Protein Alignment ITGA9 and pat-2

DIOPT Version :10

• Sequence 1: NP_002198.2
• Gene: ITGA9 / 3680
• HGNCID: 6145
• Length: 1035
• Species: Homo sapiens
• Sequence 2: NP_498948.1
• Gene: pat-2 / 176240
• WormBaseID: WBGene00003929
• Length: 1226
• Species: Caenorhabditis elegans
• Alignment Length: 1272
• Identity: 288/1272 - (22%)
• Similarity: 501/1272 - (39%)
• Gaps: 331/1272 - (26%)

Human     7 PRGAGRLRALLLALVVAGIPAG--AYNLDPQRPV--HFQGPADSFFGYAVLEHFHDNTRW--VLV 65
            ||..|.|..||      |:.||  .:|:|.:..|  |..|   ::|||: |:.:|:....  ::|
 Worm     7 PRRIGLLLGLL------GLLAGVATFNIDTKNVVVHHMAG---NYFGYS-LDFYHEQKGMPVLVV 61

Human    66 GAPKADSKYSPS---VKSPGAVFKCRVHTNPDRRCTE--LDMARG---KNRGTSCGKTCREDRDD 122
            |||:|:|. :|:   ::.||||:.|.|:.   ..|.|  :|..:|   |..|:.....  |::..
 Worm    62 GAPEAESN-NPNLAGIRRPGAVYACSVNR---ATCREVHVDKMKGNLKKLNGSHLVPI--EEKSH 120

Human   123 EWMGVSLARQPKADGRVLACAHRWKNIYYEADHILPHGFCYIIPSNLQAKGRTLIPCYEEYKKKY 187
            ::.|.::....|.| :::.||.::...|.:.:.|.|.|.|:...:... .......|.:| ..::
 Worm   121 QFFGATVRSNDKHD-KIVVCAPKYTYFYSKFEVIEPVGTCFYAENGFD-NAEEFSSCKQE-PARH 182

Human   188 GEE---HGSC--QAGIAGFFTEELVVMGAPGSFYWAGTI---KVLNLTDNTYLKLNDEVIMNRRY 244
            |..   :|.|  .|.:.|...:..|.:||||.:||.|.:   .:.|.||....:..     ::.|
 Worm   183 GRHRLGYGQCGFSAAVPGKKNQNRVFIGAPGVWYWQGAMFSQNIKNQTDRPNTEYG-----SKEY 242

Human   245 TY--LGYAVTAGHFSHPSTIDVVGGAPQDKGI-GKVYIFRADRRSGTLIKIFQASGKKMGSYFGS 306
            .:  :||:...|.|......|:|.|.|:...: ||:.::.:..:  .:|.:......:.|.|.|.
 Worm   243 DHDMMGYSTATGDFDGDGIDDIVAGVPRGNDLHGKLVLYTSKLK--MMINLTDEVSTQHGQYCGG 305

Human   307 SLCAVDLNGDGLSDLLVGAPMFSEI--------------RDEGQVTVYINRGNGALEEQLALTGD 357
            |:...|:|.||..|:::|.|.:::.              .|.|:|.|.:....|...:|:|:.||
 Worm   306 SVAVADVNKDGRDDIIMGCPFYTDYGSVKDAKTQERKPQYDVGKVIVMLQTAPGVFGKQIAVVGD 370

Human   358 GAYNAHFGESIASLDDLDNDGFPDVAIGAPKEDDFA-----GAVYIYHGDAGGIVPQYSMKLSGQ 417
            ..: ..||.::|:..||:.||:.||.:|||    :|     ||||:.||...|:....:.|:.|.
 Worm   371 DQW-GRFGHAVAAAGDLNLDGYNDVIVGAP----YAGKNKQGAVYVIHGSKDGVRELPTQKIEGA 430

Human   418 KI-NPVLRMFGQSISGGIDMDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGS--INITA 479
            .| :..::.||.|::|..|:||||.||:.|||:.|.:..:|..:||:|| .....|.|  |::..
 Worm   431 NIGHGNIKSFGFSLTGNEDVDGNGMPDIAVGAWKSGNAAVLLTKPVVTV-TGQTEPESALISVED 494

Human   480 PQCH-DGQQPVN-CLNVTTCFSFHGK-HVPGEIGLNYVLMADVAKKEKGQMPRVYF--------- 532
            ..|. ||:.... |.::.|||.:.|| ..|.::..:.....|....|    ||.||
 Worm   495 KNCDVDGKLGKQACKHINTCFKYEGKGDTPNDLEFDLRFNLDDHSPE----PRAYFLQKDVKSDR 555

Human   533 ---VLLG----ETMGQVTEKLQLTYMEETCRHYVAHVKRRVQDVISPIVFEAAYSLSEHVTGEEE 590
               |..|    :....:.::::|....:.|..:.......::|.:|||.:...|:..|..||:..
 Worm   556 SIKVAQGSKTRDHPSSIEQRVRLEKGRQKCFRHRFFASSTMKDKLSPIHWSVNYTYVESKTGKLR 620

