Protein Alignment clu and si:ch211-166a6.5

DIOPT Version :10

• Sequence 1: NP_611095.1
• Gene: clu / 36793
• FlyBaseID: FBgn0034087
• Length: 1448
• Species: Drosophila melanogaster
• Sequence 2: XP_073766979.1
• Gene: si:ch211-166a6.5 / 100000230
• ZFINID: ZDB-GENE-030131-9913
• Length: 1394
• Species: Danio rerio
• Alignment Length: 1417
• Identity: 468/1417 - (33%)
• Similarity: 747/1417 - (52%)
• Gaps: 188/1417 - (13%)

  Fly    58 GNGTAADGPAAKKKGKKNRNKSPTEPTTEAVLSNGHAEKPTVVDAVEDNADTNANVEKPQEGGAP 122
            |:.|....|:.:.| .::|.|:..:...:....||            |..:.|.:|.....|...
Zfish    55 GSVTPDSTPSTRHK-TQDRQKAAADTMRDTAKKNG------------DRRNNNTDVSCSANGRGI 106

  Fly   123 DAEADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLD 187
            ..|.||           ...|.|...|.:...:|:....|||:....::.|||...|:..:|.|.
Zfish   107 KKEDDG-----------SFPVKIQGAGVEPFELQVHGFWLVQDAIMSVLGREEVAPRSSVALALS 160

  Fly   188 NVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYL 252
            .||||...||:.|...:.|.|:::|||||:.|.|:.|:..|::|||...|.||.  ::..|...|
Zfish   161 GVTLDPMMELQDIKGFKAGVTLRLVEEPYSPRSAQAHLARVQELLKAAGPQDAL--LEGRSPAVL 223

  Fly   253 NTITQGD-----LLDK-KRTRPDSVDCT----PPEYVTPGVSD-PPILPLHPNVKNAKGPQALKV 306
            ||:||..     |..| :||...:...|    ||.|:.||||: ||:..|.|...:::.|..|..
Zfish   224 NTLTQTSEAPPTLHSKNRRTNSKTEQSTEAPPPPTYILPGVSEVPPLTTLLPTNTHSEAPSYLLD 288

  Fly   307 LTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSL 371
            |:.|.||||||.|||.||..|:.|.|:|.|:..|::|.:||::|:||.|.|:|:|...:.:.|.|
Zfish   289 LSLSCWNPPPGFRKLQGDFFYISVHTLEGKQCDITSCPRGFYLNRSTLDVFDPRPAQSTPVCHCL 353

  Fly   372 IDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYE 436
            .||||||||.|:....|::.|.:: ...|.:.|||:...|......|:     .:.:||.:||.:
Zfish   354 TDLLSHISPQFKHTLSTLRHRPSL-PVEESLPTPYRTLSWLGFSSPHS-----HKSSFSGRLGLD 412

  Fly   437 EHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGE 501
            :.:..|..|||:|||..|:||:::|.|||.|:||:.:|:|.||.|..:.|..||||.|..:|..:
Zfish   413 QDLNSQAPDWNKELQAARDLPQRSLEERLTRDRALLQVNGAFVWAVAQAAEKVIDGFVDPVNGSQ 477

  Fly   502 DTKMQMFIWNNIFFSMGFDVRDHYKE-LGGDAAAFVAPRYDLHGVRVYNAV--DIEGLYTLGTVV 563
            :.  ..|:...:|.||..    |.:| |||:.....|.|.:|..|:.|:.:  |::.|:|:.|.:
Zfish   478 ED--PAFLCGGVFMSMPV----HREEWLGGERGHRAAQRLELRCVQAYSDLDADLQKLHTIPTAL 536

  Fly   564 VDYRGYRVTAQSIIPGILEREQEQ---SVVYGSIDFGKTVLSHP---KYLELLRQAGKHLKILPH 622
            .:|||.|::||.:.||:...|..:   .::||   |....|.:|   |.||||.|:.|.|.:..|
Zfish   537 AEYRGVRLSAQGLAPGLQGPETAEVPNGLLYG---FTAGPLENPSRRKLLELLAQSAKALSLQRH 598

  Fly   623 VVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHR 687
            .|:......:.|.:||:.:||:|.|||:|:||:.||.|.|.|| :::|.. ..:..:..||..:.
Zfish   599 AVVGSTGHQLPLFTSVDAQGILGADGRYYLLDVYRTMPADANF-QVEDGG-EADTKEKSFPRRYP 661

