DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITGA9 and ina-1

DIOPT Version :10

Sequence 1:NP_002198.2 Gene:ITGA9 / 3680 HGNCID:6145 Length:1035 Species:Homo sapiens
Sequence 2:NP_499032.1 Gene:ina-1 / 176296 WormBaseID:WBGene00002081 Length:1139 Species:Caenorhabditis elegans


Alignment Length:1153 Identity:282/1153 - (24%)
Similarity:468/1153 - (40%) Gaps:229/1153 - (19%)


- Green bases have known domain annotations that are detailed below.


Human    29 AYNLDPQRPVHFQGPADSFFGYAVLEHFHDNTRWVLVGAPKADSKYSPSVKSPGAVFKCRVHT-- 91
            ::|||...|::..||:.:.|||:|.|||..:...:|:|||:.:|..:.:.:: ||::.|.::|  
 Worm    19 SFNLDVNAPIYRYGPSGTNFGYSVAEHFKGDKPVMLIGAPRGESGQTGTERA-GAMYACDINTFY 82

Human    92 --NPDRRCTEL--------DMARGKNRGTSCGKTCRE-DRDDEWMGVSLARQPKADGRVLACAHR 145
              ..:..|.::        |.|:..|.  :.|:|... .::|:.:..::..:...:|..|.||  
 Worm    83 NGGSNHWCEQVRFEYENVEDYAKRPNE--TRGRTVHPLGKNDQLLASTIVSKGTKNGSALVCA-- 143

Human   146 WKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCYEEY--KKKYGEEHGSCQAGIAGFFTEELVV 208
             ..|.|......|.|.||.:.|||:.:. |...|.::.  ......|:|.|..|.:...|::.:|
 Worm   144 -PLIRYHQTAAYPQGACYELESNLRLQS-TYATCAQKNLPTTDRHNEYGGCMEGFSAAITQDTIV 206

Human   209 MGAPGSFYWAGTI----KVLNLTDNTYLKL-----NDEVIMNR--RYTYLGYAVTAGHF----SH 258
            .|..|:..|.|.:    ...|:.|:...|.     |.::|..|  .:.||||:|..|.|    ..
 Worm   207 TGLIGAVKWTGGVFAKKSSANIFDSVVEKYTMNQPNGDMIRTRLVAHDYLGYSVDIGRFGFWYED 271

Human   259 PSTIDVVGGAPQDKGIGKVYIFRADRRSGTLIKI----FQASGKKMGSYFGSSLCAVDLNGDGLS 319
            ...|.||.||.:....|.|......:.|.:.:.:    |..:|..|||.||.|:..|||||||..
 Worm   272 GKPITVVSGATRYGEHGAVIFLPFIQDSSSKLTLNEDKFIINGTAMGSAFGYSIEVVDLNGDGFD 336

Human   320 DLLVGAPMFSEIRDEGQ----VTVYINRGNGALEEQLALT-------GDGAYNAHFGESIASLDD 373
            ||:||||.......:|.    |.||.::|....:.:..|.       .:..:.:.||.||..|.:
 Worm   337 DLIVGAPFEHRSGIDGNFGGIVYVYFSQGVQRKQHESHLVFHPPKILKNPDFYSQFGLSITKLGN 401

Human   374 LDND--GFPDVAIGAPKEDDFAGAVYIYHGDAGGIVPQYSMK----LSGQKINPV----LRMFGQ 428
            :|.|  ...|.|:|||...|.|||||||.|...  :.::..|    :.|..:..:    :|.||.
 Worm   402 VDGDKSKLNDFAVGAPFAFDGAGAVYIYLGTKN--IEKFRKKPAQVIKGNDLPNLPPGGMRSFGF 464

Human   429 SISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNC-L 492
            |:|||.|||.|||||:.:|:...:.|.|||:||||:::..       :....:..|..:.||| .
 Worm   465 SLSGGSDMDENGYPDLLIGSPSKNFVALLRSRPVISIETK-------HKMEKRMVDIDKGVNCPR 522

Human   493 NVTTCFSFHGKHVPGEIGLNYVLMADVAKKEKGQM----PRVYFVLLGETMGQVTEKLQLTYMEE 553
            ...|||.           |:.|:..|...|...::    ..|:...| |.:....:.....::|.
 Worm   523 GAKTCFP-----------LDMVIYVDEETKRGAELVDFSSDVFMCNL-EAIPFRADTTARGFIEG 575

