DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and CLU1

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	NP_013725.1	Gene:	CLU1 / 855025	SGDID:	S000004614	Length:	1277	Species:	Saccharomyces cerevisiae

Alignment Length:	1486	Identity:	330/1486 - (22%)
Similarity:	572/1486 - (38%)	Gaps:	409/1486 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 KPTVVDAVEDNADTNA-NVEKPQEGGAPDAEADGDDIDLDALQDIGITVNISSPGADLLCVQLSS 159
            |.||....|||...|. :::|.|       .:..:||..    :||               :.|.
Yeast    14 KVTVKLPKEDNHSHNTKHLKKTQ-------SSKNNDISF----EIG---------------KESK 52

  Fly   160 MELVQEIHQLLMDREETCHRTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIH 224
            ::.|.::..::...:...:....:::.|:...|..: :|.|...:....::::.:||:.|||..|
Yeast    53 IQTVLDVLAMIPSSKYLTNVGLKTIEGDSQLSDEMS-IKEIVGEKSELKLQLILKPYSAREALKH 116

  Fly   225 VRHVRDLLK-NLDPADAYNGIDCTSLTYLNTITQGDLLD--KKRTRPDSVDCTPPEYVTPGVSDP 286
            |..|||.:. ..:.:|..:....::.:..:::..|.:.:  |:..:.:..|....:.....|:|.
Yeast   117 VITVRDFIGFAQETSDGLSEFAISTGSSFSSLPLGPIKERSKQEEKDEKSDPEEKKNTFKDVTDE 181

  Fly   287 PILP----LHPNVKNAKGPQALKVLTTSA--------------WNPPPGPRKLHGDLMYLYVVTM 333
            ..|.    :|....:.|.....|:||:.:              :||.|...:..|.|.||.:||:
Yeast   182 EKLKFNEMVHEVFSSFKNSSINKLLTSESNIITPCVRSLSFAPYNPVPPFYRSKGHLFYLQIVTL 246

  Fly   334 EDKRFHISACSKGFFINQSTDDTFNPKP----DNPSHLS---HSLIDLLSHISPSFRRAFQTIQK 391
            |.:.|:|:|...||::|:|....|:|.|    |..:|.|   :||.||::..|..|....|..:|
Yeast   247 EGESFYITAIPSGFYVNKSNSTKFDPSPKENTDENAHSSLIYYSLFDLIASRSKKFISHVQAFEK 311

  Fly   392 RRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIPG--------QT----- 443
            :.:   |.:  :|.|                :|..:.|..|..:...:|.        ||
Yeast   312 KLS---ALD--STSY----------------VRPSNTFLHKPWFVSSLPPNNPDYLRLQTAALDT 355

  Fly   444 ---RDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKM 505
               |::|:|.|..::|...||.:|:..||...||..:|...|..|||::...:.:|:||...|:.
Yeast   356 TPERNFNDEFQAIKDLTTSTLQDRIEMERLFSKVVHEFSVTAASGAMSIFYSDFVAMNPESPTRD 420

  Fly   506 QMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYR 570
            |:|:.:|||:|...||..:|:..|||.||..|...||..:.:.|.:.:..:..|.|.||::.|.|
Yeast   421 QIFLKDNIFYSYVSDVSGNYEGKGGDEAAIAASNQDLKTINILNRLHMHEVRYLLTTVVEFAGRR 485

  Fly   571 VTAQSIIPGIL--------------EREQEQ-----SVVYGSID--FGKTV-------LSHPKYL 607
            :.||:.:||:|              |...|.     :|.|| :|  .||.|       :...|::
Yeast   486 ILAQTPVPGLLATMGNKIVKDANTGEEVTEDFVNDINVKYG-LDEGLGKIVYDADFDSVLEKKFV 549

  Fly   608 ELLRQAGKHLKILPHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQ 672
            :..     |||  .|.|     ...||..|.:.|||:|.|.|.|||||..|:|.|:||.:    |
Yeast   550 KAF-----HLK--KHKV-----NGTELAFSSQSKGIVGFDKRRYILDLANTYPLDINFAR----Q 598

  Fly   673 LSKELVDMGFPIEHRHKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPAL 737
            ....:.:.|....||..|  ||.||:|.:..::                    .||
Yeast   599 NFDNIEETGNRYPHRQTL--LRPELVEKWWNNK--------------------VEK--------- 632

  Fly   738 EGAEAASKVNGAEKPDDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSNEVQAAEVVK 802
            ||.|.             ||..||                          |:
Yeast   633 EGVEF-------------EKAYEE--------------------------NL------------- 645

  Fly   803 RACAAVGSLKEKEFDFRFNPDVFS-PGIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEH 866
                           |.:|||.:. .||..|:             |.|.:.:|..:.||:.|:::
Yeast   646 ---------------FSYNPDAYQVEGIEDAN-------------VDEMSNYLQKEVIPSVIQDY 682

