DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and Cluh

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	XP_038941934.1	Gene:	Cluh / 303300	RGDID:	1307222	Length:	1523	Species:	Rattus norvegicus

Alignment Length:	1472	Identity:	746/1472 - (50%)
Similarity:	1015/1472 - (68%)	Gaps:	107/1472 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LETEAKNSNATATGDATATATKASGKAKENNNTAGGKKNLNPNSNQQNSNQNLVNGNGTAADGP- 66
            |:.||..|::....:...|..:|....::..:...| ....|.|...       :|.|..:..|
  Rat   127 LKPEASWSSSPEPTNCITTVIEAETGTRDRGSIGPG-PGPGPGSGPG-------SGPGQGSWRPY 183

  Fly    67 --AAKKKGKKNRNKSPTEPTTEAV-LSNGHAEKPTVVDAVEDNADTNANVEKPQEG----GAPDA 124
              .:.:..:..|.:..|.|...:| |.||        |..|:......:.|.|:|.    |.|..
  Rat   184 CHGSSETPEPRRGQLLTVPDPPSVMLLNG--------DCSENLKKEEGSSEPPRENGLDEGEPGE 240

  Fly   125 EADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDNV 189
            |..|.::.:  :||.|.:|.|.:||.:...:|:|..|:||||||:|||||:|||||||||.||..
  Rat   241 ETTGQEVIV--IQDTGFSVKILAPGIEPFSLQVSPQEMVQEIHQVLMDREDTCHRTCFSLHLDGN 303

  Fly   190 TLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLNT 254
            .||:|:||:|:..|::||.::|||||||:|||||||||||||||:|||:||:||:||.||::|:.
  Rat   304 MLDHFSELRSVEGLQEGSVLRVVEEPYTVREARIHVRHVRDLLKSLDPSDAFNGVDCNSLSFLSV 368

  Fly   255 ITQGDL---------LDKKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNVKNAKGPQALKVLTTS 310
            .|.|||         ..||....|.:|||||||:.||..:.|:.||.|..::.|..|.|||||.|
  Rat   369 FTDGDLGALGSSDSGKRKKGLEMDPIDCTPPEYILPGSRERPLCPLQPQNRDWKPLQCLKVLTMS 433

  Fly   311 AWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLL 375
            .||||||.||:|||||||:|:|.||::..::|.::||::||||...|||||.:|..|||||::||
  Rat   434 GWNPPPGNRKMHGDLMYLFVITAEDRQVSVTASTRGFYLNQSTAYHFNPKPASPRFLSHSLVELL 498

  Fly   376 SHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIP 440
            :.|||:|::.|..:||:|..||.|||:|||:|||.|.||..||.:|.:|||||::|:||||||||
  Rat   499 NQISPTFKKNFAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRAEDAYTSRLGYEEHIP 563

  Fly   441 GQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKM 505
            |||||||||||||||||||.|||||||||||||||.||..||||||||||||||:||||.|:|||
  Rat   564 GQTRDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVIDGNVMAINPSEETKM 628

  Fly   506 QMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYR 570
            |||||||||||:|||||||||:.|||.||:|||..||:|||.|||||:|||||||||||||||||
  Rat   629 QMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEGLYTLGTVVVDYRGYR 693

  Fly   571 VTAQSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHVVLNERDEPVELC 635
            |||||||||||||:|||||:||||||||||:|||:|||||.:..:.||||.|.|||:|||.||||
  Rat   694 VTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPLKILRHRVLNDRDEEVELC 758

  Fly   636 SSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEA 700
            |||||||||||||||||||||||||||:|||.:...:|.:|....|||..||||||||||||::|
  Rat   759 SSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPEECSRAGFPRTHRHKLCCLRQELVDA 823

  Fly   701 FIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAEKPDDKEKKNEEEEKK 765
            |:|.|::.|:::||.:|.      |.:.|:.:...:||        ||. .|...|.|:|:....
  Rat   824 FVEHRYLLFMKLAALQLM------QQKASKVDTSTSLE--------NGG-PPSSTETKSEDSLGS 873

  Fly   766 ERSTSGEARAAAIVNAIREAQSNVATSN---EVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSP 827
            |.....|..:.:.:..::|....:|:.:   :.::.||::.||.||||:....||.|||||:|||
  Rat   874 EAGCEEEGSSVSGLAKVKELAETIASDDGTVDPRSREVIQNACKAVGSVSSTAFDIRFNPDIFSP 938

  Fly   828 GIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTESLHSHGINVRY 892
            |:|..:..: ..:..||.|:::||.||:..|||..:|:...::..|:||.:|.|.:...|||:||
  Rat   939 GVRFPESCQ-DEVRDQKQLLKDAAAFLLSCQIPGLVKDCTEYAVLPMDGATLAEVMRQRGINMRY 1002

