA 446
            ||..|....:        .|:.......|::..|.||.|.:.||.. :|.......|||::.|.:
Zfish   350 KCDSLDHVKK--------SCILEASVDDCIEKIKRKEADFLAVDGG-QVYIAGKCGLVPVMAEQS 405

  Fly   447 ADMH--------DRYVTIALVHKDAKFESFRDLKGARACLPSFEGAAHLSVQETIVNATGKVQSL 503
            ....        ..|..:|:|.|.:.. ::.:|:|.::|......:|...:.|:.:.......:|
Zfish   406 NSQSCSSGSGGTASYYAVAVVRKGSGL-TWNNLEGKKSCHTGLGRSAGWKIPESAICGEKDKCTL 469

  Fly   504 HSYFHR----------DSCLWNLQSGR------KC----PLHYQGDEGALRCLSEGA-DVAFLSS 547
            ..:|..          :.|.....||:      ||    ...|.|.:||.|||:|.| ||||:
Zfish   470 DKFFSEGCAPGADPTSNMCKLCKGSGKPVGDESKCKPSAEEQYYGYDGAFRCLAEKAGDVAFI-- 532

  Fly   548 DVYKKYVVGNLT----SNWLTPGNHKDFRVLCPY--GGIEKRSNFEYCYLHWTTRGHLMTHNSSL 606
               |..|||:.|    .:|......:||.::||.  ....|.::||.|.|.......::|...:
Zfish   533 ---KHTVVGDYTDGKGKDWAKDLKSEDFELICPNTPDTTMKYTDFEKCNLAQVPVHAVITREDA- 593

  Fly   607 TRRNEIYNSLRDM----DQLFGRKYKSETRPFTLYGIFDKRNNVLFRDDTDGLLGLQELHR--DN 665
              |:.:.:.|.|:    :.||..|               ...|:||   |||...|||:..  |:
Zfish   594 --RSAVVSFLSDIQSKNNDLFTSK---------------DGKNLLF---TDGTKCLQEIKGSVDD 638

  Fly   666 --AKRVMEHIYDRYANTQ 681
              .|:.::.|...|..:|
Zfish   639 FLTKKYIDMIERTYKTSQ 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	76/352 (22%)
		PBP2_transferrin	369..681	CDD:270247	83/357 (23%)
		TR_FER	370..656	CDD:214514	75/324 (23%)
tfa	NP_001278428.1	Periplasmic_Binding_Protein_Type_2	25..325	CDD:304360	73/345 (21%)
		TR_FER	25..322	CDD:214514	73/342 (21%)
		Periplasmic_Binding_Protein_Type_2	336..648	CDD:304360	80/347 (23%)
		TR_FER	341..653	CDD:214514	81/347 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920