DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ITGA9 and itga9

DIOPT Version :10

Sequence 1:NP_002198.2 Gene:ITGA9 / 3680 HGNCID:6145 Length:1035 Species:Homo sapiens
Sequence 2:NP_001311427.1 Gene:itga9 / 394012 ZFINID:ZDB-GENE-040426-1129 Length:1032 Species:Danio rerio


Alignment Length:1027 Identity:674/1027 - (65%)
Similarity:832/1027 - (81%) Gaps:9/1027 - (0%)


- Green bases have known domain annotations that are detailed below.


Human    12 RLRALLLALVVAGIP-AGAYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYS 75
            ::|||.:.:.:..:. |.::|:|.|.||.|:||..:||||:||||.||||||::||||:|:|.:|
Zfish    12 KIRALDVFVCLCSVSLAYSFNIDLQYPVVFRGPDATFFGYSVLEHVHDNTRWIVVGAPRANSSFS 76

Human    76 PSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRVL 140
            .||:|||||:|||:..||::||||:|:.||..:..||||||:.||:|||||||||||.|.:|::|
Zfish    77 SSVQSPGAVYKCRIRNNPEQRCTEMDLGRGNKQRESCGKTCQGDRNDEWMGVSLARQNKPNGKIL 141

Human   141 ACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYGEEHGSCQAGIAGFFTEE 205
            ||||||||:|||:::|||||:|.|||:|||.|.:.||||||::||.||||||||||||||.||||
Zfish   142 ACAHRWKNVYYESEYILPHGYCSIIPANLQGKSQPLIPCYEDHKKTYGEEHGSCQAGIAGVFTEE 206

Human   206 LVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGAPQ 270
            |||||||||:||.||:||.|:|.||:..||.:.:...||:||||||||||||.|:||||..||||
Zfish   207 LVVMGAPGSYYWTGTVKVFNMTSNTHYNLNQDDLSPHRYSYLGYAVTAGHFSSPNTIDVAAGAPQ 271

Human   271 DKGIGKVYIFRADRRSGT-LIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRDE 334
            |.|.||||:||.:   || |:||||||||.|||||||||||||||.||||||||||||.||||||
Zfish   272 DSGGGKVYVFRIE---GTALVKIFQASGKMMGSYFGSSLCAVDLNADGLSDLLVGAPMHSEIRDE 333

Human   335 GQVTVYINRGNGALEEQLALTGDGAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFAGAVYIY 399
            |||:||::.|||.:||...|.||.||||||||.|.||.|:|:||:.|||||||:|||:.||||||
Zfish   334 GQVSVYLSSGNGVMEEVAILNGDNAYNAHFGECITSLGDIDDDGYQDVAIGAPEEDDYGGAVYIY 398

Human   400 HGDAGGIVPQYSMKLSGQKINPVLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVIT 464
            ||||.|||.:|||:|||:.|||.|:||||||||.:|||||||||||:||||:|||||||:||||:
Zfish   399 HGDARGIVNKYSMRLSGRSINPTLQMFGQSISGNVDMDGNGYPDVTIGAFMADSVVLLRSRPVIS 463

Human   465 VDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPR 529
            ||||||||.|||||.||||:|.|.:||.|||.|.||.||||||.|.|.|.|.||..|:.||..||
Zfish   464 VDVSIFLPVSINITVPQCHEGPQHLNCFNVTVCMSFRGKHVPGHIELLYNLTADSDKRHKGLPPR 528

Human   530 VYFVLLGETMGQVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGE-EEREL 593
            .||...||..|.|:::..|....:.|..|.|.|::.|:||.:.|||||||||.:|:..| ::|:|
Zfish   529 AYFGNGGEQTGVVSQRFNLEIHRQQCHQYTAFVRKEVKDVFAAIVFEAAYSLGKHIVDEHQDRDL 593

Human   594 PPLTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEKTLYLALGAVKNISLN 658
            |||:|:||||||:|||.||:|.||:||.|:||||||||.||||||.....: :||||.|||:|||
Zfish   594 PPLSPILRWKKGEKIAAKNETWFEKNCLSDDCAADLQLHGKLLLSGRYISS-HLALGGVKNVSLN 657

Human   659 ISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYEFSV 723
            ::|||.||||||.|:.||.|:|:.:||..|:||.||||.|:|.|||||||||||||:::||..|.
Zfish   658 LTISNAGDDAYDTNIYFNFSKEVHYINFLQREEKGISCMLVELDFLKCSVGFPFMRAQTKYHISA 722

Human   724 IFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPTSFVYGESV 788
            :||||.||||.|.|.|:|.|:|.|.|...:||||||.|.:||:|||||:|||:::|||||||.||
Zfish   723 LFDTSRLSGENETLLFLVHARSANPEHDNTLHDNTLELSIPLVHEVDTTITGVVNPTSFVYGNSV 787

Human   789 DAANFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSSGGAEMFHVQEMVVGQEKG 853
            |.:.|:||:|:||.|||:|.|.||.|.|||.||||.|.|..|:||:..|.||||:.:..|...:|
Zfish   788 DRSRFVQLEDMECSFQPLNFTFQVINNGPSRLPGSRVDIRIPHRLAGSGPEMFHIIDTQVSDARG 852

Human   854 NCSFQKNPTPCIIPQEQENIFHTIFAFFTKSGRKVLDCEKPGISCLTAHCNFSALAKEESRTIDI 918
            ||::.:||.||.|||::|:|||||||||||||||||||::||.:|||..|:..:.||||:.:||:
Zfish   853 NCTWHRNPKPCTIPQDKESIFHTIFAFFTKSGRKVLDCDRPGRACLTISCSLGSQAKEEATSIDV 917

Human   919 YMLLNTEILKKDSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEALHNLEPRGYVVGWII 983
            .||||||||::||||||||::|..|::|.  |.||::.|.|:::::|.||||:.|||||||||||
Zfish   918 QMLLNTEILQRDSSSVIQFVTRGHVQLDD--RTVEVSSGLPDDISLVMEALHSQEPRGYVVGWII 980

Human   984 AISLLVGILIFLLLAVLLWKMGFFRRRYKEIIEAEKNRKENEDSWDWVQKNQ 1035
            ||||||||||||||||||||||||||.|:||||||||||::::|||||||:|
Zfish   981 AISLLVGILIFLLLAVLLWKMGFFRRHYREIIEAEKNRKDSDESWDWVQKSQ 1032

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGA9NP_002198.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96 39/60 (65%)
Int_alpha 44..101 CDD:214549 37/56 (66%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 111..174 46/62 (74%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 182..232 39/49 (80%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 233..289 35/56 (63%)
Int_alpha 244..294 CDD:214549 35/50 (70%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 290..349 49/58 (84%)
Int_alpha 300..347 CDD:214549 40/46 (87%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 351..408 40/56 (71%)
Int_alpha 361..414 CDD:214549 39/52 (75%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 411..474 51/62 (82%)
Int_alpha 425..>466 CDD:214549 34/40 (85%)
Integrin_alpha2 460..903 CDD:462478 271/443 (61%)
GFFKR motif 1005..1009 3/3 (100%)
itga9NP_001311427.1 Int_alpha 45..93 CDD:214549 31/47 (66%)
Int_alpha 245..293 CDD:214549 35/50 (70%)
Int_alpha 299..345 CDD:214549 39/45 (87%)
Int_alpha 360..413 CDD:214549 39/52 (75%)
Int_alpha 423..>465 CDD:214549 34/41 (83%)
Integrin_alpha2 459..907 CDD:462478 272/448 (61%)

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