Protein Alignment ITGA9 and if

DIOPT Version :10

• Sequence 1: NP_002198.2
• Gene: ITGA9 / 3680
• HGNCID: 6145
• Length: 1035
• Species: Homo sapiens
• Sequence 2: NP_523378.2
• Gene: if / 32661
• FlyBaseID: FBgn0001250
• Length: 1396
• Species: Drosophila melanogaster
• Alignment Length: 912
• Identity: 257/912 - (28%)
• Similarity: 442/912 - (48%)
• Gaps: 124/912 - (13%)

Human    18 LALVVAGIPAGAYNLDPQRPVHFQGPADSFFGYAVLEH-----FHDNTRWV--LVGAPKAD-SKY 74
            |.|::..:.|..||:|....|.|:..::|.||:::..|     |:.|...|  :|||||.| |:|
  Fly    20 LILLLIAMSAHGYNIDLPSYVRFRQSSNSMFGFSIAMHKGRSGFYGNQNNVSLIVGAPKFDTSRY 84

Human    75 SPSVKSPGAVFKCRVHTNPDRRCTELDMARGKNRGTSCGKTCREDRDDEWMGVSLARQPKADGRV 139
            ...|...|.||||.:: :.|.:....| ::|.||...  |...:.:..:|:|.::|....:| .|
  Fly    85 QQGVTEAGGVFKCSLN-DDDCKLVPFD-SKGNNRNVD--KEVVDRKSYQWLGATVATGRDSD-LV 144

Human   140 LACAHRWKNIYY-----EADHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKYG-EEHGSCQAGI 198
            :|||.|:  :::     .|..|.|.|.|:  .|:...:...:.||   ....:| ...||||||.
  Fly   145 VACAPRY--VFHTMTPSRAFRIDPVGTCF--TSHNFEEFYEVSPC---RTNNWGYHRQGSCQAGF 202

Human   199 AGFF--TEELVVMGAPGSFYWAG-TIKV--------------------------LNLTDNTYLKL 234
            :...  ....:.:|||||:||.| |..:                          :...:|.....
  Fly   203 SAAINGNGSRLFIGAPGSWYWQGQTYSIPPDAKFPFKPPLYQPFGTGGMASSHDVTRPENQVFST 267

Human   235 NDEVIMNRRYTYLGYAVTAGHFSHPSTIDVVGGAPQDKG-IGKVYIFRADRRSGTLIKIFQASGK 298
            ::...:|.. :||||::..|.|....:.||..|.|:... :|::.:.|     ..:..||..:|:
  Fly   268 SESASVNDD-SYLGYSMVTGDFDGDRSEDVAIGMPRGGNLVGRIVVNR-----WNMANIFNITGR 326

Human   299 KMGSYFGSSLCAVDLNGDGLSDLLVGAPMFSEIRD-EGQV---TVYINRGNGALEEQLALT---G 356
            ::|.|||.||...|::||||.|||:||||:::..: ||:.   .|||....|..||:...|   .
  Fly   327 QIGEYFGYSLATSDVDGDGLDDLLIGAPMYTDPDNVEGKYDVGRVYILLQGGPTEEKRWTTEHIR 391

Human   357 DGAYN-AHFGESIASLDDLDNDGFPDVAIGAPKE-DDFAGAVYIYHGDAGGIVPQYSMKLSGQKI 419
            ||.:: ..||.::.:|.|::.||:.|.|:|||.: .:..|.|||:||...|.:.:.|..:..:::
  Fly   392 DGYHSKGRFGLALTTLGDVNGDGYGDFAVGAPYDGPEGRGVVYIFHGSPMGPLAKPSQIIKSEQL 456

Human   420 ---NPVLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDV-SIFLPGS--INIT 478
               .|..|.||.::|||:|||||.|||:.|||:.||.|.:.::|||..|:. :.|...|  |::.
  Fly   457 VEGAPYPRTFGFALSGGLDMDGNTYPDLAVGAYSSDQVFIFKSRPVAAVNAETSFASNSKLISLD 521

Human   479 APQCH--DGQQPVNCLNVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQMPRVYFVLLGETMGQ 541
            ...|.  ...:.|.|:.:|||:|:.|:::|.::..:...:.| |||...  ||::| |..|....
  Fly   522 DRSCQLVRDHKKVPCMLLTTCWSYTGRYLPEQLDFDVSWLLD-AKKLLN--PRMFF-LRDEGKNI 582

Human   542 VTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEERELPPLTPVLRWKKG- 605
            ..:.::|.|.::.|.:...::..:|||.::|:..||.|:|         |...||.|::|.::.
  Fly   583 RNQTIRLNYGQKYCLNETVYLLDKVQDKLTPLEVEARYNL---------RSSRPLDPMVRHRRSI 638

Human   606 -QKIAQKNQTV-------FERNCRSED-CAADLQLQGKLLLSSMDEKTLYLALGAVKNISLNISI 661
             :.:..:|:.:       .::||..:: |..||    ||.:|::|:   || .|:.:.:.:.:.|
  Fly   639 LEPVIDQNREIVLRDAINIQKNCGPDNICEPDL----KLKVSTVDK---YL-FGSPEPLVIEVFI 695

Human   662 SNLGDDAYDANVSFNVSRELFFINMWQ---KEEMGISCE--LLESDF-LKCSVGFPFMRSK-SKY 719
            ||..:||::|........:|.|..:.|   |::..|:|.  ..|::. |||.:|.|....| :.:
  Fly   696 SNTNEDAFEAAFYMVTPPDLQFRKLQQLGEKKDTPITCSPPTPENNHTLKCDIGNPLESGKIAHF 760

Human   720 EFSVIFDTSHLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPTSFVY 784
            :.|::.:..:  |......|...|.|.|.|:..|.:||.:...|.:..:.|..|.|...|...:|
  Fly   761 KISLVPEEKY--GSSSSYDFYWEANSTNLEKPGSEYDNKIRQSVGIWVDTDLDIKGTSLPDYQLY 823

Human   785 --GESVDAANFIQLDDLECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSSGGAEMFHVQEMV 847
              .:..:..|..:.||:..  |.::| .::.|..||.:..:.|.|..|.....|...|:.:.:..
  Fly   824 KADDYKELENATKEDDIGP--QVVHI-YEIRNNRPSIIEEAEVFIHLPYETIVGDPLMYLLNQPE 885

Human   848 VG 849
            .|
  Fly   886 TG 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGA9	NP_002198.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	35..96		24/68 (35%)
		Int_alpha	44..101	CDD:214549	22/64 (34%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	111..174		16/67 (24%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	182..232		17/79 (22%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	233..289		13/56 (23%)
		Int_alpha	244..294	CDD:214549	13/50 (26%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	290..349		27/62 (44%)
		Int_alpha	300..347	CDD:214549	23/50 (46%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	351..408		21/61 (34%)
		Int_alpha	361..414	CDD:214549	19/54 (35%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	411..474		27/66 (41%)
		Int_alpha	425..>466	CDD:214549	22/40 (55%)
		Integrin_alpha2	460..903	CDD:462478	103/414 (25%)
		GFFKR motif	1005..1009
if	NP_523378.2	Int_alpha	46..110	CDD:214549	22/64 (34%)
		Int_alpha	275..>316	CDD:214549	12/46 (26%)
		Int_alpha	398..451	CDD:214549	19/52 (37%)
		Int_alpha	466..>497	CDD:214549	19/30 (63%)
		Integrin_alpha2	500..892	CDD:462478	103/414 (25%)
		Glutenin_hmw	<1121..1216	CDD:367362