Protein Alignment ITGA9 and scb

DIOPT Version :10

• Sequence 1: NP_002198.2
• Gene: ITGA9 / 3680
• HGNCID: 6145
• Length: 1035
• Species: Homo sapiens
• Sequence 2: NP_523750.2
• Gene: scb / 36692
• FlyBaseID: FBgn0286785
• Length: 1115
• Species: Drosophila melanogaster
• Alignment Length: 1209
• Identity: 296/1209 - (24%)
• Similarity: 487/1209 - (40%)
• Gaps: 313/1209 - (25%)

Human    16 LLLALVVAGIPAGAYNLDPQRP-----------VHFQGPADSFFGYAVLEHFHDNTRWVLVGAPK 69
            :.|||:.......|:|..| ||           .|......|:|||.::    .....::||||:
  Fly    11 IFLALLALISHIEAFNFMP-RPSRVINSPKHLKFHINQTRSSYFGYTLV----IRQTSIIVGAPR 70

Human    70 ADS--KYSPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDRDD-EWMGVSLAR 131
            |.|  :...::...||:::|.: ||.......|| :||.........|...:|.| :|:|.|:..
  Fly    71 AQSTLESQRTINETGAIYRCSL-TNGVCSPYVLD-SRGNVDAPYSEYTFDSERKDFQWLGGSMDG 133

Human   132 QPKADGRVLACAHRWKNIYYEADHILPHGFCY---------------IIPSNLQAKGRTLIPCYE 181
            ..|...::|.||.|:.......:|:  ||.||               |.|..|::         |
  Fly   134 GTKDTDKLLVCAPRFYAPSSRDNHL--HGVCYWVNNTVASTPQHVTRISPLRLKS---------E 187

Human   182 EYKKKYGEEHGS------------CQAGIAGFFTEELVVMGAPGSFYWAGTI---KVLNLTDN-- 229
            :.|:   |::|:            ..|.:|...|:.|:  ||||...|.|::   :.::..||
  Fly   188 QVKE---EDNGNKASFFYIMGELGLSAHVADDNTKFLI--GAPGINTWRGSVILYRQVDPVDNPT 247

Human   230 ------------TYLKLNDEVIMNRRY---------------TYLGYAVTAGHF--SHPSTIDVV 265
                        ||..::........|               :|.||||::|.|  |:|:.:..|
  Fly   248 ASRRDTSKALRRTYRDVDSNDYTPEHYAPEIPTPGLWGQEEDSYFGYAVSSGFFDSSNPTKLLYV 312

Human   266 GGAPQ-DKGIGKVYIFRADRRSGTLIKIFQASGKKMGSYFGSSLCAVDLNGDGLSDLLVGAPM-- 327
            ..||| :|..|:.|||  |.|..::.|.....|::.|.|||.|:.|.||||||.:|::|.||.
  Fly   313 ATAPQANKQSGEAYIF--DVRGKSIHKYHVFRGEQFGEYFGYSVLAEDLNGDGKTDVIVSAPQHA 375

Human   328 FSEIRDEGQVTVYINRGNGALEEQLALTGDGAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDF 392
            ..:..|.|.:.|:||:|....|.|: |.......|.||.:::.|.|:::||:.|||:|||    |
  Fly   376 LEDSHDNGAIYVFINKGFFNFERQI-LRSPVETMARFGTALSRLGDINHDGYNDVAVGAP----F 435

Human   393 A--GAVYIYHGDAGGIVPQYSMKLSGQKINPV---LRMFGQSISGGIDMDGNGYPDVTVGAFMSD 452
            |  |.|:||.|...|:..|.|.:|......|.   ..|||..:|.|.|:||||:.|..:||..::
  Fly   436 AGNGTVFIYLGSENGLRDQPSQRLDAPSQQPSKYGSHMFGHGLSRGSDIDGNGFNDFAIGAPNAE 500

Human   453 SVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMA 517
            :|.|.||.||:.|.      .::...:.:....|:.|   .:|.|:....... .::.....|..
  Fly   501 AVYLYRAYPVVKVH------ATVKSESREIKPEQEKV---KITACYRLSTTST-DKLVQEQELAI 555

Human   518 DVAKKEKGQMPRVYFVLLGETMGQVTE---KLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAY 579
            .:|..:  |:.||.|     |..|..|   |:...:.|: ||.:...|:...:|:.:||..|..|
  Fly   556 RIAMDK--QLKRVKF-----TQTQTNEISFKVNANFGEQ-CRDFETQVRYSEKDIFTPIDLEMHY 612