  Fly   893 LGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTNGP 954
            ||||:.::.:.|   ::|::::|.:.|||.|:.|||:.||:|..|...|||||||||||.|::.|
  Rat  1003 LGKVLDLVLRSPARDQLDHIYKIGIGELITRSAKHIFKTYLQGVELSGLSAAISHFLNCFLSSYP 1067

  Fly   955 VNPAV---SSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSASDWTLMTP 1016
             ||..   :.|...|||      ||.:.::                 ..|::::::   |.:|||
  Rat  1068 -NPVAHLPADELLSKKR------NKRRKNR-----------------PPGAADNTA---WAVMTP 1105

  Fly  1017 RSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTF 1081
            :.||:.|.:|||.|:|:.|:|||::.||..||:.:|:|:|...||.|:|:||:||:|:|:|||.|
  Rat  1106 QELWKNICQEAKNYFDFTLECDSVDQAVETYGLQKITLLREISLKTGMQILLKEYSFDSRHKPAF 1170

  Fly  1082 GDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGS 1146
            .::|::|:||:|||::|:|:||::|:.:||||:|||..|||.|||:.||||.|||:||:|.|..:
  Rat  1171 TEEDVLNIFPVVKHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALNLFNNVYGAMHVEICA 1235

  Fly  1147 CLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLY 1211
            |||:||||.|::||..:||:.||:||:|||||.|::||:||.||.||:||.||:..:..:|.|||
  Rat  1236 CLRLLARLHYIMGDYAEALSNQQKAVLMSERVVGIEHPNTIQEYMHLALYCFASSQLSTALSLLY 1300

  Fly  1212 RARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHL 1276
            ||||||:|:.||||||:||:|:||.|:||.:.||:|||||:|:||.:..||.|.|.:.||||:||
  Rat  1301 RARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVTTKYHGPKALKVALSHHL 1365

  Fly  1277 MARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGK 1341
            :||......:|||||.:|||.|:.||:||||:|||||:|:|.|:.||||||.|||.||:||.:|.
  Rat  1366 VARVYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTRESSEYLKCLTQQAVALQRTMNEIYRNGS 1430

  Fly  1342 LTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFKTDSTENEVNDAINSI 1406
             ::::||:..|.|||.|||:.||.||||||:.:|:||:..:::|:.:.              :.:
  Rat  1431 -SANIPPLKFTAPSMASVLEQLNVINGILFIPLSQKDLENLKAEVARR--------------HQL 1480

  Fly  1407 VAAANNNGEAEDAVSKDIKEQPEAGKQLTN-GDKAAATEATS 1447
            ..|:.|..:||:.::    .:||..:.|.. |....|.|..|
  Rat  1481 QEASRNRDKAEEPMA----TEPEPDRALEGMGSPQTAKEGPS 1518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	51/72 (71%)
		DUF727	<324..387	CDD:283065	33/62 (53%)
		CLU	445..665	CDD:289977	187/219 (85%)
		eIF3_p135	872..1073	CDD:289571	81/206 (39%)
		TPR_12	1098..1177	CDD:290160	47/78 (60%)
		TPR_10	1146..1184	CDD:290111	22/37 (59%)
		TPR_12	1183..1261	CDD:290160	47/77 (61%)
		TPR repeat	1190..1215	CDD:276809	13/24 (54%)
		TPR_12	1225..1303	CDD:290160	43/77 (56%)
		TPR repeat	1228..1258	CDD:276809	18/29 (62%)
Cluh	XP_038941934.1	CLU_N	273..346	CDD:405693	51/72 (71%)
		CLU	568..788	CDD:404173	187/219 (85%)
		eIF3_p135	981..1162	CDD:403880	81/207 (39%)
		TPR_12	1199..1261	CDD:315987	38/61 (62%)
		TPR repeat	1236..1262	CDD:276809	15/25 (60%)
		TPR_12	1237..1302	CDD:315987	37/64 (58%)
		TPR repeat	1275..1305	CDD:276809	17/29 (59%)
		TPR_12	1316..1391	CDD:315987	40/74 (54%)
		TPR repeat	1318..1346	CDD:276809	17/27 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342726
Domainoid	1	1.000	393	1.000	Domainoid score	I741
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9063
Inparanoid	1	1.050	1440	1.000	Inparanoid score	I107
OMA	1	1.010	-	-		QHG54861
OrthoDB	1	1.010	-	-		D48405at33208
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	1	1.000	-	-		oto96371
orthoMCL	1	0.900	-	-		OOG6_102505
Panther	1	1.100	-	-	LDO	PTHR12601
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1595
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910