DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsf3 and Ltf

DIOPT Version :9

Sequence 1:	NP_523759.1	Gene:	Tsf3 / 36800	FlyBaseID:	FBgn0034094	Length:	714	Species:	Drosophila melanogaster
Sequence 2:	NP_032548.2	Gene:	Ltf / 17002	MGIID:	96837	Length:	707	Species:	Mus musculus

Alignment Length:	751	Identity:	167/751 - (22%)
Similarity:	274/751 - (36%)	Gaps:	181/751 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LRVCVVESRGVYRKTPKFCPLLEAKSNIE---CV--------IGVDRLDCVRRIHKGTAHFGVLT 85
            |.:|:.::     .|.::|    |.||.|   |:        :|...|.||::.........::|
Mouse    14 LGLCLAKA-----TTVQWC----AVSNSEEEKCLRWQNEMRKVGGPPLSCVKKSSTRQCIQAIVT 69

  Fly    86 SE-DLVA---------------ARWASVEILVASEL-RSHESHFEYEIVAVVDNHANIHTVHDLR 133
            :. |.:.               .|..:.|:....|. |:|     |..||||.|.:|.| ::.|:
Mouse    70 NRADAMTLDGGTMFDAGKPPYKLRPVAAEVYGTKEQPRTH-----YYAVAVVKNSSNFH-LNQLQ 128

  Fly   134 GARLCHPGYGLGNHW---TEVLANYFEAAMVSKTCDPEMTVTEDRIASTAKYFGPSCKAGPWVPD 195
            |.|.||.|.|....|   ...|..|.      ....|..::.|    :.:|:|..||     ||.
Mouse   129 GLRSCHTGIGRSAGWKIPIGTLRPYL------NWNGPPASLEE----AVSKFFSKSC-----VPG 178

  Fly   196 PKQDRILKNRYPSLCEMC--YEPDSCDQT--DKHWGRRGALYCLTSGGGNVAWARLDDVRSHFGF 256
            .::|     |:|:||..|  ...:.|..:  :.:.|..|||.||....|:||:.|...|     |
Mouse   179 AQKD-----RFPNLCSSCAGTGANKCASSPEEPYSGYAGALRCLRDNAGDVAFTRGSTV-----F 233

  Fly   257 SGIPAQSNPSDFSYLCPDGHLQPLNASQPCVWVAKPWPVVAARRSHAAQV--------------Q 307
            ..:|.::....:..||||...:|:...:.|.....|...|.:|.::..:.              :
Mouse   234 EELPNKAERDQYKLLCPDNTWKPVTEYKECHLAQVPSHAVVSRSTNDKEEAIWELLRQSQEKFGK 298

  Fly   308 RLVTGLNHDEPDSWQNALLSLLETYHVFTVPLDNVIAIDDYLDQATAFQSAYSFPECNPPRS--- 369
            :..:|.......|.|..||..........||  ..:.:..||    .|....|....|..:.
Mouse   299 KQASGFQLFASPSGQKDLLFKESAIGFVRVP--QKVDVGLYL----TFSYTTSIQNLNKKQQDVI 357

  Fly   370 -----IVFCTTSIIQHIKCSWLQEASQVYGVQPNIQCVRTMDEQQCLDNTKFKETDVVLVDQEMR 429
                 :.:|.....:..||.....||     :..:.|:.....:.|:......:.|.:.:|....
Mouse   358 ASKARVTWCAVGSEEKRKCDQWNRAS-----RGRVTCISFPTTEDCIVAIMKGDADAMSLDGGYI 417

  Fly   430 VKAQRDYNLVPLLYE-------FAADMHDR----YVTIALVHK-DAKFESFRDLKGARACLPSFE 482
            ..|.: ..|||:|.|       ...|..:|    |:.:|.|.: ||.| ::..|:|.::|
Mouse   418 YTAGK-CGLVPVLAENQKSSKSNGLDCVNRPVEGYLAVAAVRREDAGF-TWSSLRGKKSC----- 475

  Fly   483 GAAHLSVQET---------IVNATGKVQSLHSYFHRDS-------------CLWNLQSGRKCPLH 525
               |.:|..|         :.|.|...: .:.:|.:..             |:.:.:...||..:
Mouse   476 ---HTAVDRTAGWNIPMGLLANQTRSCK-FNEFFSQSCAPGADPKSNLCALCIGDEKGENKCAPN 536

  Fly   526 ----YQGDEGALRCLSEGA-DVAFLSSDVYKKYVVGNLTSNWLTPGNHKDFRVLCPYGGIEKRSN 585
                |||..||||||:|.| :||||......:...|..|..|......|||.:||.....:..:.
Mouse   537 SKERYQGYTGALRCLAEKAGNVAFLKDSTVLQNTDGKNTEEWARNLKLKDFELLCLDDTRKPVTE 601

  Fly   586 FEYCYLHWTTRGHLMTHNSSLTRRNE----IYNSLRDMDQLFGRKYKSETRPFTLYGIFDKRNNV 646
            .:.|:|       .:..|.::..|.:    :...|.|....|||..:.....|.|:.  .|..|:
Mouse   602 AKNCHL-------AIAPNHAVVSRTDKVEVLQQVLLDQQVQFGRNGQRCPGEFCLFQ--SKTKNL 657

  Fly   647 LFRDDTDGLLGLQELHRDNAKRVMEHIYDRYANTQY 682
            ||.|:|:.|          ||...:...::|...:|
Mouse   658 LFNDNTECL----------AKIPGKTTSEKYLGKEY 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsf3	NP_523759.1	PBP2_transferrin	33..368	CDD:270247	86/383 (22%)
		PBP2_transferrin	369..681	CDD:270247	79/362 (22%)
		TR_FER	370..656	CDD:214514	75/328 (23%)
Ltf	NP_032548.2	PBP2_transferrin_N	23..349	CDD:270336	84/366 (23%)
		Transferrin	24..351	CDD:278817	83/367 (23%)
		PBP2_transferrin_C	361..691	CDD:270335	80/358 (22%)
		TR_FER	363..692	CDD:214514	80/356 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KI0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125278at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780