DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITGA9 and YJL132W

DIOPT Version :10

Sequence 1:NP_002198.2 Gene:ITGA9 / 3680 HGNCID:6145 Length:1035 Species:Homo sapiens
Sequence 2:NP_012403.1 Gene:YJL132W / 853309 SGDID:S000003668 Length:750 Species:Saccharomyces cerevisiae


Alignment Length:744 Identity:141/744 - (18%)
Similarity:242/744 - (32%) Gaps:270/744 - (36%)


- Green bases have known domain annotations that are detailed below.


Human   147 KNIYY---EADHILPHGFCYIIPSNLQAKG--------RTLIPCYEEYKKKYGEE------HGS- 193
            |..||   :|....|.......|||.....        ..|:.....:::|||:.      ||| 
Yeast    44 KENYYPWLKAGSFFPDALYSCAPSNKDWSDFAEFTHWPNFLMIAVSYWQQKYGQNDRLRGTHGSL 108

Human   194 -CQAGIAGFFTEELVVMGAPGSFYW---------AGTIKVLNLTD--------NTYLKLNDEVIM 240
             .::.:.|.||.::|.:.      |         .|.::||:.|:        :|:|.:..|.:.
Yeast   109 ALKSFLIGVFTHQIVDVS------WHSLVTDYRMHGLLRVLSETEFDGDIETAHTFLDVMGEFLT 167

Human   241 ----------NRRYTYLGYAVTAGHFSHPSTIDVV-----GGAPQDK----------------GI 274
                      |..:.:|    |...:..|...|::     .|..::|                .|
Yeast   168 LNNVIRDSNNNENWDFL----TRSDWKLPREEDLMEIIRNAGLSKEKLSYAELEFCVKRGMAAAI 228

Human   275 GKVYIFRADRRSGTLIKIFQASGKK----MGSYFG--SSLCAVDLNGDGLSDLLVGAPMFSEI-R 332
            .:.|:||: :|:..|..|:..|.:.    :..:.|  |:|.|:         |....|.|..: .
Yeast   229 SEGYLFRS-QRNQLLTNIYSTSPRANDLILNHWLGGQSNLVAM---------LQRCVPFFETLFH 283

Human   333 DEGQVTVYINRGNGALEEQLALTGD----------------------GAYNAH-----------F 364
            ||..        |.|..|:|.|..:                      |  |:|           |
Yeast   284 DENT--------NEAQAEELRLCANLPPVSQKRINARPLVSSLKARKG--NSHIVVSPMKSFSDF 338

Human   365 GESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMKLSGQKINPVLRMFGQS 429
            |.|: ::.....|....:|:.||.||. .||:||...|...:..:....:    :.|:..|:|..
Yeast   339 GTSL-TMGKFREDNKDYLAVSAPLEDT-VGAIYIVPWDILTVARKEDFSI----LQPITAMYGSK 397

Human   430 I-----------------SGGIDMDGNGYPDVTV----------------GAFMSDSVVLLRARP 461
            :                 :..||....|...:|:                |.|..|.:      |
Yeast   398 VGTYKASDVDYLLVSQPGTCTIDFYFKGVKILTIKDETTEEAHQLQFAVTGNFYDDKI------P 456

Human   462 VITVD----------VSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLM 516
            .:.|.          ::.|:|||..|:.....|..|.|   :::|        ..|.|.|:    
Yeast   457 DLVVSSPSYGANETGIATFIPGSSIISYLTNSDKYQVV---DIST--------FKGVINLD---- 506

Human   517 ADVAKKEKGQMPRVYFVLLGET--MGQVTEKLQLTYMEETCRH---YVAHVKRRVQDVISPIVFE 576
                    |...::.|...|.|  :...|:|.:|.|:  ||:.   ...:....:.|:..||.:.
Yeast   507 --------GYPMKIPFQHFGATIQISDTTDKQKLIYI--TCQSLGTVFVYSSNDLHDLSIPIYYI 561

Human   577 AAYSL-----SEHVTGEEERELPPL------TPVLRWK-KGQKIAQKNQTVFER----------- 618
            ....:     |:||   |...:|..      ..:..|. :|......:|.:|:.           
Yeast   562 TKNGVIPAKDSDHV---EWHIIPSKEHGMFGAAIYSWNFEGMSFVAVSQPMFDTVFIYIEKSGQI 623

Human   619 ----------NCRSEDCAADLQLQGKLLLSSMDEKTLYL-------ALGAVKNISLNISISNLGD 666
                      ..:|:....:.   |..||.:.:||.||:       |.|::..||:: .:...|:
Yeast   624 EFFLKLVLKIKTKSDSIPDEF---GSSLLFNDEEKKLYVSSPGSFDARGSIWKISMD-ELLKAGN 684

Human   667 DAYDANVSFNVSRELFFINMWQKEEMGIS 695
            |.....:..|..|.|..||. .|...|:|
Yeast   685 DPKRKTLLINNLRHLMLINP-DKSSKGVS 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGA9NP_002198.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96
Int_alpha 44..101 CDD:214549
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 111..174 8/37 (22%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 182..232 16/74 (22%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 233..289 13/86 (15%)
Int_alpha 244..294 CDD:214549 13/70 (19%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 290..349 13/65 (20%)
Int_alpha 300..347 CDD:214549 10/49 (20%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 351..408 19/89 (21%)
Int_alpha 361..414 CDD:214549 16/63 (25%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 411..474 14/105 (13%)
Int_alpha 425..>466 CDD:214549 10/73 (14%)
Integrin_alpha2 460..903 CDD:462478 58/291 (20%)
GFFKR motif 1005..1009
YJL132WNP_012403.1 Zn_dep_PLPC 35..234 CDD:425927 36/199 (18%)
Int_alpha 334..>374 CDD:214549 13/41 (32%)
Blue background indicates that the domain is not in the aligned region.

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