DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and cluha

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	NP_001071028.1	Gene:	cluha / 562666	ZFINID:	ZDB-GENE-061103-457	Length:	1400	Species:	Danio rerio

Alignment Length:	1400	Identity:	746/1400 - (53%)
Similarity:	992/1400 - (70%)	Gaps:	121/1400 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 AADGPAAKKKGKKNRNKSPTEPTTEAVLSNGHAEKPTVV--DAVEDNADTNANVEKPQEG-GAPD 123
            |.||..|..||        |....||..:.||..:..|:  ||..|.|:   ..:..|:| |..|
Zfish    21 ARDGETANSKG--------TTSKKEASCACGHGVETAVMNGDAGHDQAE---EADSKQDGSGDAD 74

  Fly   124 AEADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDN 188
            ...|.::.::..:||.|.||.|.:||.:...:|:|..|:||||||:|||||:||||||||||||.
Zfish    75 QAEDANEQEVIVIQDTGFTVKIQAPGTEPFDLQVSPQEMVQEIHQVLMDREDTCHRTCFSLQLDG 139

  Fly   189 VTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLN 253
            ..||||||||||..|::||.:||||||||:|||||||||:|||||:|||:|||||:||.||::|:
Zfish   140 NVLDNFAELKSIEGLQEGSLLKVVEEPYTVREARIHVRHIRDLLKSLDPSDAYNGVDCNSLSFLS 204

  Fly   254 TITQGDLLD-----KKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNVKNAKGPQALKVLTTSAWN 313
            ..::|||.|     ||.:..:.:||||||::.||..:.|::||.|..|:.|..|.|||||.|:||
Zfish   205 VFSEGDLGDTGKRKKKGSELEQIDCTPPEHILPGSKERPLVPLQPQNKDWKPMQCLKVLTMSSWN 269

  Fly   314 PPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHI 378
            ||||.||:||||||||:||:||:...|:|.::||::||||...|:|||.|||.|||||::|||.|
Zfish   270 PPPGNRKMHGDLMYLYIVTVEDRHVSITASTRGFYLNQSTTYNFSPKPANPSFLSHSLVELLSQI 334

  Fly   379 SPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIPGQT 443
            |.:|::.|.|:||:|..||.|||:|||:|||.|.||.::|.:|.:|||||::|:|||||||||||
Zfish   335 SAAFKKNFTTLQKKRVQRHPFERIATPFQVYSWTAPQIDHAMDCVRAEDAYTSRLGYEEHIPGQT 399

  Fly   444 RDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMF 508
            |||||||||||||.||.|||||||||||||||.||..||||||||||||||:||||||:|:||||
Zfish   400 RDWNEELQTTRELSRKNLPERLLRERAIFKVHSDFAAAATRGAMAVIDGNVMAINPGEETRMQMF 464

  Fly   509 IWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTA 573
            ||||||||:||||||||:|||||:||..||..||:|||.|:|||:||||||||||||||||||||
Zfish   465 IWNNIFFSLGFDVRDHYRELGGDSAAHAAPTNDLNGVRAYSAVDVEGLYTLGTVVVDYRGYRVTA 529

  Fly   574 QSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSV 638
            ||||||||||||||||:||||||||||:|||||||||.:..:.||:..|.||||:|..|||||||
Zfish   530 QSIIPGILEREQEQSVIYGSIDFGKTVVSHPKYLELLEKTSRPLKVQRHAVLNEKDSAVELCSSV 594

  Fly   639 ECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEAFIE 703
            ||||||||||||||||||||||||:|||.::..:|:.|...:|||.:|||:|.||||||:|||:|
Zfish   595 ECKGIIGNDGRHYILDLLRTFPPDLNFLPVEGEELTPESQKLGFPRQHRHRLACLRQELIEAFVE 659

  Fly   704 DRHVNFIRIAAARLQQLTTIKQS----------------------------------------EK 728
            .|::.|:::||.:|.|....|..                                        |.
Zfish   660 HRYLLFMKMAALQLMQQKANKDKTAALQDSNAAGAGSENKPLALESCDGTPDSPTSSESTLTPED 724

  Fly   729 SEANPV---PALEGAEAASKV-----NGAEKPDDKEKKNE------EEEKKERSTSGEARAAAIV 779
            |||..|   .:.|..||.::|     ||..:|...|::|.      |.::.:.:..|.|:|..:.
Zfish   725 SEATTVSENSSAENQEAMTEVPVASINGTHEPLAAERQNGGCDGPLEGKEADENIPGLAQAKELA 789

  Fly   780 NAI-REAQSNVATSNEVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSPGIRHADGEEGTSLAKQ 843
            .:: .|..|.:    :.::.|||..||.||||:....||.|||||:||||:|..| :....:.||
Zfish   790 ESLAAEDGSGI----DPKSREVVLNACKAVGSISNTSFDIRFNPDIFSPGVRFPD-DSNDDIKKQ 849

