DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and CLUH

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	XP_024306443.1	Gene:	CLUH / 23277	HGNCID:	29094	Length:	1583	Species:	Homo sapiens

Alignment Length:	1480	Identity:	753/1480 - (50%)
Similarity:	1015/1480 - (68%)	Gaps:	139/1480 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LETEAKNSNATATGDATATATKASGKAKENNNTAGGKKNLNPNSNQQNSNQNLVNGNGTAADGP- 66
            ||.:|:.......|.|.|                 |...|.|.:::.:|            .||
Human   185 LERDARQGECALPGAAMA-----------------GLAPLKPEASRSSS------------PGPT 220

  Fly    67 ------AAKKKGKKNRNKSPTEPTTEAVLSNGHAEK--------------PTVV----DAVEDNA 107
                  .|.:.|.:|...:..|..:.....:||.|.              |:|:    |..|...
Human   221 GCIRARVAAEAGTRNPGNAGAELESWLPCCHGHPETPEPRGGQLPTAPELPSVMLLNGDCPESLK 285

  Fly   108 DTNANVEKPQEGGAPDAEADGDDI---DLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQL 169
            ...|..|.|:|.|..:| ..||:.   ::..:||.|.:|.|.:||.:...:|:|..|:||||||:
Human   286 KEAAAAEPPRENGLDEA-GPGDETTGQEVIVIQDTGFSVKILAPGIEPFSLQVSPQEMVQEIHQV 349

  Fly   170 LMDREETCHRTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKN 234
            |||||:|||||||||.||...||:|:||:|:..|::||.::|||||||:|||||||||||||||:
Human   350 LMDREDTCHRTCFSLHLDGNVLDHFSELRSVEGLQEGSVLRVVEEPYTVREARIHVRHVRDLLKS 414

  Fly   235 LDPADAYNGIDCTSLTYLNTITQGDLLD----KKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNV 295
            |||:||:||:||.||::|:..|.|||.|    ||....|.:|||||||:.||..:.|:.||.|..
Human   415 LDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKRKKGLEMDPIDCTPPEYILPGSRERPLCPLQPQN 479

  Fly   296 KNAKGPQALKVLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPK 360
            ::.|..|.|||||.|.||||||.||:|||||||:|:|.||::..|:|.::||::||||...||||
Human   480 RDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMYLFVITAEDRQVSITASTRGFYLNQSTAYHFNPK 544

  Fly   361 PDNPSHLSHSLIDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRA 425
            |.:|..|||||::||:.|||:|::.|..:||:|..||.|||:|||:|||.|.||..||.:|.:||
Human   545 PASPRFLSHSLVELLNQISPTFKKNFAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRA 609

  Fly   426 EDAFSSKLGYEEHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVI 490
            |||::|:|||||||||||||||||||||||||||.|||||||||||||||.||..||||||||||
Human   610 EDAYTSRLGYEEHIPGQTRDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVI 674

  Fly   491 DGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEG 555
            ||||:||||.|:||||||||||||||:|||||||||:.|||.||:|||..||:|||.|||||:||
Human   675 DGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEG 739

  Fly   556 LYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKIL 620
            ||||||||||||||||||||||||||||:|||||:||||||||||:|||:|||||.:..:.||||
Human   740 LYTLGTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPLKIL 804

  Fly   621 PHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIE 685
            .|.|||:|||.|||||||||||||||||||||||||||||||:|||.:...:|.:|....|||..
Human   805 RHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPEECARAGFPRA 869

  Fly   686 HRHKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAE 750
            ||||||||||||::||:|.|::.|:::||.:|.      |...|:.....:||....:|..:.:|
Human   870 HRHKLCCLRQELVDAFVEHRYLLFMKLAALQLM------QQNASQLETPSSLENGGPSSLESKSE 928

  Fly   751 KPDDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSN---EVQAAEVVKRACAAVGSLK 812
            .|..:|..:|||..   |.||.|:       ::|....:|..:   :.::.||::.||.||||:.
Human   929 DPPGQEAGSEEEGS---SASGLAK-------VKELAETIAADDGTADPRSREVIRNACKAVGSIS 983

  Fly   813 EKEFDFRFNPDVFSPGIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQ 877
            ...||.|||||:||||:|..:..: ..:..||.|:::||.||:..|||..:|:.|.|:..|:||.
Human   984 STAFDIRFNPDIFSPGVRFPESCQ-DEVRDQKQLLKDAAAFLLSCQIPGLVKDCMEHAVLPVDGA 1047

