DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and Cluh

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	NP_001074627.1	Gene:	Cluh / 74148	MGIID:	1921398	Length:	1353	Species:	Mus musculus

Alignment Length:	1448	Identity:	747/1448 - (51%)
Similarity:	1001/1448 - (69%)	Gaps:	130/1448 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 ATKASGKAKENNNTAGGKKNLNPNSNQQNSNQNLVNGNGTAADGPAAKKKGKKNRNKSPTEPTTE 86
            |...:..|:|:.:.||||                  |...|||.|:
Mouse    10 AAAPADSAREHGSQAGGK------------------GRPNAADLPS------------------- 37

  Fly    87 AVLSNGHAEKPTVVDAVEDNADTNANVEKPQEGGAPDAEADGDDI---DLDALQDIGITVNISSP 148
            .:|.||        |..|:........|.|:|.|..:.| .||:.   ::..:||.|.:|.|.:|
Mouse    38 VMLLNG--------DCSENLKKEEGTSEPPRENGLDEGE-PGDETTGQEVIVIQDTGFSVKILAP 93

  Fly   149 GADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVE 213
            |.:...:|:|..|:||||||:|||||:|||||||||.||...||:|:||:|:..|::||.::|||
Mouse    94 GIEPFSLQVSPQEMVQEIHQVLMDREDTCHRTCFSLHLDGNMLDHFSELRSVEGLQEGSVLRVVE 158

  Fly   214 EPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLNTITQGDLLD----KKRTRPDSVDCT 274
            ||||:|||||||||||||||:|||:||:||:||.||::|:..|.|||.|    ||....|.:|||
Mouse   159 EPYTVREARIHVRHVRDLLKSLDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKRKKGLEMDPIDCT 223

  Fly   275 PPEYVTPGVSDPPILPLHPNVKNAKGPQALKVLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFH 339
            ||||:.||..:.|:.||.|..::.|..|.|||||.|.||||||.||:|||||||:|:|.||::..
Mouse   224 PPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMYLFVITAEDRQVS 288

  Fly   340 ISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHISPSFRRAFQTIQKRRTMRHAFERVAT 404
            |:|.::||::||||...|||||.:|..|||||::||:.|||:|::.|..:||:|..||.|||:||
Mouse   289 ITASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELLNQISPTFKKNFAVLQKKRVQRHPFERIAT 353

  Fly   405 PYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIPGQTRDWNEELQTTRELPRKTLPERLLRER 469
            |:|||.|.||..||.:|.:|||||::|:|||||||||||||||||||||||||||.|||||||||
Mouse   354 PFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIPGQTRDWNEELQTTRELPRKNLPERLLRER 418

  Fly   470 AIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDHYKELGGDAAA 534
            ||||||.||..||||||||||||||:||||.|:||||||||||||||:|||||||||:.|||.||
Mouse   419 AIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAA 483

  Fly   535 FVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKT 599
            :|||..||:|||.|||||:||||||||||||||||||||||||||||||:|||||:|||||||||
Mouse   484 YVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKT 548

  Fly   600 VLSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVN 664
            |:|||:|||||.:..:.||||.|.|||:|||.|||||||||||||||||||||||||||||||:|
Mouse   549 VVSHPRYLELLERTSRPLKILRHRVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLN 613

  Fly   665 FLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKS 729
            ||.:...:|.:|....|||..||||||||||||::||:|.|::.|:::||.:|.      |.:.|
Mouse   614 FLPVPGEELPEECSRAGFPRTHRHKLCCLRQELVDAFVEHRYLLFMKLAALQLM------QQKAS 672

  Fly   730 EANPVPALEGAEAASKVNGAEKPDDKEKKNEEE-------EKKERSTSGEARAAAIVNAIREAQS 787
            :.....:||        ||. .|...|.|:|:.       |::..|.||.|:...:...|.....
Mouse   673 KVETTTSLE--------NGG-LPSSAETKSEDSIGPEAGCEEEGSSVSGLAKVKELAETIASDDG 728

  Fly   788 NVATSNEVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSPGIRHADGEEGTSLAKQKVLVQEAAE 852
            .|    :.::.||::.||.||||:....||.|||||:||||:|..:..: ..:..||.|:::||.
Mouse   729 TV----DPRSREVIRNACKAVGSISSTAFDIRFNPDIFSPGVRFPESCQ-DEVRDQKQLLKDAAA 788

  Fly   853 FLVLKQIPAFIKEHMSHSSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMP---RMDYLHRIAV 914
            ||:..|||..:|:...::..|:||.:|.|.:...|||:||||||:.::.:.|   ::|::::|.:
Mouse   789 FLLSCQIPGLVKDCTEYAVLPMDGATLAEVMRQRGINMRYLGKVLDLVLRSPARDQLDHIYKIGI 853

