DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG44243 and AIM22

DIOPT Version :9

Sequence 1:	NP_001188958.1	Gene:	CG44243 / 36795	FlyBaseID:	FBgn0265178	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_012489.2	Gene:	AIM22 / 853401	SGDID:	S000003582	Length:	409	Species:	Saccharomyces cerevisiae

Alignment Length:	366	Identity:	101/366 - (27%)
Similarity:	173/366 - (47%)	Gaps:	79/366 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 TRLASSGVEPPSAGQQEI--------KKQRRQPPPVVPDSEIK-----KSVFISQ--SSDVFTNL 72
            |..|||..|..||..:::        .||      ::..|:::     |..|:.|  |:..:.||
Yeast    72 TTKASSMEEDISAFNKDLYNFYNIGYAKQ------IMSASQLENIVKAKGRFVIQSLSTSPYYNL 130

  Fly    73 ALEDWLYKNFDFSRHHV----LLLWANDPCVVIGRHQNPFTEANVSQLVERGITLARRNSGGGAV 133
            |||::::||...::...    ||.:.||.|.|||::||.:.|.::::|..:...|.||.||||.|
Yeast   131 ALENYVFKNTPRAKRGPDNCRLLFYINDRCAVIGKNQNLWQEVDLAKLKSKNFELLRRFSGGGTV 195

  Fly   134 YHDLGNLNCTFFSPRERYDRK-YNLNIVTRALFREW------AIKAEINERDDIVVMNKKISGTA 191
            .|||||:|.::.:.||:::.| :|..|:      :|      .::.::|||.||:....||||:|
Yeast   196 LHDLGNVNYSYLTSREKFETKFFNKMII------KWLNSLNPELRLDLNERGDIIQDGFKISGSA 254

  Fly   192 AKLGHPNSYHHCTILASANKLHLGESLVREPA-----NYISKATASVPSPIRN--LVDVNRTVNV 249
            .|:....:|||.|:|.:|:.......|  ||:     .:.|....||.|.|:|  ::..|:.:.|
Yeast   255 YKIAGGKAYHHATMLLNADLEQFSGLL--EPSLPNNMEWESSGVHSVKSKIKNVGIITPNQFIAV 317

  Fly   250 AQLRSAVGYEYLRTAATTLEDGGSTQTMQQRGFQLVNPTEKWFPGIEELRSNYSSWDWVIGKTPK 314
            ...|          ...|.:..|.........|:.:|..      |::..:...|..|.....||
Yeast   318 VSER----------FQKTFKVDGEIPIYYCDEFKSINDE------IKDAMNTLQSEQWKYFSGPK 366

  Fly   315 FTVQKELEVKGDEQDMKLKLSVEVEAGLMKE------IGIQ 349
            |:|  :::.||        |:::||.|::.:      ||::
Yeast   367 FSV--KIKDKG--------LTIKVEKGMIYDCDRNDLIGLE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44243	NP_001188958.1	LplA	63..311	CDD:223173	77/267 (29%)
CG44243	NP_001188958.1	lipoyltrans	60..380	CDD:161920	90/316 (28%)
AIM22	NP_012489.2	BPL_LplA_LipB	117..409	CDD:417464	90/315 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343852
Domainoid	1	1.000	107	1.000	Domainoid score	I1434
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	108	1.000	Inparanoid score	I1401
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54427
OrthoFinder	1	1.000	-	-		FOG0003725
OrthoInspector	1	1.000	-	-		oto99132
orthoMCL	1	0.900	-	-		OOG6_101366
Panther	1	1.100	-	-	LDO	PTHR12561
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R663
SonicParanoid	1	1.000	-	-		X3085
TreeFam	0	0.000	Not matched by this tool.
	12	11.930