  Fly   867 MS-HSSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMPRMDYLHRIAVLELIVRATKHIYY--- 927
            :| :.|:|.:|:.|.::||.:|||:|||||:|::..:......:|....|:.:.:..|.  |
Yeast   683 LSGNLSTPYNGEHLADTLHKNGINMRYLGKIIELSQKELDSQIVHYEQNLKAVEQDNKE--YEDW 745

  Fly   928 --TYMQNTEPLHLSAAISHFLNCLLTNGPVNPAVSSE------EAHKKRGNG------------- 971
              :|:|..|.:.......  :|.|:..|...|...:|      |..||..:|
Yeast   746 EKSYLQKIENMIKERQAK--INKLVQEGKEVPKELTEDLKLNDEEIKKPTDGKPVVVAYDELVPL 808

  Fly   972 ---------GKHNKHKSSKGGK-----------GQQQQQTTG-NQNGSSSGSS-------NSSSA 1008
                     .:..||......|           ........| |.|.......       |..|
Yeast   809 IKISELEIVSRSLKHVLKDLSKDVPVFLVPSLVAYVFNMLVGINYNADPKPEPVDEFYPVNKCS- 872

  Fly  1009 SDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNF 1073
              :..:|...|.:.:.|:|.:.:..:|..:.||..:..    ..:|:|:...|.|||:|.:||.|
Yeast   873 --FAKLTRSELLEAVSKQAFLRFRHQLPSNWIEAYMEN----PFTLIRSVSYKFGIQLLNKEYFF 931

  Fly  1074 ---------ESKHK----------PTFGDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLF 1119
                     :|..|          .||...|: .:.|.||.....::.:..|:..|.:.|.:..
Yeast   932 TREQLESYKQSLDKKIRNKFVEPPTTFSLSDL-TIIPRVKFSEYTSSVSEEFWAQGASMINEDK- 994

  Fly  1120 KEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHP 1184
            :....|::.::.:|.:|...||.........|:.:...|....:|:|..::|..:.|||:|:|..
Yeast   995 QSALTLLAQSITVLEDVNNILHPAVAEKYLSLSAIYNKLALYPEAIAFCRKACTIYERVSGIDSF 1059

  Fly  1185 STILEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGE----DHPEVALIDSNISLILHALGEY 1245
            ..:...|:|::..|:| ....:..::|. |...:|...|    .||....|.:::..:  |||..
Yeast  1060 EMMRALTNLAILEFSN-ESPYNATVVYN-RLAEILKVYELPKIHHPAPTSIFNHLEQL--ALGVQ 1120

  Fly  1246 ELSLRFIEHALKLNLKYFGDKDMHV-------ALSYHLMARTQSCMG-------DFRSALNNEKE 1296
            :         .||.::..|....:|       :|:|   ..|:|.:|       ||..||.:...
Yeast  1121 D---------TKLAIEVLGQLSSYVVELEGKDSLAY---GYTESRLGNLFAALKDFHRALEHITV 1173

  Fly  1297 TYSFYKSQLGENHEKTRDSAECLRLLT-------QQAVLLQRKMNDIYSSG---KLTS------D 1345
            |...:..|||.||..:..|.:.:..|:       |:..|.|.:|:...|:.   |.|:      |
Yeast  1174 TQGIFTKQLGMNHTHSAQSRQWVNGLSSLIMDLKQKKQLAQDQMSTTGSNSAGHKKTNHRQKKDD 1238

  Fly  1346 LPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFKTDSTENEVND 1401
            :.|                        :::.|.:.::.:.||.......::|:.|:
Yeast  1239 VKP------------------------ELANKSVDELLTFIEGDSSNSKSKNKTNN 1270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	15/72 (21%)
		DUF727	<324..387	CDD:283065	25/69 (36%)
		CLU	445..665	CDD:289977	81/247 (33%)
		eIF3_p135	872..1073	CDD:289571	54/252 (21%)
		TPR_12	1098..1177	CDD:290160	13/78 (17%)
		TPR_10	1146..1184	CDD:290111	10/37 (27%)
		TPR_12	1183..1261	CDD:290160	16/81 (20%)
		TPR repeat	1190..1215	CDD:276809	5/24 (21%)
		TPR_12	1225..1303	CDD:290160	20/91 (22%)
		TPR repeat	1228..1258	CDD:276809	4/29 (14%)
CLU1	NP_013725.1	CLU_N	49..124	CDD:405693	16/75 (21%)
		CLU	360..595	CDD:404173	81/247 (33%)
		CLU-central	690..931	CDD:271318	54/251 (22%)
		TPR_12	1019..>1071	CDD:315987	12/51 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344258
Domainoid	1	1.000	116	1.000	Domainoid score	I1314
eggNOG	1	0.900	-	-		E1_KOG1839
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I583
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54861
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	1	1.000	-	-		oto99310
orthoMCL	1	0.900	-	-		OOG6_102505
Panther	1	1.100	-	-	LDO	PTHR12601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R213
SonicParanoid	1	1.000	-	-		X1595
TreeFam	1	0.960	-	-
	14	13.790