  Fly   915 LELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTNGPVNPAV---SSEEAHKKRGNGGKHNK 976
            .|||.|:.|||:.||:|..|...|||||||||||.|::.| ||..   :.|...|||      ||
Mouse   854 GELITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYP-NPVAHLPADELLSKKR------NK 911

  Fly   977 HKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSASDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIE 1041
            .:.::                 ..|::::::   |.:|||:.||:.|..|||.|:|:.|:|||::
Mouse   912 RRKNR-----------------PPGAADNTA---WAVMTPQELWKNICHEAKNYFDFTLECDSVD 956

  Fly  1042 TAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTFGDDDIVNVFPIVKHISPRATDAYNF 1106
            .||..||:.:|:|:|...||.|||:||:||:|:|:|||.|.::|::|:||:|||::|:|:||::|
Mouse   957 QAVETYGLQKITLLREISLKTGIQILLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKASDAFHF 1021

  Fly  1107 YTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRA 1171
            :.:||||:|||..|||.|||:.||||.|||:||:|.|..:|||:||||.|::||..:||:.||:|
Mouse  1022 FQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLHYIMGDYAEALSNQQKA 1086

  Fly  1172 VIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNIS 1236
            |:|||||.|::||:||.||.||:||.||:..:..:|.|||||||||:|:.||||||:||:|:||.
Mouse  1087 VLMSERVMGIEHPNTIQEYMHLALYCFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIG 1151

  Fly  1237 LILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFY 1301
            |:||.:.||:|||||:|:||.:..||.|.|.:.||||:||:||......:|||||.:|||.|:.|
Mouse  1152 LVLHGVMEYDLSLRFLENALAVTTKYHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIY 1216

  Fly  1302 KSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTI 1366
            |:||||:||||::|:|.|:.||||||.|||.||:||.:|. ::::||:..|.|||.|||:.||.|
Mouse  1217 KTQLGEDHEKTKESSEYLKCLTQQAVALQRTMNEIYRNGS-SANIPPLKFTAPSMTSVLEQLNVI 1280

  Fly  1367 NGILFVKISRKDIVKVRSEIEKHFKTDSTENEVNDAINSIVAAANNNGEAED-AVSKDIKEQPEA 1430
            |||||:.:|:||:..:::|:.:.              :.:..|..|..:||: .::.:.:.:||.
Mouse  1281 NGILFIPLSQKDLENLKAEVARR--------------HQLQEANRNRDKAEEQPMAPEPEPEPER 1331

  Fly  1431 GKQLTNGDKAAATEATSS 1448
            ..: ..|....|.|..||
Mouse  1332 AVE-DMGSPQTAKEGPSS 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	51/72 (71%)
		DUF727	<324..387	CDD:283065	34/62 (55%)
		CLU	445..665	CDD:289977	187/219 (85%)
		eIF3_p135	872..1073	CDD:289571	82/206 (40%)
		TPR_12	1098..1177	CDD:290160	47/78 (60%)
		TPR_10	1146..1184	CDD:290111	22/37 (59%)
		TPR_12	1183..1261	CDD:290160	47/77 (61%)
		TPR repeat	1190..1215	CDD:276809	13/24 (54%)
		TPR_12	1225..1303	CDD:290160	43/77 (56%)
		TPR repeat	1228..1258	CDD:276809	18/29 (62%)
Cluh	NP_001074627.1	CLU_N	104..177	CDD:291703	51/72 (71%)
		CLU	394..614	CDD:289977	187/219 (85%)
		eIF3_p135	809..988	CDD:289571	82/205 (40%)
		TPR_12	1056..1128	CDD:290160	40/71 (56%)
		TPR_10	1061..1100	CDD:290111	23/38 (61%)
		TPR repeat	1062..1088	CDD:276809	15/25 (60%)
		TPR repeat	1101..1131	CDD:276809	17/29 (59%)
		TPR_12	1140..1217	CDD:290160	42/76 (55%)
		TPR repeat	1144..1172	CDD:276809	17/27 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838925
Domainoid	1	1.000	394	1.000	Domainoid score	I766
eggNOG	1	0.900	-	-		E1_KOG1839
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9063
Inparanoid	1	1.050	1419	1.000	Inparanoid score	I118
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54861
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	1	1.000	-	-		oto92817
orthoMCL	1	0.900	-	-		OOG6_102505
Panther	1	1.100	-	-	LDO	PTHR12601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R213
SonicParanoid	1	1.000	-	-		X1595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790