DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and LOC100150676

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	XP_001920829.3	Gene:	LOC100150676 / 100150676	-ID:	-	Length:	1658	Species:	Danio rerio

Alignment Length:	1353	Identity:	645/1353 - (47%)
Similarity:	891/1353 - (65%)	Gaps:	112/1353 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TEPTTEAVLSNGHAEKPT------VVD----------AVEDNADTNANV-EKPQEGGAPDAEADG 128
            :|.||.||......|..|      |||          |...:..|:.|| :.|.||.|....|..
Zfish   362 SEQTTLAVTQVERKEDQTERFTLFVVDKLFLATPNFTASSPDTMTSGNVLDGPAEGTAEQVSAVP 426

  Fly   129 DDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLDNVTLDN 193
               |:|..:|.|.||.|.:||.:....|:|.:..||||.|:|||:|||..||||||||:.|||||
Zfish   427 ---DIDPCEDAGFTVKIQAPGTEPRDFQVSPLATVQEIKQVLMDQEETSRRTCFSLQLNGVTLDN 488

  Fly   194 FAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYLNTITQG 258
            |..|:||.:|::||.:.||||||::||.|:|:.|:|:|||:||..|.|||::.:|.::|:.:|:
Zfish   489 FTHLRSIPDLQEGSVLSVVEEPYSVREVRMHLSHIRELLKSLDLTDGYNGVEGSSPSFLSCVTE- 552

  Fly   259 DLLD---KKRTRPD---SVDCTPPEYVTPGVSDPPILPLHPNVKNAKGPQALKVLTTSAWNPPPG 317
            ::::   |.:.|.|   .::|.||:::.||..:..::||.|:....|..:.||||.:|:||||||
Zfish   553 EIMEESSKPKRRGDGMKQINCCPPDHLLPGCKERLLVPLQPHSAFGKSSECLKVLASSSWNPPPG 617

  Fly   318 PRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSLIDLLSHISPSF 382
            .||:|||||||.||||||:.|.|:|.::||||||||..:|||||.:||.|||:|:|||:.|||.|
Zfish   618 NRKMHGDLMYLNVVTMEDRHFSITASTRGFFINQSTTYSFNPKPADPSFLSHALLDLLTQISPVF 682

  Fly   383 RRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYEEHIPGQTRDWN 447
            ::.|..:.|:|...|.|||:|||:||:.|.||.|:||:|.:||||..|.:||||||:|.|.||||
Zfish   683 KKNFSALLKKRGSTHPFERIATPFQVFSWTAPALDHTLDCVRAEDVSSFRLGYEEHLPVQARDWN 747

  Fly   448 EELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGEDTKMQMFIWNN 512
            ||||||||||||.:.:||:|:||||||:.|||:|||||||||:||||:.|||.|:.:.|||:|||
Zfish   748 EELQTTRELPRKNVTDRLIRDRAIFKVNSDFVSAATRGAMAVVDGNVMPINPSEEPRQQMFVWNN 812

  Fly   513 IFFSMGFDVRDHYKELGGDAAAFVAPRYDLHGVRVYNAVDIEGLYTLGTVVVDYRGYRVTAQSII 577
            ||||:||||||.|:|||||:||..||..||:||:.|..:|.|.||.:||.|:|||||||||::|:
Zfish   813 IFFSLGFDVRDQYRELGGDSAAHAAPVLDLNGVKAYWVMDQEDLYLIGTAVIDYRGYRVTAKTIM 877

  Fly   578 PGILEREQEQSVVYGSIDFGKTVLSHPKYLELLRQAGKHLKILPHVVLNERDEPVELCSSVECKG 642
            ||||||:|||||||||.||||||:|..:|||||.:..|.|::..|.|||:.|..||||||||.||
Zfish   878 PGILERDQEQSVVYGSTDFGKTVVSDDRYLELLDKPSKKLRVQRHRVLNKDDTTVELCSSVEHKG 942

  Fly   643 IIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHRHKLCCLRQELLEAFIEDRHV 707
            |:||||||||||||.|||||:|||.::...|:.....:|||..|.|:|.|||||||:||:|.|:.
Zfish   943 IVGNDGRHYILDLLFTFPPDLNFLHVEGEHLNPVCQQLGFPRLHPHRLVCLRQELLDAFVEHRYQ 1007

  Fly   708 NFIRIAAARLQQLTTIKQSE-----KSEANPVPALEGAEAASKVNGAEKPDDKEKKNEEEEKKER 767
            .|::..:........|.||:     ||:.:..|.|       .:|....|:.|.|:..:....::
Zfish  1008 MFMKTVSQSSDDDRRISQSDGTSVIKSDLSTAPQL-------PLNTVRIPEQKPKQPHQITNIQQ 1065

  Fly   768 STSGEARAAAIVNAIREAQSNVATSNEVQAAEVVKRACAAVGSLKEKEFDFRFNPDVFSPGIRHA 832
            |:|           |::..|::..:                       ||.:|||:||.||:|..
Zfish  1066 SSS-----------IKQIFSSLRNT-----------------------FDLQFNPNVFCPGVRFP 1096

