DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG15706 and MFSD6

DIOPT Version :10

Sequence 1:NP_611099.2 Gene:CG15706 / 36799 FlyBaseID:FBgn0034093 Length:539 Species:Drosophila melanogaster
Sequence 2:NP_060164.3 Gene:MFSD6 / 54842 HGNCID:24711 Length:791 Species:Homo sapiens


Alignment Length:610 Identity:130/610 - (21%)
Similarity:257/610 - (42%) Gaps:110/610 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 VRLNRRLLPIKAHFFFFMAAMGPILPQLSVIGKQIGVPPDVMGYITAALPLLYVLAKPLVGFLAD 66
            |::|..||..|..:|||.:|.|.:.|.|.|..||:|:.|...|.:......:...:.|..|.:||
Human    62 VKINNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPSQSGLLVGIRYFIEFCSAPFWGVVAD 126

  Fly    67 YFTSLRKFIFISLILIMTLAFAGFYFL-PDNSHFIPLDEGSAQWNVTLLTNPNDCN---TIIQSS 127
            .|.. .|.:.:..:|...|...|..|: |.....:|        .:...|:|.:.:   ||:.::
Human   127 RFKK-GKIVLLFSLLCWVLFNLGIGFVKPATLRCVP--------KIRPTTHPTNASHQLTILPTN 182

  Fly   128 NAFCQTTHQAKCIQEEKEVGEFSALIVANESGL----NLN-------QNLLHGNESYHICL---- 177
            ::|......:..::|::.:.| :.|.|::...|    |:|       |.....|....:.|    
Human   183 SSFTSFLTISPKMREKRNLLE-TRLNVSDTVTLPTAPNMNSEPTLQPQTGEITNRMMDLTLNSST 246

  Fly   178 ---TQPAAIDWNSASCEVRHVNS-------CIYGAGKF-WLFVCLLCIGIVG--FNVTN-SISDA 228
               ..|.::...:.:..|....|       .:|...:. .:|:.:|.:.|:|  |:.:: :|.|.
Human   247 ATPVSPGSVTKETTTVIVTTTKSLPSDQVMLVYDQQEVEAIFLVILVVVIIGEFFSASSVTIVDT 311

  Fly   229 CCFDLLGDEEQEKYGAQRVWGTIGFGATAMLAGIVVNWWTTDAV---KSLTPA-----LIIMCVF 285
            .....|| :.:::||.||:||::|:|...:..||.:::...:.:   |...|.     .|:..||
Human   312 VTLQYLG-KHRDRYGLQRMWGSLGWGLAMLSVGIGIDYTHIEVLIDGKGCKPPEYRNYQIVFIVF 375

  Fly   286 SLLDLFSV--------------------SKLKLPKLGGSESIWS--------------DVWQLVR 316
            .:|...::                    .::::|::..:.|..|              :.|.|::
Human   376 GVLMTMALIVATQFRFRYNHFKNDDSKGKEVEIPQVERNNSTESSEETPTTTSHSQAFNFWDLIK 440

  Fly   317 KPPILVF---LFFATMAGIIDSFIIYFMFWHLEQVAEATGYMHQIKLIEGLVVAAECLAGEVPFF 378
            ....:.:   ||.|...|....|:..|::||||.:...|.......::..:        .|:..:
Human   441 LLCSVQYGSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHV--------SELTAY 497

  Fly   379 FYSGKIIKKLGYVHCMSMCFFFYAVRLSLIAWIPNPWYLVGVELFFQGITYALCYTCIVAYASAV 443
            |:|.|:|:.:|::..:.:.......|...|:::.|.|.::.:|: .||:|:|..:...::|.||.
Human   498 FFSHKLIELIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEV-LQGVTHAAIWAACISYLSAA 561

  Fly   444 APPGTSATVQGLMAGMDDGLGFSIGSLIGGLMFKSLGGRESFKYFAIAAICTCVAHIVIRPTSRK 508
            .||....:.||::.|:..|||...|::|||::....|...:|:...:|.:...:...:|      
Human   562 VPPELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALI------ 620

  Fly   509 RQFLPRQGYVPPTEQEIKQPPAQEM 533
                  |....|.|:|.|...|:.:
Human   621 ------QWLAVPDEEEDKTMLAERI 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG15706NP_611099.2 MFS_MFSD6 10..503 CDD:340893 119/570 (21%)
MFSD6NP_060164.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 22..47
MFS_MFSD6 70..622 CDD:340893 120/583 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 407..427 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..687
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 723..791
Blue background indicates that the domain is not in the aligned region.

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