DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and cluh

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	XP_012812739.1	Gene:	cluh / 780032	XenbaseID:	XB-GENE-5874446	Length:	1550	Species:	Xenopus tropicalis

Alignment Length:	1407	Identity:	745/1407 - (52%)
Similarity:	1002/1407 - (71%)	Gaps:	97/1407 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NQQNSNQNLVNGNGTA---------ADGPAAKKKGKKNRNKSPTEPTTEAVLSNGHAEKPTVVDA 102
            ::||:|..::....|.         |:..:|.||......:...:.:|...|.||
Frog   206 DKQNANFVILKSQSTGFNPSIPINEANTDSAFKKYDDTEMEISLDHSTGMTLMNG---------- 260

  Fly   103 VEDNADTNANVEKPQEGG--APDAEADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQE 165
              |.|..:....:|::.|  ..|...:|::.::..:||.|.||.:..||.:...:|:|..|:|||
Frog   261 --DGAHEHQAEAEPKQNGHEMGDQTEEGNEQEVIVIQDTGFTVKVQVPGVETFSIQVSPQEMVQE 323

  Fly   166 IHQLLMDREETCHRTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRD 230
            |||:|||||:||||||||||||...||||||||:|...::||.:||||||||:|||||||||:||
Frog   324 IHQVLMDREDTCHRTCFSLQLDGNVLDNFAELKTIEGFQEGSVLKVVEEPYTVREARIHVRHIRD 388

  Fly   231 LLKNLDPADAYNGIDCTSLTYLNTITQGDLLD-----KKRTRPDSVDCTPPEYVTPGVSDPPILP 290
            |||:|||:||:||:||.||::|:..|.|||.|     ||....:.:|||||||:.||..:.|:.|
Frog   389 LLKSLDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKKKKKGNELEQIDCTPPEYILPGSKERPLSP 453

  Fly   291 LHPNVKNAKGPQALKVLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDD 355
            |.|..|:.|..|.|||.|.|.||||||.||:|||||||||:||||:...|:|.::||::||||..
Frog   454 LQPQNKDWKPLQCLKVFTMSGWNPPPGNRKMHGDLMYLYVITMEDRHVSITASTRGFYLNQSTAY 518

  Fly   356 TFNPKPDNPSHLSHSLIDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTV 420
            .|||||.|||.|||||::||:.:||:|::.|..:||:|..||.|||:|||:|:|.|.||.:||.:
Frog   519 NFNPKPANPSFLSHSLVELLNQVSPTFKKNFAALQKKRVQRHPFERIATPFQLYSWTAPQVEHAM 583

  Fly   421 DAIRAEDAFSSKLGYEEHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRG 485
            |.:|||||::|:||||||||||||||||||||||||.||.|||||||||||||||.||..|||||
Frog   584 DCVRAEDAYTSRLGYEEHIPGQTRDWNEELQTTRELTRKNLPERLLRERAIFKVHSDFTAAATRG 648

  Fly   486 AMAVIDGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNA 550
            |||||||||:||||.|:||||||||||||||:|||||||||:.|||:||:|:|..||:|||.|||
Frog   649 AMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDSAAYVSPTNDLNGVRAYNA 713

  Fly   551 VDIEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGK 615
            ||:||||||||||||||||||||||||||||||||||||:||||||||||:|||||||||.:..:
Frog   714 VDVEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVIYGSIDFGKTVVSHPKYLELLEKTSR 778

  Fly   616 HLKILPHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDM 680
            .|||..|.|||::||.|||||||||||||||||||||||||||||||:|||.::...:.:|...|
Frog   779 PLKIQKHTVLNDKDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVEGETMPEECTKM 843

  Fly   681 GFPIEHRHKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASK 745
            |||.|||||||||||||::||:|.|::.|:::||..|.|       :|:....|...|.:.|:.:
Frog   844 GFPKEHRHKLCCLRQELVDAFVEHRYLLFMKLAAMHLMQ-------QKASIKDVLGTEASTASEQ 901

  Fly   746 VNGAEKPDDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSNE---VQAAEVVKRACAA 807
            :.|         ....|||::....|||:       :::.:..:|...|   .::.||:.:||.|
Frog   902 LEG---------NGPSEEKEDLDLDGEAQ-------LKQLEETMAAHKETVDTRSKEVILKACQA 950

  Fly   808 VGSLKEKEFDFRFNPDVFSPGIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSS 872
            |||:....||.|||||:||||:|..: |....:..||.|:::||.|::..|||..||:.:.||..
Frog   951 VGSISNTSFDIRFNPDIFSPGVRFPN-ESQEEVQNQKQLLKDAAAFVLTCQIPCLIKDCLDHSVV 1014