  Fly   833 DGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTESLHSHGINVRYLGKVI 897
            . |....:.|||..:::||.||:..|||||:|..:.|:|.|.||.:|||:||.||||:||||.|:
Zfish  1097 K-ESTEEIQKQKQQLKDAASFLISYQIPAFMKNCLEHTSMPTDGVTLTEALHQHGINIRYLGTVL 1160

  Fly   898 KILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISHFLNCLLTN----GPV 955
            :.:.::|   |:|:::|||:.|||.|..||::.||:...||..|||::||||||.|::    |.:
Zfish  1161 EYIEEIPLKERLDHVYRIALCELITRCAKHLFKTYLLAVEPSALSASVSHFLNCFLSSFADAGVI 1225

  Fly   956 NPAVSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSASDWTLMTPRSLW 1020
            ..  |...|.::|   .:..:.:.|:||                       :.:.|:.:||..||
Zfish  1226 QQ--SDRLASRRR---SRRRRSQVSEGG-----------------------TVTIWSTLTPSDLW 1262

  Fly  1021 QQIRKEAKVYWDWELDCDSIETAVSKYGILRISLMRAFCLKVGIQVLLREYNFESKHKPTFGDDD 1085
            :.|..||..|:.:.|.|.|:|.||.|..:.||:|:|...:|.|||:|||||.|:|.....|.::|
Zfish  1263 RAISTEALEYYHYCLCCVSVEEAVDKCRLQRITLLRETAIKTGIQILLREYQFDSGQNVVFTEED 1327

  Fly  1086 IVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFGALHQENGSCLRM 1150
            |:|:||:||||||||:||......||.|:|||..|||.|||..||.|..||:|||||:...|||:
Zfish  1328 ILNIFPVVKHISPRASDALYLLHRGQMKVQQGCLKEGCELICQALALFTNVYGALHQDVCVCLRL 1392

  Fly  1151 LARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHVGMSLKLLYRARY 1215
            |.|:.|:||:..:||:.|||||::||||.|::|||||.||..|.||.||.|....:|:|||||||
Zfish  1393 LGRIHYILGEYAEALSHQQRAVLISERVLGIEHPSTIQEYRLLGLYCFAGGQTVTALRLLYRARY 1457

  Fly  1216 LMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDMHVALSYHLMART 1280
            ||:|:|||||||:||:||.|.|:||::...||:|:|:|:||.|..||.|...:.:|.|:||:|:.
Zfish  1458 LMLLVCGEDHPEMALLDSKIGLVLHSMMACELALKFLENALLLTSKYQGPSSLKLAQSHHLLAKV 1522

  Fly  1281 QSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKMNDIYSSGKLTSD 1345
            ....||||.||.:|||.|..||.|:||.||||::|:|.|:.||.|||:||:.||.||.:|..| :
Zfish  1523 YESKGDFRVALKHEKERYGIYKKQVGEAHEKTQESSEYLKHLTHQAVILQKTMNWIYKTGSDT-N 1586

  Fly  1346 LPPIHITPPSMGSVLDMLNTINGILFVKISRKDIVKVRSEIEKHFKTDSTENE 1398
            :.|:::..||...:::.||.:.||:.:.:|..|:.|:|:..:|  .:..|:|:
Zfish  1587 ISPLNLNSPSRVWIVEQLNLVTGIVLIPLSNSDLEKLRTGAQK--TSQLTQNQ 1637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	43/72 (60%)
		DUF727	<324..387	CDD:283065	40/62 (65%)
		CLU	445..665	CDD:289977	154/219 (70%)
		eIF3_p135	872..1073	CDD:289571	79/207 (38%)
		TPR_12	1098..1177	CDD:290160	43/78 (55%)
		TPR_10	1146..1184	CDD:290111	20/37 (54%)
		TPR_12	1183..1261	CDD:290160	47/77 (61%)
		TPR repeat	1190..1215	CDD:276809	13/24 (54%)
		TPR_12	1225..1303	CDD:290160	38/77 (49%)
		TPR repeat	1228..1258	CDD:276809	15/29 (52%)
LOC100150676	XP_001920829.3	CLU_N	454..527	CDD:291703	43/72 (60%)
		CLU	745..965	CDD:289977	154/219 (70%)
		eIF3_p135	1135..1315	CDD:289571	79/207 (38%)
		TPR_12	1345..1414	CDD:290160	36/68 (53%)
		TPR repeat	1345..1373	CDD:276809	14/27 (52%)
		TPR repeat	1378..1416	CDD:276809	21/37 (57%)
		TPR_12	1383..1455	CDD:290160	39/71 (55%)
		TPR_10	1389..1426	CDD:290111	20/36 (56%)
		TPR repeat	1429..1455	CDD:276809	13/25 (52%)
		TPR_12	1467..1545	CDD:290160	38/77 (49%)
		TPR repeat	1470..1500	CDD:276809	15/29 (52%)
		TPR repeat	1513..1538	CDD:276809	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582780
Domainoid	1	1.000	149	1.000	Domainoid score	I4388
eggNOG	1	0.900	-	-		E1_KOG1839
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54861
OrthoDB	1	1.010	-	-		D48405at33208
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102505
Panther	1	1.100	-	-	O	PTHR12601
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R213
SonicParanoid	1	1.000	-	-		X1595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.750