Human   591 RELPPLTPVLRWKKGQKIAQKNQTVFERNCRSED-CAADLQL-----QGKLLLSSMDEKTLYLAL 649
            .:  .|.|.:  .....::.:|:.....||..:| |..||::     :.|.||.:.|...|
 Worm   621 GD--KLEPAI--DTTVPLSFQNKINIANNCGKDDLCVPDLKVTAVADREKFLLGTQDNTML---- 677

Human   650 GAVKNISLNISISNLGDDAYDANVSFNVSRELFFINMWQKEEMGISCELLESDFLK----CSVGF 710
                   :|:::.|.|:|:|:..:.|:|.         |..|.| ..|.:..|..|    ||...
 Worm   678 -------INVTVQNGGEDSYETKLYFDVP---------QGFEYG-GIESVGGDGSKSAPACSPTS 725

Human   711 PFMRSKSKYEFSVIFDTSHLSGEEEVLSFI--VTA----------------QSGNTERSESLHDN 757
            ....|..|:.|:.  |..:.....:|:|.:  |||                .|.|.|.:.::.||
 Worm   726 DEPDSDGKWTFAC--DLGNPLPANKVVSSVVRVTASSDKPPLAPISINAHVNSSNDEEAHTVADN 788

Human   758 TLVLMVPLMHEVDTSITGIMSPT----SFVYGESVDAANFIQLDDLECHFQPINITLQVYNTGPS 818
            .:...:|:..:...|:.|..:|.    |......|||.:..::..:..|.      .|:.|.|||
 Worm   789 KVTFTIPVDFKNQLSLNGRSNPEQVDFSMTNKTRVDAFDDNEIGPVVSHL------YQISNRGPS 847

Human   819 TLPGSSVSISFPNRLSSGGAEMFHVQEMVVG-QEKGNCSFQK----NP----------------- 861
            .:..:::.|.:|:..:.||..::.:.|.||. ..||.|..::    ||
 Worm   848 EVDSATLDIFWPSFSTEGGHLLYIITEPVVNPPNKGRCRVKQLQNVNPLNLRITNEHVPTEPPVA 912

Human   862 -TPC------------------------------------------------------------- 864
             ||.
 Worm   913 KTPNEYSREEDDESYEDETTTQSQSTRHQSTQHQTHHQSGPVHVYEKDEEKIRQNTGNWQYVEDK 977

Human   865 -------IIPQEQE----NIFHTIFAFFTKSGRK------------------------------- 887
                   .||.:||    :........|.::|.|
 Worm   978 KKKGDYEYIPDDQEYDGDDFEEEDDEDFDRAGSKRVKRNPTPKKKKKGGEHRGEPRSDKARFSDL 1042

Human   888 ------------VLDCEKP---------GISCLTAHCNFSALAKEESRTIDIYMLL--NTEILKK 929
                        |:|.:.|         .:.|....|:...|.::|...::|:..|  ||.:.:|
 Worm  1043 REAVKLSKEAGGVVDYKGPLSRASVDCNSLRCTHIECDIYDLKEDEFVLVEIFSRLYTNTLVDEK 1107

Human   930 DSSSVIQFMSRAKVKVDPALRVVEIAHGNPEEVTVVFEALHNLEPRGYVVG-----WIIAISLLV 989
            :....|..::.|        ||....:..|.:.|::.....|:.......|     |:..:::|:
 Worm  1108 NPGGDISSLALA--------RVTSTKYNLPHKPTLITAVSTNMNAIASEEGRDLPWWLYLLAILI 1164

Human   990 GILIFLLLAVLLWKMGFFRRRY--KEIIEAEKNRKEN 1024
            |:.|.:||.:|||:.|||:|..  .|..|...:|:.|
 Worm  1165 GLAILILLILLLWRCGFFKRNRPPTEHAELRADRQPN 1201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITGA9	NP_002198.2	FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	35..96		21/67 (31%)
		Int_alpha	44..101	CDD:214549	20/63 (32%)
		FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	111..174		11/62 (18%)
		FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	182..232		17/57 (30%)
		FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	233..289		11/58 (19%)
		Int_alpha	244..294	CDD:214549	12/52 (23%)
		FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	290..349		17/72 (24%)
		Int_alpha	300..347	CDD:214549	15/60 (25%)
		FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	351..408		24/61 (39%)
		Int_alpha	361..414	CDD:214549	20/57 (35%)
		FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803	411..474		24/63 (38%)
		Int_alpha	425..>466	CDD:214549	19/40 (48%)
		Integrin_alpha2	460..903	CDD:462478	117/642 (18%)
		GFFKR motif	1005..1009		3/3 (100%)
pat-2	NP_498948.1	Int_alpha	39..98	CDD:214549	21/66 (32%)
		Int_alpha	299..359	CDD:214549	15/59 (25%)
		Int_alpha	372..427	CDD:214549	20/59 (34%)
		Int_alpha	440..>462	CDD:214549	12/21 (57%)
		Integrin_alpha2	474..936	CDD:462478	106/499 (21%)
		Integrin_alpha	1178..1192	CDD:459778	5/13 (38%)