  Fly   873 PIDGQSLTESLHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTE 934
            |:||.:|.|::|..|||:|||||||.::.:.|   ::|::::|.:.|:|.|:.|||:.||:|..|
Frog  1015 PMDGTTLAEAMHQRGINMRYLGKVIDVVRKFPVPSQLDHIYKILISEVITRSAKHIFKTYLQGVE 1079

  Fly   935 PLHLSAAISHFLNCLLTNGPVNPA-VSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGS 998
            ...|||||||||||.|::.|.:.| :.|:|...|:         ||.|     ::.:..||.:.:
Frog  1080 LSALSAAISHFLNCFLSSFPNSVAHLQSDELVSKK---------KSKK-----RRNRNLGNTDNT 1130

  Fly   999 SSGSSNSSSASDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVG 1063
            :           |...:|:.||:.|..|||.|:|:.|:|::::.|:..|.:.:|||:|..|:|||
Frog  1131 A-----------WANTSPQELWKNICSEAKSYFDFNLECENVDQAMEVYNLQKISLLREICIKVG 1184

  Fly  1064 IQVLLREYNFESKHKPTFGDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISG 1128
            ||:||:||||:|||||||.::||:|:||:|||::|:||||::|:.:||||:|||..|||.|||:.
Frog  1185 IQILLKEYNFDSKHKPTFTEEDILNIFPVVKHVNPKATDAFHFFQSGQAKVQQGYLKEGCELINE 1249

  Fly  1129 ALNLLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHL 1193
            ||||.|||:||:|.|..:|||:||||:|::||..:||:.||:||:||||:.|::||||:.||.||
Frog  1250 ALNLFNNVYGAMHVEICACLRLLARLNYIMGDYSEALSNQQKAVLMSERIQGVEHPSTVQEYMHL 1314

  Fly  1194 SLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKL 1258
            :||.|||..|..||.|||||||||:|:.||.|||:||:||||.|:||.:.||:|||||:|:||.:
Frog  1315 ALYCFANNQVSTSLNLLYRARYLMLLVYGEGHPEMALLDSNIGLVLHGVMEYDLSLRFLENALTI 1379

  Fly  1259 NLKYFGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLT 1323
            |.||.|.|.:.||||:||:||.....|:|||||.:||:.|:.||:||||.|||||:|:|.|:.||
Frog  1380 NSKYHGVKSLKVALSHHLVARVYETKGEFRSALQHEKDGYTIYKNQLGEQHEKTRESSEYLKYLT 1444

  Fly  1324 QQAVLLQRKMNDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEK 1388
            ||||.|||.||:||.:|. .:::.|:..|.|||.|||:.||.||||||:.:|:||:..:::|:::
Frog  1445 QQAVALQRTMNEIYKNGS-NANIMPLKFTAPSMTSVLEQLNIINGILFIPLSQKDLEHLKAEVQR 1508

  Fly  1389 ------------HFKTDSTENEVNDAINSIVAAANNNGEAED 1418
                        :.:..:.|.|:::..:|.:.||:...|:.|
Frog  1509 RQQLQEAIKGAENHEAKTKEPEMSETSDSNINAASVAPESSD 1550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	54/72 (75%)
		DUF727	<324..387	CDD:283065	37/62 (60%)
		CLU	445..665	CDD:289977	185/219 (84%)
		eIF3_p135	872..1073	CDD:289571	79/204 (39%)
		TPR_12	1098..1177	CDD:290160	48/78 (62%)
		TPR_10	1146..1184	CDD:290111	21/37 (57%)
		TPR_12	1183..1261	CDD:290160	51/77 (66%)
		TPR repeat	1190..1215	CDD:276809	16/24 (67%)
		TPR_12	1225..1303	CDD:290160	45/77 (58%)
		TPR repeat	1228..1258	CDD:276809	19/29 (66%)
cluh	XP_012812739.1	CLU_N	317..390	CDD:291703	54/72 (75%)
		CLU	608..828	CDD:289977	185/219 (84%)
		eIF3_p135	1014..1194	CDD:289571	79/204 (39%)
		TPR_12	1262..1334	CDD:290160	42/71 (59%)
		TPR_10	1267..1305	CDD:290111	21/37 (57%)
		TPR repeat	1308..1336	CDD:276809	17/27 (63%)
		TPR_12	1346..1424	CDD:290160	45/77 (58%)
		TPR repeat	1349..1379	CDD:276809	19/29 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I779
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9063
Inparanoid	1	1.050	1479	1.000	Inparanoid score	I108
OMA	1	1.010	-	-		QHG54861
OrthoDB	1	1.010	-	-		D48405at33208
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	1	1.000	-	-		otm48059
Panther	1	1.100	-	-	LDO	PTHR12601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R213
SonicParanoid	1	1.000	-	-		X1595
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110