Protein Alignment ITGA9 and ItgaPS4

DIOPT Version :10

• Sequence 1: NP_002198.2
• Gene: ITGA9 / 3680
• HGNCID: 6145
• Length: 1035
• Species: Homo sapiens
• Sequence 2: NP_611025.2
• Gene: ItgaPS4 / 36693
• FlyBaseID: FBgn0034005
• Length: 1069
• Species: Drosophila melanogaster
• Alignment Length: 1161
• Identity: 275/1161 - (23%)
• Similarity: 476/1161 - (40%)
• Gaps: 264/1161 - (22%)

Human    17 LLALVVAGIPA--GAYNLDPQRPVHFQGP------ADSFFGYAVLEHFHDNTRWVLVGAPKADSK 73
            ||.:|:..:.:  .|||:.|........|      ..|:||::::    ...:.::|.||:|:|.
  Fly     4 LLVIVLLALQSEINAYNISPYPNSVLNFPELEGNRRSSYFGFSLV----IREKSIMVAAPRANSS 64

Human    74 YSP--SVKSPGAVFKCRVHTNPDRRCTELDM-ARGKNRG-TSCGKTCREDRDDEWMGVSLARQPK 134
            ...  ::..||.:|:|  :......|:..:: .:|..:| .:.|....:::|..|:|.::....:
  Fly    65 LEAQRNISEPGVIFRC--YFESGNNCSPYNIDTKGNYKGMPNDGLLTAKNKDFRWLGGAMDGGTR 127

Human   135 ADGRVLACAHRWKNIYYEADHILPHGFCYII---PSN-------------------LQAKGRTLI 177
            ...:.|.||.|:.:|..|.|:  .:|.||.:   |.|                   |:.....||
  Fly   128 DSDKFLVCAPRFYSINNENDY--NNGMCYWLSDTPKNIDSTEVMEKWPLRIEKKQVLKLADTNLI 190

Human   178 PCYEEYKKKYGEEHGSCQAGIAGFFTEE--LVVMGAPGSFYWAGTIKVLNLTD------------ 228
            |.|     ..||      .|::...:::  .::|||||...|.|::.:.....
  Fly   191 PYY-----SMGE------LGLSAHVSDDNSKLLMGAPGIDQWKGSVHLKQEVPSIKTSSGRQRRG 244

Human   229 -NTYLKLND-----EVIMNRRYTYLGYAVTAGHF--SHPSTIDVVGGAPQ-DKGIGKVYIFRADR 284
             ||..|.|:     :......::|.||||::|:|  |:.||:..|..||: :...|:.|||  |.
  Fly   245 MNTNRKCNECNPEPKNFGQEEFSYFGYAVSSGYFDSSNLSTVLYVATAPRGNNQFGEAYIF--DI 307

Human   285 RSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIR---DEGQVTVYINRGNG 346
            ...::.|..:..|...|.|||.|:.|.||||||.:|:::.||::: :|   |:|.:.|:||:|:.
  Fly   308 YEDSIYKYHEFRGNHFGEYFGYSVLAEDLNGDGKTDVIISAPLYA-LRNSYDDGAIYVFINKGSF 371

Human   347 ALEEQLALTGDGAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFA--GAVYIYHGDAGGIVPQ 409
            ..||::..:..|: ...||.:::.:.|::.||:.|||:|||    ||  |:|:||.|...|:...
  Fly   372 TFEERIIRSPAGS-GGRFGTTLSRIGDINKDGYNDVAVGAP----FAGNGSVFIYLGSENGLRDP 431

Human   410 YSMKLSGQKINPV---LRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFL 471
            .|..|......|.   ..|||..:|.|.|:||||:.|..:||..:::|.|.||.||:.:..
  Fly   432 PSQCLDAPSQQPSKYGSYMFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKIHA---- 492

Human   472 PGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGL---NYVLMADVAKKEKGQMPRVYFV 533
                 |..|:..:.......:|:|.|:....|.......|   ..|:..|:..|.|     :...
  Fly   493 -----IIKPKLQNVNPEEERVNITVCYRLSSKSDSKAKALMEQELVIRIDIDTKSK-----IKLA 547

