Protein Alignment caly and BAP1

DIOPT Version :10

• Sequence 1: NP_611096.1
• Gene: caly / 36794
• FlyBaseID: FBgn0262166
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: XP_011532451.1
• Gene: BAP1 / 8314
• HGNCID: 950
• Length: 752
• Species: Homo sapiens
• Alignment Length: 791
• Identity: 223/791 - (28%)
• Similarity: 292/791 - (36%)
• Gaps: 406/791 - (51%)

  Fly    45 GWLELESDPGLFTLLLKDFGCHDVQVEEVYDLQKPIESP-YGFIFLFRWIEERRARRKIVETTAE 108
            |||||||||||||||::|||...|||||:||||...:.| |||||||:||||||:|||:.....:
Human     4 GWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDD 68

  Fly   109 IFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGDTLSRLKTHTKGMSPENKGLAI 173
            ..|.|::.::::|||.|::||||||||||||||||  :::.||.||||:|..|||.|||:||.||
Human    69 TSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNC--SSVDLGPTLSRMKDFTKGFSPESKGYAI 131

  Fly   174 GNTPELACAHNSHAMPQARRRLERTGAGVSSCRFTGEAFHFVSFVPINGQLFELDGLKPYPMNHG 238
            ||.||||.||||||.|:.|...|:.. |:|:.| |.|||||||:|||.|:||||||||.||::||
Human   132 GNAPELAKAHNSHARPEPRHLPEKQN-GLSAVR-TMEAFHFVSYVPITGRLFELDGLKVYPIDHG 194

  Fly   239 GWEDSEDWTDKFRRVMAERLGIAT-GE--QDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTL 300
            .|.:.|:||||.|||:.||:|:|| ||  .|||||||||||||||....:|.:|:.|:..|...|
Human   195 PWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYEARLHVLKVNRQTVLEAL 259

  Fly   301 QKLLKA----------------------------------------------------------- 306
            |:|::.
Human   260 QQLIRVTQPELIQTHKSQESQLPEESKSASNKSPLVLEANRAPAASEGNHTDGAEEAAGSCAQAP 324

  Fly   307 ----------------------------------------------------------------- 306
                                                                             
Human   325 SHSPPNKPKLVVKPPGSSLNGVHPNPTPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVR 389

  Fly   307 --------------DEQGE---------------------SGNGDSQ------------------ 318
                          ||:.:                     ||:.|.|
Human   390 PPQQYSDDEDDYEDDEEDDVQNTNSALRYKGKGTGKPGALSGSADGQLSVLQPNTINVLAEKLKE 454

  Fly   319 ---------------------------------------------------------------RP 320
                                                                           ||
Human   455 SQKDLSIPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRP 519

  Fly   321 DTPTT--------------------------------------------LLEPSAFTA------- 334
            .:|.|                                            :|.|.|.|.
Human   520 SSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSP 584

  Fly   335 ----------------------------------------------------------------- 334
                                                                             
Human   585 SIRPIQGSQGSSSPVEKEVVEATDSREKTGMVRPGEPLSGEKYSPKLPIARGALLLARPDQRCNA 649

  Fly   335 ---RDLQSLLKNLDTEIAINEQHLADENDRRHMFKVDASRRTHNYDKFICTFLSMLAHQGVLGEL 396
               ::|.:|||.::.|||..|..|.:|.::|..||:|..|||||||:|||||:||||.:|:|..|
Human   650 GFWQELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANL 714

  Fly   397 VSQHLLPSKKVSGQGAA-NRISKQSTTASAGGSTAAGTASTPKTQQQQAAAAKNGKSPSKTPGRR 460
            |.|::...::   ||.: .|:.||                                   :.|.||
Human   715 VEQNISVRRR---QGVSIGRLHKQ-----------------------------------RKPDRR 741

  Fly   461 RKGRNKCRKRK 471
            ::.|....||:
Human   742 KRSRPYKAKRQ 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
caly	NP_611096.1	Peptidase_C12_UCH37_BAP1	46..274	CDD:187738	147/231 (64%)
		UCH_C	348..393	CDD:465622	26/44 (59%)
BAP1	XP_011532451.1	Peptidase_C12_UCH37_BAP1	5..233	CDD:187738	147/231 (64%)
		UCH_C	666..711	CDD:465622	26/44 (59%)