  Fly   844 KVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTESLHSHGINVRYLGKVIKILSQMP---R 905
            |.|:::||.|||..|||:.:|:.:.|||.|:||.:|||:||..||||||||.|::.:..||   :
Zfish   850 KQLLKDAAAFLVSCQIPSLVKDCLDHSSLPMDGATLTEALHQRGINVRYLGTVLEFMDNMPAKAQ 914

  Fly   906 MDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTNG-------PVNPAVSSEE 963
            :::::||.:.|||.|..|||:.||:|..:...||||:|:||||||::.       |.:..||.::
Zfish   915 LEHIYRIGISELITRCAKHIFKTYLQGVDLSALSAAVSYFLNCLLSSFPDAVAHLPADELVSRKK 979

  Fly   964 AHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSASDWTLMTPRSLWQQIRKEAK 1028
            :.|:|                           |....|..|::    |..:||..||:.|..||.
Zfish   980 SRKRR---------------------------NRVPGGGDNTA----WASLTPSELWKNITSEAH 1013

  Fly  1029 VYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTFGDDDIVNVFPIV 1093
            .|:::.|.|:|::.||.|||:.:|:|:|...:|.|||:|::||||:|:|||.|.::||:|:||:|
Zfish  1014 GYYNFSLQCESVDQAVEKYGLQKITLLREISIKTGIQILIKEYNFDSRHKPAFTEEDILNIFPVV 1078

  Fly  1094 KHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRMLARLSYLL 1158
            ||::|:|:||::|:.:||||:|||..|||.|||:.||||.|||:||:|.|..:|||:||||:|::
Zfish  1079 KHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICACLRLLARLNYIM 1143

  Fly  1159 GDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARYLMVLICGE 1223
            ||..:||:.||:||:|||||.|::||:||.||.||:||.||||.:..:|||||||||||:::|||
Zfish  1144 GDHPEALSNQQKAVLMSERVLGIEHPNTIQEYMHLALYCFANGQLSTALKLLYRARYLMLVVCGE 1208

  Fly  1224 DHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMARTQSCMGDFR 1288
            ||||:||:||||.|:||.:.||:|||||:|:||.:|.||.|.:.:.||||:||:||......:||
Zfish  1209 DHPEMALLDSNIGLVLHGVMEYDLSLRFLENALAINTKYHGPRSLKVALSHHLVARVYESKAEFR 1273

  Fly  1289 SALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGKLTSDLPPIHITP 1353
            |||.:|||.|:.||:|:||.||||::|:|.|:.||||||.|||.||:||.:|. .:.:.|:..|.
Zfish  1274 SALQHEKEGYTIYKNQVGEAHEKTKESSEYLKYLTQQAVALQRTMNEIYKNGS-NASIMPLKFTA 1337

  Fly  1354 PSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEK 1388
            |||.|||:.||.||||:|:.:|:||:..:::|:::
Zfish  1338 PSMASVLEQLNIINGIIFIPLSQKDLENLKAEVQR 1372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	56/72 (78%)
		DUF727	<324..387	CDD:283065	36/62 (58%)
		CLU	445..665	CDD:289977	184/219 (84%)
		eIF3_p135	872..1073	CDD:289571	77/210 (37%)
		TPR_12	1098..1177	CDD:290160	47/78 (60%)
		TPR_10	1146..1184	CDD:290111	22/37 (59%)
		TPR_12	1183..1261	CDD:290160	52/77 (68%)
		TPR repeat	1190..1215	CDD:276809	16/24 (67%)
		TPR_12	1225..1303	CDD:290160	44/77 (57%)
		TPR repeat	1228..1258	CDD:276809	19/29 (66%)
cluha	NP_001071028.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		8/25 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	56..78		6/24 (25%)
		CLU_N	110..183	CDD:291703	56/72 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..243		11/30 (37%)
		CLU	401..621	CDD:289977	184/219 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..741		6/56 (11%)
		eIF3_p135	879..1058	CDD:289571	77/209 (37%)
		TPR 1	1088..1121		20/32 (63%)
		TPR_12	1126..1198	CDD:290160	43/71 (61%)
		TPR 2	1130..1163		19/32 (59%)
		TPR_10	1131..1170	CDD:290111	23/38 (61%)
		TPR repeat	1132..1158	CDD:276809	15/25 (60%)
		TPR 3	1172..1205		22/32 (69%)
		TPR repeat	1172..1200	CDD:276809	18/27 (67%)
		TPR_12	1210..1288	CDD:290160	44/77 (57%)
		TPR repeat	1213..1243	CDD:276809	19/29 (66%)
		TPR 4	1214..1247		20/32 (63%)
		TPR repeat	1256..1281	CDD:276809	13/24 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1377..1400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582779
Domainoid	1	1.000	387	1.000	Domainoid score	I766
eggNOG	1	0.900	-	-		E1_KOG1839
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9063
Inparanoid	1	1.050	1460	1.000	Inparanoid score	I110
OMA	1	1.010	-	-		QHG54861
OrthoDB	1	1.010	-	-		D48405at33208
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	1	1.000	-	-		oto41389
orthoMCL	1	0.900	-	-		OOG6_102505
Panther	1	1.100	-	-	LDO	PTHR12601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R213
SonicParanoid	1	1.000	-	-		X1595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800