DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITGA9 and itga9

DIOPT Version :10

Sequence 1:NP_002198.2 Gene:ITGA9 / 3680 HGNCID:6145 Length:1035 Species:Homo sapiens
Sequence 2:XP_002940293.3 Gene:itga9 / 100494771 XenbaseID:XB-GENE-994231 Length:1034 Species:Xenopus tropicalis


Alignment Length:537 Identity:107/537 - (19%)
Similarity:179/537 - (33%) Gaps:180/537 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   642 GSELRAVFPEGPWEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMAWLGVIQKA 706
            |.:|:....||.   .|....:|:||.:.|:::...|.||       ..|:          :||:
 Frog   141 GQDLQEQLAEGC---RLTQHLVQKLSPENDNDDDEDVQVE-------VAEK----------VQKS 185

Human   707 AASLGDTLSEQQLGDSDIPVIVYRCVDYITQCGLT---SEGIYRKCGQTSKTQRLLDSLRQDARS 768
            :|    ....|:..:.::|      .|.:.:|.:|   |.|.|             || .|..:.
 Frog   186 SA----PREMQKAEEKEVP------EDSLEECAITCSNSHGPY-------------DS-NQPHKK 226

Human   769 VHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLAWLEA--------SEIEDEEEK-------- 817
            ..:...|..||..              |...:..:.|.:|        |:.|:||||        
 Frog   227 TKITFEEDKVDST--------------LIGSSSHVEWEDAVHIIPENESDDEEEEEKGPVSPRNL 277

Human   818 -ISRYREL----------LVHLPPVNRATVKALISHLYCVQ----CFSDTNQMNTHNLAIVFGPT 867
             .|...|:          .:.:||...|:.::..|..:.::    |           :|:..|..
 Frog   278 QESEEEEVPQESWDEGYSTLSIPPEMLASYQSYSSTFHSLEEQQVC-----------MAVDIGRH 331

Human   868 LF---QTDGQDYKAGKVVEDLINHYVVVFSVDEEELRKQREEVTAIVKMRVAGTASGTQHAGDFI 929
            .:   :.:.|:....::..:|:         ||:|     .||......|...|.||.....| .
 Frog   332 RWDQVKKEDQEATGPRLSRELL---------DEKE-----PEVLQDSLDRCYSTPSGCLELTD-S 381

Human   930 CTVY------LEEKKV---------ETEQHVKIPASMTAEELTLEILDRRNVSIREKDYWTCF-- 977
            |..|      ||:::|         |..|.|:.....:...|:.|:||.:...:.:.....|:  
 Frog   382 CQPYRSAFYVLEQQRVGLAIDMDEIEKYQEVEEDQDPSCPRLSRELLDEKEPEVLQDSLDRCYST 446

Human   978 --EVNEKEEAERPLHFA-----EKVLPIVHGLGIDSHLVVKKYQSMEAMLLYLASRVGDTKHGMM 1035
              :..|..:..:|...|     |:.|    ||.:|...:.|..:..|             ..|..
 Frog   447 PSDYLELPDLGQPYSSAVYSLEEQYL----GLALDVDRIKKDQEEEE-------------DQGPP 494

Human  1036 KFREDRSLLGLGLPS--GGFHDRYFILNSSCLRLYKEVRSHRPEKEWPVKSLKVYLGVKKKLRPP 1098
            ..|..|.||.:..|.  ....||.:...||||        .:|:...|..| ..|...:|.:   
 Frog   495 CPRLSRELLEVVEPEVLQDSLDRCYSTPSSCL--------EQPDSCQPYGS-SFYALEEKHV--- 547

Human  1099 TCWGFTV-VHETEKHEK 1114
               ||:: |.|.||..|
 Frog   548 ---GFSLDVGEIEKKGK 561

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITGA9NP_002198.2 FG-GAP 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 35..96
Int_alpha 44..101 CDD:214549
FG-GAP 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 111..174
FG-GAP 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 182..232
FG-GAP 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 233..289
Int_alpha 244..294 CDD:214549
FG-GAP 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 290..349
Int_alpha 300..347 CDD:214549
FG-GAP 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 351..408
Int_alpha 361..414 CDD:214549
FG-GAP 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00803 411..474
Int_alpha 425..>466 CDD:214549
Integrin_alpha2 460..903 CDD:462478 53/297 (18%)
GFFKR motif 1005..1009 1/3 (33%)
itga9XP_002940293.3 Int_alpha 43..91 CDD:214549
Int_alpha 243..>280 CDD:214549 8/36 (22%)
Int_alpha 300..345 CDD:214549 8/55 (15%)
Int_alpha 360..413 CDD:214549 13/53 (25%)
Int_alpha 424..>465 CDD:214549 7/40 (18%)
Integrin_alpha2 459..902 CDD:462478 33/135 (24%)
Blue background indicates that the domain is not in the aligned region.

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