DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mrj and DNAJB12

DIOPT Version :9

Sequence 1:	NP_001246364.1	Gene:	mrj / 36797	FlyBaseID:	FBgn0034091	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001352009.1	Gene:	DNAJB12 / 54788	HGNCID:	14891	Length:	377	Species:	Homo sapiens

Alignment Length:	167	Identity:	55/167 - (32%)
Similarity:	79/167 - (47%)	Gaps:	39/167 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DYYKILDVSRSATDSEVKKAYRKLALKWHPDKNPDNLDEANKRFRELSEAYEVLSDARKRRIYDA 67
            |||:||.|||.|:|.::|||||:||||:|||||  :...|.:.|:.:..||.|||:..||:.||
Human   110 DYYEILGVSRGASDEDLKKAYRRLALKFHPDKN--HAPGATEAFKAIGTAYAVLSNPEKRKQYD- 171

  Fly    68 RATLHKSSNSGSSSSNSSSYTRYRNGGTGGSSSYGRDYDYDYYP--------GSGYGSGSGRRSG 124
                    ..|...|.::     |:|  .|...:.|.::.|..|        |.|:.|.:.....
Human   172 --------QFGDDKSQAA-----RHG--HGHGDFHRGFEADISPEDLFNMFFGGGFPSSNVHVYS 221

  Fly   125 NRYQAFTFRNIFEGTPFHKMFEKKRRIYDEYGKDGLG 161
            |....:|::.           .:.||  |..|..|||
Human   222 NGRMRYTYQQ-----------RQDRR--DNQGDGGLG 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mrj	NP_001246364.1	DnaJ	2..>66	CDD:223560	33/62 (53%)
mrj	NP_001246364.1	DnaJ	3..66	CDD:278647	33/62 (53%)
DNAJB12	NP_001352009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..92
		DnaJ	110..>236	CDD:333066	48/154 (31%)
		DUF1977	268..368	CDD:312722
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810