DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment calypso and bap1

DIOPT Version :9

Sequence 1:	NP_611096.1	Gene:	calypso / 36794	FlyBaseID:	FBgn0262166	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001008206.1	Gene:	bap1 / 493568	XenbaseID:	XB-GENE-494978	Length:	685	Species:	Xenopus tropicalis

Alignment Length:	724	Identity:	220/724 - (30%)
Similarity:	290/724 - (40%)	Gaps:	339/724 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GWLELESDPGLFTLLLKDFGCHDVQVEEVYDLQKPIESP-YGFIFLFRWIEERRARRKIVETTAE 108
            |||||||||||||||::|||...|||||:||||.....| |||||||:||||||:|||:.....:
Frog     4 GWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCPGPVYGFIFLFKWIEERRSRRKVSTLLDD 68

  Fly   109 IFVKDEEAISSIFFAQQVVPNSCATHALLSVLLNCNENNLQLGDTLSRLKTHTKGMSPENKGLAI 173
            ..|.::|.::::|||.|::||||||||||||||||  :.:.||.||||:|..|||.|||:||.||
Frog    69 TSVMEDEVVNNMFFAHQLIPNSCATHALLSVLLNC--SGVHLGPTLSRIKEFTKGFSPESKGYAI 131

  Fly   174 GNTPELACAHNSHAMPQARRRLERTGAGVSSCRFTGEAFHFVSFVPINGQLFELDGLKPYPMNHG 238
            ||.||||.||||||.|:.|...|:.. |:|:.| |.|||||||:|||.|:||||||||.||::||
Frog   132 GNAPELAKAHNSHARPEPRHLPEKQN-GISAVR-TMEAFHFVSYVPIKGRLFELDGLKVYPIDHG 194

  Fly   239 GWEDSEDWTDKFRRVMAERLGIAT-GE--QDIRFNLMAVVPDRRIAITHKLKMLRTNQAIVSGTL 300
            .|.:.|:||||.|||:.||:|:|| ||  .||||||||||||||:....||.:|:.|:..|...|
Frog   195 PWAEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRLKYESKLHILKMNRQTVLEAL 259

  Fly   301 QKLLKADE----------QGES------------------------------------------- 312
            |:|::..:          :|:|
Frog   260 QQLIRVTQPELIQAQKPTEGQSTEETKSAALKAPVSQESHRAHHGSHRNATDVGAEPPGALIRGP 324

  Fly   313 -----------------------------------------------GNGDSQ------------ 318
                                                           |.|.|:
Frog   325 VMSAYSKPNSLAQNGGTVAAPASRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRGVPPPAPDTDEE 389

  Fly   319 ----------------------------------------------------------------- 318

Frog   390 EEEETENVRRPLTPPGFKRRSSEPLPPPPGPEPGVLAEKLKETQRDLCSPLSIKTGAPTAPHSQP 454

  Fly   319 ---------------------------------RPDTPTTL------------------------ 326
                                             ||.:|.||
Frog   455 SPTPSNESTDTASEIGSAFNSPLRSPLRSANPTRPSSPVTLHLSKVLFGEEEPLLRLDCVRYNRA 519

  Fly   327 ---------------------------------------------LEPSA-------------FT 333
                                                         .||..             |:
Frog   520 VRELGPHISTGILHLSKDGYLCPLSRLETGKVSPKGNKVEEPRESSEPDTERSRVTEVPQGEKFS 584

  Fly   334 ARDLQSLLKNLDTEIAINEQHLADENDRRHMFKVDASRRTHNYDKFICTFLSMLAHQGVLGELVS 398
            .::|.:|||.::.||:.:|..|.:|.::|..||:|..|||||||:|||.|:||||.:|:|..||.
Frog   585 PKELLALLKCVEAEISSSEACLREELEKRKKFKIDDQRRTHNYDEFICAFISMLAQEGMLASLVE 649

  Fly   399 QHLLPSKKVSGQGAA-NRISKQSTTASAGGSTAAGTASTPKTQQQQAAAAKNGKSPSKTPGRRRK 462
            |::...::   ||.: .|:.||                                   :.|.||::
Frog   650 QNISVRRR---QGVSIGRLHKQ-----------------------------------RKPDRRKR 676

  Fly   463 GRNKCRKRK 471
            .|....||:
Frog   677 SRPYKAKRQ 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
calypso	NP_611096.1	Peptidase_C12_UCH37_BAP1	46..274	CDD:187738	147/231 (64%)
bap1	NP_001008206.1	Peptidase_C12_UCH37_BAP1	5..233	CDD:187738	147/231 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..325		2/51 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..425		3/61 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..493		2/52 (4%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..579		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..685		9/60 (15%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q92560	673..678		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	270	1.000	Domainoid score	I1801
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3421
Inparanoid	1	1.050	397	1.000	Inparanoid score	I1900
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1363547at2759
OrthoFinder	1	1.000	-	-		FOG0006969
OrthoInspector	1	1.000	-	-		otm49008
Panther	1	1.100	-	-	LDO	PTHR10589
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4495
SonicParanoid	1	1.000	-	-		X5060
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100