  Fly   878 SLTESLHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLS 939
            :|.|.:...|||:||||||::::.:.|   ::|::.:|.:.|||.|:.|||:.||:|..|...||
Human  1048 TLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLS 1112

  Fly   940 AAISHFLNCLLTNGPVNPAV---SSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSG 1001
            |||||||||.|::.| ||..   :.|...|||      ||.:.::                 ..|
Human  1113 AAISHFLNCFLSSYP-NPVAHLPADELVSKKR------NKRRKNR-----------------PPG 1153

  Fly  1002 SSNSSSASDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQV 1066
            ::::::   |.:|||:.||:.|.:|||.|:|::|:|::::.||..||:.:|:|:|...||.||||
Human  1154 AADNTA---WAVMTPQELWKNICQEAKNYFDFDLECETVDQAVETYGLQKITLLREISLKTGIQV 1215

  Fly  1067 LLREYNFESKHKPTFGDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALN 1131
            ||:||:|:|:|||.|.::|::|:||:|||::|:|:||::|:.:||||:|||..|||.|||:.|||
Human  1216 LLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALN 1280

  Fly  1132 LLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLY 1196
            |.|||:||:|.|..:|||:||||.|::||..:||:.||:||:|||||.|.:||:||.||.||:||
Human  1281 LFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALY 1345

  Fly  1197 SFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLK 1261
            .||:..:..:|.|||||||||:|:.||||||:||:|:||.|:||.:.||:|||||:|:||.::.|
Human  1346 CFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTK 1410

  Fly  1262 YFGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQA 1326
            |.|.|.:.||||:||:||......:|||||.:|||.|:.||:||||:||||::|:|.|:.|||||
Human  1411 YHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQA 1475

  Fly  1327 VLLQRKMNDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFK 1391
            |.|||.||:||.:|. ::::||:..|.|||.|||:.||.||||||:.:|:||:..:::|:.:.
Human  1476 VALQRTMNEIYRNGS-SANIPPLKFTAPSMASVLEQLNVINGILFIPLSQKDLENLKAEVARR-- 1537

  Fly  1392 TDSTENEVNDAINSIVAAANNNGEAEDAVSK---------DIKEQPEAGK 1432
                        :.:..|:.|...||:.::.         |:..||.|.|
Human  1538 ------------HQLQEASRNRDRAEEPMATEPAPAGAPGDLGSQPPAAK 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	51/72 (71%)
		DUF727	<324..387	CDD:283065	34/62 (55%)
		CLU	445..665	CDD:289977	187/219 (85%)
		eIF3_p135	872..1073	CDD:289571	81/206 (39%)
		TPR_12	1098..1177	CDD:290160	47/78 (60%)
		TPR_10	1146..1184	CDD:290111	22/37 (59%)
		TPR_12	1183..1261	CDD:290160	47/77 (61%)
		TPR repeat	1190..1215	CDD:276809	13/24 (54%)
		TPR_12	1225..1303	CDD:290160	43/77 (56%)
		TPR repeat	1228..1258	CDD:276809	18/29 (62%)
CLUH	XP_024306443.1	Herpes_ICP4_C	114..>307	CDD:332854	30/151 (20%)
		CLU_N	339..412	CDD:317460	51/72 (71%)
		CLU	629..849	CDD:315818	187/219 (85%)
		eIF3_p135	1041..1222	CDD:315476	81/207 (39%)
		TPR_12	1259..1321	CDD:315987	38/61 (62%)
		TPR repeat	1296..1322	CDD:276809	15/25 (60%)
		TPR_12	1297..1362	CDD:315987	37/64 (58%)
		TPR repeat	1335..1365	CDD:276809	17/29 (59%)
		TPR_12	1376..1451	CDD:315987	40/74 (54%)
		TPR repeat	1378..1406	CDD:276809	17/27 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148841
Domainoid	1	1.000	394	1.000	Domainoid score	I770
eggNOG	1	0.900	-	-		E1_KOG1839
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9063
Inparanoid	1	1.050	1449	1.000	Inparanoid score	I113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54861
OrthoDB	1	1.010	-	-		D48405at33208
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	1	1.000	-	-		oto89248
orthoMCL	1	0.900	-	-		OOG6_102505
Panther	1	1.100	-	-	LDO	PTHR12601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R213
SonicParanoid	1	1.000	-	-		X1595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840