Protein Alignment clu and CLUH

DIOPT Version :10

• Sequence 1: NP_611095.1
• Gene: clu / 36793
• FlyBaseID: FBgn0034087
• Length: 1448
• Species: Drosophila melanogaster
• Sequence 2: XP_054171574.1
• Gene: CLUH / 23277
• HGNCID: 29094
• Length: 1583
• Species: Homo sapiens
• Alignment Length: 1480
• Identity: 753/1480 - (50%)
• Similarity: 1015/1480 - (68%)
• Gaps: 139/1480 - (9%)

  Fly     3 LETEAKNSNATATGDATATATKASGKAKENNNTAGGKKNLNPNSNQQNSNQNLVNGNGTAADGP- 66
            ||.:|:.......|.|.|                 |...|.|.:::.:|            .||
Human   185 LERDARQGECALPGAAMA-----------------GLAPLKPEASRSSS------------PGPT 220

  Fly    67 ------AAKKKGKKNRNKSPTEPTTEAVLSNGHAEK--------------PTVV----DAVEDNA 107
                  .|.:.|.:|...:..|..:.....:||.|.              |:|:    |..|...
Human   221 GCIRARVAAEAGTRNPGNAGAELESWLPCCHGHPETPEPRGGQLPTAPELPSVMLLNGDCPESLK 285

  Fly   108 DTNANVEKPQEGGAPDAEADGDDI---DLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQL 169
            ...|..|.|:|.|..:| ..||:.   ::..:||.|.:|.|.:||.:...:|:|..|:||||||:
Human   286 KEAAAAEPPRENGLDEA-GPGDETTGQEVIVIQDTGFSVKILAPGIEPFSLQVSPQEMVQEIHQV 349

  Fly   170 LMDREETCHRTCFSLQLDNVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKN 234
            |||||:|||||||||.||...||:|:||:|:..|::||.::|||||||:|||||||||||||||:
Human   350 LMDREDTCHRTCFSLHLDGNVLDHFSELRSVEGLQEGSVLRVVEEPYTVREARIHVRHVRDLLKS 414

  Fly   235 LDPADAYNGIDCTSLTYLNTITQGDLLD----KKRTRPDSVDCTPPEYVTPGVSDPPILPLHPNV 295
            |||:||:||:||.||::|:..|.|||.|    ||....|.:|||||||:.||..:.|:.||.|..
Human   415 LDPSDAFNGVDCNSLSFLSVFTDGDLGDSGKRKKGLEMDPIDCTPPEYILPGSRERPLCPLQPQN 479

  Fly   296 KNAKGPQALKVLTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPK 360
            ::.|..|.|||||.|.||||||.||:|||||||:|:|.||::..|:|.::||::||||...||||
Human   480 RDWKPLQCLKVLTMSGWNPPPGNRKMHGDLMYLFVITAEDRQVSITASTRGFYLNQSTAYHFNPK 544

  Fly   361 PDNPSHLSHSLIDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRA 425
            |.:|..|||||::||:.|||:|::.|..:||:|..||.|||:|||:|||.|.||..||.:|.:||
Human   545 PASPRFLSHSLVELLNQISPTFKKNFAVLQKKRVQRHPFERIATPFQVYSWTAPQAEHAMDCVRA 609

  Fly   426 EDAFSSKLGYEEHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVI 490
            |||::|:|||||||||||||||||||||||||||.|||||||||||||||.||..||||||||||
Human   610 EDAYTSRLGYEEHIPGQTRDWNEELQTTRELPRKNLPERLLRERAIFKVHSDFTAAATRGAMAVI 674

  Fly   491 DGNVLAINPGEDTKMQMFIWNNIFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEG 555
            ||||:||||.|:||||||||||||||:|||||||||:.|||.||:|||..||:|||.|||||:||
Human   675 DGNVMAINPSEETKMQMFIWNNIFFSLGFDVRDHYKDFGGDVAAYVAPTNDLNGVRTYNAVDVEG 739

  Fly   556 LYTLGTVVVDYRGYRVTAQSIIPGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKIL 620
            ||||||||||||||||||||||||||||:|||||:||||||||||:|||:|||||.:..:.||||
Human   740 LYTLGTVVVDYRGYRVTAQSIIPGILERDQEQSVIYGSIDFGKTVVSHPRYLELLERTSRPLKIL 804

  Fly   621 PHVVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIE 685
            .|.|||:|||.|||||||||||||||||||||||||||||||:|||.:...:|.:|....|||..
Human   805 RHQVLNDRDEEVELCSSVECKGIIGNDGRHYILDLLRTFPPDLNFLPVPGEELPEECARAGFPRA 869

  Fly   686 HRHKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAE 750
            ||||||||||||::||:|.|::.|:::||.:|.      |...|:.....:||....:|..:.:|
Human   870 HRHKLCCLRQELVDAFVEHRYLLFMKLAALQLM------QQNASQLETPSSLENGGPSSLESKSE 928