Human   554 TCRHYV-------AHVKRRV------------QDVISPIVFEAAYSLSEHVTGEEERELPPLTPV 599
            :..|..       :||::|.            :|.|:|:.|....|    :..|::...||    
 Worm   576 SHSHNYSWPCGSNSHVQKRTYRQLIYLPVQESKDWITPLKFRFTVS----IRNEKKPVQPP---- 632

Human   600 LRWKKGQKIAQKNQTVFERNCRSED--------CAADLQLQGKLLLSSMDEKTLYLALGAVKNI- 655
               :..|.:..|:..|..:...|.:        |..|...|..|.|.:..:.....:.|.|.|: 
 Worm   633 ---QGSQLVDLKHYPVLNKYGASYEFDVPFNTLCGEDHTCQTDLSLKAAFKDIPLTSNGYVSNVG 694

Human   656 -----SLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLKCSVGFPFMRS 715
                 .|..::.|..:.||.||.....:.|...:...|..:..|: |.:..:.:...:|.| |..
 Worm   695 EKDYLDLTFTVENKKEKAYQANFYLEYNEEELELPQVQGSKRMIA-ETIGKNIVHLPLGNP-MNG 757

Human   716 KSKYEFSVIFDTS--HLSGEEEVLSFIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMS 778
            .||::|::.|..:  ...|..:.|.|:....|.:.|..|.|.||.....|.::.:.:..|.||..
 Worm   758 ASKHQFTIQFKLTRGRTEGIGKALKFMAHVNSTSQETEEELKDNKWEAEVQIIKKAELEIYGISD 822

Human   779 PTSFVYGESVDAANFIQLDD----LECHFQPINITLQVYNTGPSTLPGSSVSISFPNRLSS---- 835
            |....:|....|.:.::|::    :..|    |.|  :.|.||.|:......||:|.:|.|    
 Worm   823 PDRVFFGGKARAESELELEEDIGTMVRH----NYT--IINHGPWTVRNVEAHISWPYQLRSRFGR 881

Human   836 GGAEMFHVQEMVVGQE--KGNCSFQKNPTPCIIPQE----------------------------- 869
            |...::.:....:..|  .|....:|    |.|.|:                             
 Worm   882 GKNALYLLDVPTITTEFTDGTSEVRK----CFIKQQYEYVNPAEIKLNTKYSTQETAPHRVEHRM 942

Human   870 ------------------QENI-------FHTIFAFFTKSGR----KVLDCEKPGISCLTAHCNF 905
                              :|||       |..:||.....||    |.|.|:....:|.|..|:|
 Worm   943 KREIDEDEEEQSDDLGAVEENIPWFSTANFWNLFAIKGGDGRPREVKHLSCQDNTANCFTVICHF 1007

Human   906 SALAKEESRTIDIYMLLNTEILKKDSSSV--IQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEA 968
            ..:....:..||:...|......:|.|.|  ::..|..|:::|.:..:.:..:.|...|..    
 Worm  1008 DFIDANSAVVIDLRARLWNATFIEDYSDVESVKIRSFGKLQLDESQGIDDDPNNNAAFVET---- 1068

Human   969 LHNLEPRGYVVG-------WIIAISLLVGILIFLLLAVLLWKMGFFRR 1009
              :.:|....:|       ||..|:.::|:||..|:.:.|.|.|||:|
 Worm  1069 --SADPDRPTIGDSRPIPWWIYVIAAVIGVLILSLIIICLSKCGFFKR 1114

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGA9NP_002198.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96 19/64 (30%)
Int_alpha 44..101 CDD:214549 17/68 (25%)
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 111..174 16/63 (25%)
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 182..232 12/55 (22%)
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 233..289 19/66 (29%)
Int_alpha 244..294 CDD:214549 15/57 (26%)
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 290..349 26/66 (39%)
Int_alpha 300..347 CDD:214549 24/50 (48%)
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 351..408 22/65 (34%)
Int_alpha 361..414 CDD:214549 22/58 (38%)
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 411..474 26/70 (37%)
Int_alpha 425..>466 CDD:214549 23/40 (58%)
Integrin_alpha2 460..903 CDD:462478 109/550 (20%)
GFFKR motif 1005..1009 3/3 (100%)
ina-1NP_499032.1 Int_alpha 34..>79 CDD:214549 15/45 (33%)
Int_alpha 317..>362 CDD:214549 22/44 (50%)
Int_alpha 388..434 CDD:214549 21/45 (47%)
Int_alpha 462..>502 CDD:214549 23/39 (59%)
Integrin_alpha2 496..1005 CDD:462478 109/550 (20%)

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