Human   580 SLSEHVTGEEE-----RELPPLTPVLRWKKGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSS 639
            .|::.|...||     ..:.|..|        |::.:| .:|...|.::.|.|||||:.|
  Fly   613 ELTKKVPDSEEFCETCAIVDPTEP--------KVSTQN-IIFSTGCATDVCTADLQLRSK----- 663

Human   640 MDEKTLYLALGAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFL 704
             |....|: ||:...:.||..|:|:|:.||....:...:..|.|      .::..:|::::: .:
  Fly   664 -DVSPTYI-LGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAF------AQVPGNCKVVDA-VM 719

Human   705 KCSV--GFPFMRSKSKYEFSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMH 767
            .|.:  |.|..:..:. ..::.||.|.|||:    |.|:.|:..:|...::..||.
  Fly   720 VCDLNRGRPLAKGDTD-SVTISFDVSQLSGQ----SLIIHAEVFSTGYEQNPTDNR--------- 770

Human   768 EVDTSITGIMSPTSFVYGESVDAA-----NFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSI 827
              .|::.|:...|      .:||:     :.|.|:......:.:| ..::.:.|||.:...:||.
  Fly   771 --QTNVIGLKEFT------EIDASGGQTNSQIDLEHYSNSAEIVN-NYEIKSNGPSVIEQLTVSF 826

Human   828 SFPNRLSSGGAEMFHVQEMVVGQEKGNCSF-----------QKNPTPCIIPQE------------ 869
            ..|......|:... :..:.|...|...|:           |.|....:.|.|
  Fly   827 YIPIAYKVAGSTAI-IPIINVTSLKMQASYDSQLLSIDLYDQNNTMLVVDPVEVTTTLSGGLERT 890

Human   870 ------QENIFHTIFAFFTKSGR-----KVLDC----------EKPGISCLTAHCNFSALAKEES 913
                  |....||       ||.     :|||.          ::..:..|||:      .::.:
  Fly   891 VITQNRQSYDIHT-------SGHVHQTMEVLDTSMVATASMSRKRRDLKALTAN------REQYA 942

Human   914 R--TIDIYMLLNTEIL-KKDSSSVIQFMSRAKVKVDPALRVVEIA----HGNPE----------- 960
            |  .:..:.||:.:.. |...:..|.|..|     ||.:.:...|    |..||
  Fly   943 RISNVKAHDLLSDDFKGKLPVNRTIVFNCR-----DPEMTICVRAEMRVHFRPEKSINLNMRYSV 1002

Human   961 ---EVTVV--------------------------FEALHNLEPR--------GYVVGWIIAISLL 988
               ||..:                          |.....:||.        |..: |||.:|::
  Fly  1003 DLNEVNAILVDPWEYFVILTDLKLQKKGDPTSTSFSINRRIEPNIISKHQETGLPI-WIIIVSVI 1066

Human   989 VGILIFLLLAVLLWKMGFFRRRYKEIIE--AEKNRKENE 1025
            .|:|:...::.||:|.|||.|..|:.::  .::|..|.|
  Fly  1067 GGLLLLSAISYLLYKFGFFNRTKKDELDRLVQQNPVEPE 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGA9	NP_002198.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	35..96		18/73 (25%)
		Int_alpha	44..101	CDD:214549	15/58 (26%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	111..174		19/78 (24%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	182..232		16/78 (21%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	233..289		21/73 (29%)
		Int_alpha	244..294	CDD:214549	22/67 (33%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	290..349		24/60 (40%)
		Int_alpha	300..347	CDD:214549	22/48 (46%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	351..408		23/58 (40%)
		Int_alpha	361..414	CDD:214549	23/54 (43%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	411..474		23/65 (35%)
		Int_alpha	425..>466	CDD:214549	19/40 (48%)
		Integrin_alpha2	460..903	CDD:462478	105/501 (21%)
		GFFKR motif	1005..1009		3/3 (100%)
scb	NP_523750.2	Int_alpha	51..103	CDD:214549	15/56 (27%)
		FG-GAP	350..388	CDD:460357	16/37 (43%)
		Int_alpha	409..459	CDD:214549	23/53 (43%)
		Int_alpha	473..>515	CDD:214549	20/47 (43%)
		Integrin_alpha2	509..829	CDD:462478	85/383 (22%)