Human   534 LLGETMGQVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTG-----EEEREL 593
            :..|..|.........:.||.|..:...:.:|.:  .:||..|..|.||:.:..     |:...:
  Fly   548 VFDEEHGSQMSFKAKAFHEEICSEFQIEMDKRAK--FTPIALEMQYELSKKIPNSGDFCEDCAVV 610

Human   594 PPLTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEKTLYLALGAVKNISLN 658
            .|..|        |...:..| |...|.::.|.|||::       |....:..|.||....:.|.
  Fly   611 DPAEP--------KFVTEYIT-FNTGCATDVCVADLKI-------SCINASSTLVLGTTAVLRLT 659

Human   659 ISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRSKSKYE-FS 722
            .:|:|.|:.||....|...|..|      ...::..:|::.|: .:.|.:......:|...: .:
  Fly   660 YNITNNGEFAYHPKFSVTNSAGL------SLAQVPGNCKVNEA-VMVCDLNHGQRMAKGDTDSLT 717

Human   723 VIFDTSHLSG-----EEEVLSFIVTAQSGNTERSES-LHDNTLVLMVPLMHEVDTSITGIMSPTS 781
            :.||...|.|     :.||||          .|.|| ..:|.|..::.|..:.|..::|:.:...
  Fly   718 ISFDVRQLRGRSLEIQAEVLS----------ARDESNPENNKLTNVLSLREKADIYVSGVQTNDH 772

Human   782 FVYGESVDAANFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSISFP---------------- 830
            .|..||...|..:...:::.|             |||||...:||:..|
  Fly   773 VVLKESPYTAEVVNYYEIKSH-------------GPSTLENLTVSLYIPVAYKTPDSTNVKHIVT 824

Human   831 ----------------------NRLSSGGAEMFHVQEMVV------GQEKGNCS--FQKNPTPCI 865
                                  |.|::..| :.|.|..::      .:..||.|  .::||:..:
  Fly   825 SSPKIQSKYAHKIMPINFIDQNNALANNFA-IDHDQSTLLFSATPQHENVGNLSGIVEQNPSISL 888

Human   866 IPQEQENIFHTIFAFFTKSGRKVLDCEKPGIS-CLTAHC---NFSALAKEESRTIDIYMLLNTEI 926
            : .|...:.:|:          ||:|:...:: |:....   |...|..||...:.:...:|.
  Fly   889 L-NEDLPVNNTL----------VLNCQDTNVTLCVPVEIRLENGLQLKPEELMNMTVSFTVNL-- 940

Human   927 LKKDSSSVIQ-FMSRAKVKV----DPALRVVEIAHGNPEEVTVVFEALHNLEPRGYVVGWIIAIS 986
              ||:..:.: |:.:..:||    ||.|....|.  ...|..|:.:       ...:..|.|.:|
  Fly   941 --KDADDIWEYFVIQTDLKVHKIGDPTLSSFTIE--KKIESNVICK-------HAEIAIWKIIVS 994

Human   987 LLVGILIFLLLAVLLWKMGFFRRRYKEII---------------EAEKNRKENEDS 1027
            ::||||:|......|:|.|||:|..|:.:               |.|:|.:...|:
  Fly   995 VIVGILVFSAATYALYKRGFFKRAIKDDLKQLIRDSFEDGIIRTEMEENAQSQGDA 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGA9	NP_002198.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	35..96		13/68 (19%)
		Int_alpha	44..101	CDD:214549	13/58 (22%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	111..174		17/84 (20%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	182..232		12/64 (19%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	233..289		20/63 (32%)
		Int_alpha	244..294	CDD:214549	19/52 (37%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	290..349		24/61 (39%)
		Int_alpha	300..347	CDD:214549	22/49 (45%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	351..408		20/58 (34%)
		Int_alpha	361..414	CDD:214549	20/54 (37%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	411..474		22/65 (34%)
		Int_alpha	425..>466	CDD:214549	19/40 (48%)
		Integrin_alpha2	460..903	CDD:462478	98/504 (19%)
		GFFKR motif	1005..1009		3/3 (100%)
ItgaPS4	NP_611025.2	FG-GAP_3	335..408	CDD:433275	26/74 (35%)
		Int_alpha	384..434	CDD:214549	19/54 (35%)
		Int_alpha	447..>492	CDD:214549	19/44 (43%)
		Integrin_alpha2	486..808	CDD:462478	81/383 (21%)