  Fly   688 HKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAEKP 752
            |.||.||.||::|||:.:|..|.:...|.|::                           ||.
Zfish   662 HVLCRLRPELVKAFIQHKHAQFTQRVKAHLEE---------------------------NGG--- 696

  Fly   753 DDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSNEVQAAEVVKRACAAVGSLKEKEFD 817
                                            .:..:.| ::..:.:.|::||..|||:.:..|:
Zfish   697 --------------------------------LEDGMQT-DDSHSIDAVRKACKDVGSVSDIIFE 728

  Fly   818 FRFNPDVFSPGIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTES 882
            .||||:|||||::. ...|..|:..||.|::|||.|::..|||||:.:.:..|..|:||.||.::
Zfish   729 MRFNPNVFSPGVQF-PSSESDSVELQKKLLKEAASFIIHNQIPAFMNDCIQSSDVPMDGASLRQA 792

  Fly   883 LHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISH 944
            ||..|||:||||.:|..:||..   ::.::.|:|..|::||..:..:..|:|..|..:||||:||
Zfish   793 LHQKGINLRYLGHLISSISQSDFKHQLRHIKRLAFAEIVVRCAQRFFSGYIQGVETSNLSAAVSH 857

  Fly   945 FLNCLLTNGPVNPAVSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSAS 1009
            ||.|||.            .|....:.|:.:|.:|.:.|:|             .:|:::|::
Zfish   858 FLCCLLV------------PHFSSASNGEESKKRSRRRGRG-------------GAGATDSAA-- 895

  Fly  1010 DWTLMTPRSLWQQIRKEAKVYWDWELDCDS-IETAVSKYGILRISLMRAFCLKVGIQVLLREYNF 1073
             |..::...||..|.::|:..:.::....| ::..|.:||:.::||:|..|||.|||:.||||.|
Zfish   896 -WNALSGNELWSLICQDAQETYRFKEGLGSNVDHLVEQYGLQKMSLLREMCLKTGIQLRLREYAF 959

  Fly  1074 ESKHKPTFGDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFG 1138
            :|::|.....||::||.|:||||:...:||...:...|..:|:||.::.||.:..|..|.:.|..
Zfish   960 DSRNKAPISPDDVLNVLPVVKHITMTTSDATRMFMAAQNSLQKGLLEKAYEQLKEASYLFSRVCD 1024

  Fly  1139 ALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHV 1203
            .||.|...||.:||:::|:.|...:|.::|.|.||:||||.|.|||:||.:|..|::|.:|.|..
Zfish  1025 DLHPEACHCLSLLAKVAYVQGHPAEARSVQLRVVIISERVLGFDHPNTIQQYVLLAVYLYAGGEA 1089

  Fly  1204 GMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDM 1268
            .::.:.||||:.|::.|.|.|||..|:||:::.|:|..    |.||:|:::|||::..:.||.|:
Zfish  1090 ALAQRCLYRAKVLLLTIHGGDHPYTAVIDASLGLMLQG----EQSLQFLQNALKISQSFRGDADL 1150

  Fly  1269 HVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKM 1333
            ..||.:||:|:.....||:|.::|:|||.:|.::::.||:|.:|:.|::.||.:|||||.::|
Zfish  1151 TTALIHHLLAQRLCVSGDYRQSMNHEKEAHSIFQNKCGEDHPQTKCSSDFLRNITQQAVRVER-- 1213

  Fly  1334 NDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDI--------VKVRSEIEKHF 1390
             .|...|...|:.||..:. ||..:.|:.|..:||||....|.:.:        .|...|.||..
Zfish  1214 -SIRQGGAEASETPPEGLF-PSQDTTLEQLALVNGILKTSYSTRMMEFKEKLKEKKAAEEAEKTK 1276

  Fly  1391 KTDSTENEVNDAINSIVAAANNNGEAEDAVSKDIKEQPEAGKQL-TNGDKAA 1441
            :..:.||:.::       .:.|.|||.|.     :||.....:. |.||:|:
Zfish  1277 QESANENQASE-------PSANKGEATDD-----REQANGNAECQTTGDEAS 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	163..232	CDD:464466	26/68 (38%)
		GSKIP_dom	<324..387	CDD:398795	28/62 (45%)
		CLU	445..665	CDD:463814	86/228 (38%)
		eIF3_p135	870..1073	CDD:463717	67/206 (33%)
		FxSxx_TPR	<1117..1309	CDD:468560	76/191 (40%)
		TPR repeat	1190..1215	CDD:276809	9/24 (38%)
		TPR repeat	1228..1258	CDD:276809	11/29 (38%)
si:ch211-166a6.5	XP_073766979.1	None