DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf3 and Ltf

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_001100334.1	Gene:	Ltf / 301034	RGDID:	1305445	Length:	709	Species:	Rattus norvegicus

Alignment Length:	780	Identity:	167/780 - (21%)
Similarity:	283/780 - (36%)	Gaps:	212/780 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FLSISMCVAVQPP----DDGKLRVCVVESRGVYRKTPKFCPLLEAKSNIECVIGVDRLDCVRRIH 75
            |:::.|.:.|..|    .|..:|.|.: ||...:|    |.:.:...|   ..||.:|.|.|:
  Rat     4 FITVLMFLGVLGPFLARIDTVVRWCTI-SRNEAQK----CFMWQEMLN---KAGVPKLRCARK-- 58

  Fly    76 KGTAHFGVLTSEDLVAARWASVEIL---------------VASEL--RSHESHFEYEIVAVVDNH 123
                :|.....::::..|..::.:.               :|:|:  ...:....|..||||.|.
  Rat    59 ----YFMPHCIQEIMMRRADAMTLSGSAIFDFYFPYKLQPIAAEVYGTKEKPRIHYYAVAVVKNS 119

  Fly   124 ANIHTVHDLRGARLCHPGYGLGNHWTEVLANYFEAAMVSKTCDPEMTVTEDRIA---STAKYFGP 185
            ::|. ::.|:|.:.||.|:.....|...|.          ...|.:...|..::   :.:|:|..
  Rat   120 SDIR-LNQLQGLKSCHAGFDTSAGWIAPLG----------ALRPYLNWDEKSVSLEEAVSKFFSQ 173

  Fly   186 SCKAGPWVPDPKQDRILKNRYPSLCEMCYEPDS--CD--QTDKHWGRRGALYCLTSGGGNVAWAR 246
            ||..|          |.|:|:|.||.:|.....  ||  ..:.:.|..||..||....|:||:.|
  Rat   174 SCVPG----------ISKSRFPRLCSLCAGKGEHICDFSPQEPYAGYAGAFRCLRDNAGDVAFIR 228

  Fly   247 LDDVRSHFGFSGIPAQSNPSDFSYLCPDGHLQPLNASQPCVWVAKPWPVVAARRSHAAQV-QRLV 310
            ...:     |..:|.::....:..||||...:|:...:.|               |.||: .|.|
  Rat   229 ESTI-----FEELPNEAEWDQYKLLCPDNTWKPVTEYKEC---------------HLAQIPSRAV 273

  Fly   311 TGLNHDEPDS--WQNALLSLLE---------TYHVFTVPL--------DNVI-------AIDDYL 349
            ......|.||  |:  ||.|.:         .:.:|...|        |:||       .::.:|
  Rat   274 VAHVRSEKDSAIWE--LLHLSQEMFGKNKTSKFELFGSYLGQKDLLFKDSVIGFVRVPFTVNVWL 336

  Fly   350 DQATAFQSAY-SFPECNP-----PRSIVFCTTSIIQHIKCSWLQEASQVYGVQPNIQCVRTMDEQ 408
            ....::..|. |..|...     ...|.:|.....:.:||......|     ...|.|:.....:
  Rat   337 YLTFSYIMALKSLKESKENVMALRARITWCAVGSEEKLKCDQWSRVS-----VGKITCISCTTTE 396

  Fly   409 QCLDNTKFKETDVVLVDQEMRVKAQRDYNLVPLLYEF-------AADMHDR----YVTIALVHKD 462
            ||:.:....:.|.:.:|......|.: ..|||:|.|.       .:|..||    |:.:|.|.|:
  Rat   397 QCIFSITMGDADAMNLDGGYIYSAGK-CGLVPVLAEIQKSPNSNGSDCVDRPAEGYLAVAAVRKE 460

  Fly   463 AKFESFRDLKGARACLPSFEGAAHLSVQET---------IVNATGKVQSLHSYFHRDS------- 511
            ....::..::|.::|        |.:|..|         :||.|...| ...:|::..
  Rat   461 DTGFTWSTVRGKKSC--------HTAVDRTAGWNIPMGLLVNQTNSCQ-FKEFFNKSCAPGSFLY 516

  Fly   512 ------CLWNLQSGRKC----PLHYQGDEGALRCLSEGA-DVAFLSSDVYKKYVVGNLTSNWLTP 565
                  |:.:.....||    ...|||..||.|||:|.| :||||......:...|.....|...
  Rat   517 SNLCALCIGDENGKDKCNPNSQERYQGYVGAFRCLAEKAGNVAFLKDATVLQNTDGKNADKWAKN 581

  Fly   566 GNHKDFRVLCPYGGIEKRSNFEYCYLHWTTRGHLMT---HNSSLTRRNEIYNSLRDMDQLFGRK- 626
            ....||.:||.....:..:..:.|:|. ....|.:.   ..:.|.::..:|..::     |||.
  Rat   582 LKLDDFELLCLDDTRKPVTEAKNCHLA-VAPNHAVVARKDKARLVQQELLYQQVQ-----FGRNG 640

  Fly   627 ---------YKSETRPFTLYGIFDKRNNVLFRDDTDGLLGLQELHRDNAKRVMEHIYDRYANTQY 682
                     ::|||:            |:||.|:|:.|          ||...:..::.|...:|
  Rat   641 CRCPEEFCLFRSETK------------NLLFNDNTECL----------AKLPSKITWEEYLGKEY 683

Fly 683 682
Rat 684 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	84/391 (21%)
		PBP2_transferrin	369..681	CDD:270247	77/362 (21%)
		TR_FER	370..656	CDD:214514	73/336 (22%)
Ltf	NP_001100334.1	Periplasmic_Binding_Protein_Type_2	24..350	CDD:304360	83/382 (22%)
		Transferrin	25..351	CDD:278817	83/382 (22%)
		PBP2_transferrin_C	360..691	CDD:270335	78/367 (21%)
		TR_FER	363..692	CDD:214514	78/364 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780