  Fly   751 KPDDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSN---EVQAAEVVKRACAAVGSLK 812
            .|..:|..:|||..   |.||.|:       ::|....:|..:   :.::.||::.||.||||:.
Human   929 DPPGQEAGSEEEGS---SASGLAK-------VKELAETIAADDGTADPRSREVIRNACKAVGSIS 983

  Fly   813 EKEFDFRFNPDVFSPGIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQ 877
            ...||.|||||:||||:|..:..: ..:..||.|:::||.||:..|||..:|:.|.|:..|:||.
Human   984 STAFDIRFNPDIFSPGVRFPESCQ-DEVRDQKQLLKDAAAFLLSCQIPGLVKDCMEHAVLPVDGA 1047

  Fly   878 SLTESLHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLS 939
            :|.|.:...|||:||||||::::.:.|   ::|::.:|.:.|||.|:.|||:.||:|..|...||
Human  1048 TLAEVMRQRGINMRYLGKVLELVLRSPARHQLDHVFKIGIGELITRSAKHIFKTYLQGVELSGLS 1112

  Fly   940 AAISHFLNCLLTNGPVNPAV---SSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSG 1001
            |||||||||.|::.| ||..   :.|...|||      ||.:.::                 ..|
Human  1113 AAISHFLNCFLSSYP-NPVAHLPADELVSKKR------NKRRKNR-----------------PPG 1153

  Fly  1002 SSNSSSASDWTLMTPRSLWQQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQV 1066
            ::::::   |.:|||:.||:.|.:|||.|:|::|:|::::.||..||:.:|:|:|...||.||||
Human  1154 AADNTA---WAVMTPQELWKNICQEAKNYFDFDLECETVDQAVETYGLQKITLLREISLKTGIQV 1215

  Fly  1067 LLREYNFESKHKPTFGDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALN 1131
            ||:||:|:|:|||.|.::|::|:||:|||::|:|:||::|:.:||||:|||..|||.|||:.|||
Human  1216 LLKEYSFDSRHKPAFTEEDVLNIFPVVKHVNPKASDAFHFFQSGQAKVQQGFLKEGCELINEALN 1280

  Fly  1132 LLNNVFGALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLY 1196
            |.|||:||:|.|..:|||:||||.|::||..:||:.||:||:|||||.|.:||:||.||.||:||
Human  1281 LFNNVYGAMHVETCACLRLLARLHYIMGDYAEALSNQQKAVLMSERVMGTEHPNTIQEYMHLALY 1345

  Fly  1197 SFANGHVGMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLK 1261
            .||:..:..:|.|||||||||:|:.||||||:||:|:||.|:||.:.||:|||||:|:||.::.|
Human  1346 CFASSQLSTALSLLYRARYLMLLVFGEDHPEMALLDNNIGLVLHGVMEYDLSLRFLENALAVSTK 1410

  Fly  1262 YFGDKDMHVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQA 1326
            |.|.|.:.||||:||:||......:|||||.:|||.|:.||:||||:||||::|:|.|:.|||||
Human  1411 YHGPKALKVALSHHLVARVYESKAEFRSALQHEKEGYTIYKTQLGEDHEKTKESSEYLKCLTQQA 1475

  Fly  1327 VLLQRKMNDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFK 1391
            |.|||.||:||.:|. ::::||:..|.|||.|||:.||.||||||:.:|:||:..:::|:.:.
Human  1476 VALQRTMNEIYRNGS-SANIPPLKFTAPSMASVLEQLNVINGILFIPLSQKDLENLKAEVARR-- 1537

  Fly  1392 TDSTENEVNDAINSIVAAANNNGEAEDAVSK---------DIKEQPEAGK 1432
                        :.:..|:.|...||:.::.         |:..||.|.|
Human  1538 ------------HQLQEASRNRDRAEEPMATEPAPAGAPGDLGSQPPAAK 1575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	163..232	CDD:464466	50/68 (74%)
		GSKIP_dom	<324..387	CDD:398795	34/62 (55%)
		CLU	445..665	CDD:463814	187/219 (85%)
		eIF3_p135	870..1073	CDD:463717	81/208 (39%)
		FxSxx_TPR	<1117..1309	CDD:468560	114/191 (60%)
		TPR repeat	1190..1215	CDD:276809	13/24 (54%)
		TPR repeat	1228..1258	CDD:276809	18/29 (62%)
CLUH	XP_054171574.1	PHA03307	114..>307	CDD:223039	30/151 (20%)
		CLU_N	339..412	CDD:464466	51/72 (71%)
		CLU	629..849	CDD:463814	187/219 (85%)
		eIF3_p135	1041..1222	CDD:463717	81/207 (39%)
		FxSxx_TPR	<1273..1458	CDD:468560	110/184 (60%)
		TPR repeat	1296..1322	CDD:276809	15/25 (60%)
		TPR repeat	1335..1365	CDD:276809	17/29 (59%)
		TPR repeat	1378..1406	CDD:276809	17/27 (63%)