DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clu and si:ch211-166a6.5

DIOPT Version :9

Sequence 1:	NP_611095.1	Gene:	clu / 36793	FlyBaseID:	FBgn0034087	Length:	1448	Species:	Drosophila melanogaster
Sequence 2:	XP_021334218.1	Gene:	si:ch211-166a6.5 / 100000230	ZFINID:	ZDB-GENE-030131-9913	Length:	1454	Species:	Danio rerio

Alignment Length:	1417	Identity:	468/1417 - (33%)
Similarity:	747/1417 - (52%)	Gaps:	188/1417 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 GNGTAADGPAAKKKGKKNRNKSPTEPTTEAVLSNGHAEKPTVVDAVEDNADTNANVEKPQEGGAP 122
            |:.|....|:.:.| .::|.|:..:...:....||            |..:.|.:|.....|...
Zfish   115 GSVTPDSTPSTRHK-TQDRQKAAADTMRDTAKKNG------------DRRNNNTDVSCSANGRGI 166

  Fly   123 DAEADGDDIDLDALQDIGITVNISSPGADLLCVQLSSMELVQEIHQLLMDREETCHRTCFSLQLD 187
            ..|.||           ...|.|...|.:...:|:....|||:....::.|||...|:..:|.|.
Zfish   167 KKEDDG-----------SFPVKIQGAGVEPFELQVHGFWLVQDAIMSVLGREEVAPRSSVALALS 220

  Fly   188 NVTLDNFAELKSINNLEQGSTIKVVEEPYTMREARIHVRHVRDLLKNLDPADAYNGIDCTSLTYL 252
            .||||...||:.|...:.|.|:::|||||:.|.|:.|:..|::|||...|.||.  ::..|...|
Zfish   221 GVTLDPMMELQDIKGFKAGVTLRLVEEPYSPRSAQAHLARVQELLKAAGPQDAL--LEGRSPAVL 283

  Fly   253 NTITQGD-----LLDK-KRTRPDSVDCT----PPEYVTPGVSD-PPILPLHPNVKNAKGPQALKV 306
            ||:||..     |..| :||...:...|    ||.|:.||||: ||:..|.|...:::.|..|..
Zfish   284 NTLTQTSEAPPTLHSKNRRTNSKTEQSTEAPPPPTYILPGVSEVPPLTTLLPTNTHSEAPSYLLD 348

  Fly   307 LTTSAWNPPPGPRKLHGDLMYLYVVTMEDKRFHISACSKGFFINQSTDDTFNPKPDNPSHLSHSL 371
            |:.|.||||||.|||.||..|:.|.|:|.|:..|::|.:||::|:||.|.|:|:|...:.:.|.|
Zfish   349 LSLSCWNPPPGFRKLQGDFFYISVHTLEGKQCDITSCPRGFYLNRSTLDVFDPRPAQSTPVCHCL 413

  Fly   372 IDLLSHISPSFRRAFQTIQKRRTMRHAFERVATPYQVYQWAAPILEHTVDAIRAEDAFSSKLGYE 436
            .||||||||.|:....|::.|.:: ...|.:.|||:...|......|:     .:.:||.:||.:
Zfish   414 TDLLSHISPQFKHTLSTLRHRPSL-PVEESLPTPYRTLSWLGFSSPHS-----HKSSFSGRLGLD 472

  Fly   437 EHIPGQTRDWNEELQTTRELPRKTLPERLLRERAIFKVHGDFVTAATRGAMAVIDGNVLAINPGE 501
            :.:..|..|||:|||..|:||:::|.|||.|:||:.:|:|.||.|..:.|..||||.|..:|..:
Zfish   473 QDLNSQAPDWNKELQAARDLPQRSLEERLTRDRALLQVNGAFVWAVAQAAEKVIDGFVDPVNGSQ 537

  Fly   502 DTKMQMFIWNNIFFSMGFDVRDHYKE-LGGDAAAFVAPRYDLHGVRVYNAV--DIEGLYTLGTVV 563
            :.  ..|:...:|.||..    |.:| |||:.....|.|.:|..|:.|:.:  |::.|:|:.|.:
Zfish   538 ED--PAFLCGGVFMSMPV----HREEWLGGERGHRAAQRLELRCVQAYSDLDADLQKLHTIPTAL 596

  Fly   564 VDYRGYRVTAQSIIPGILEREQEQ---SVVYGSIDFGKTVLSHP---KYLELLRQAGKHLKILPH 622
            .:|||.|::||.:.||:...|..:   .::||   |....|.:|   |.||||.|:.|.|.:..|
Zfish   597 AEYRGVRLSAQGLAPGLQGPETAEVPNGLLYG---FTAGPLENPSRRKLLELLAQSAKALSLQRH 658

  Fly   623 VVLNERDEPVELCSSVECKGIIGNDGRHYILDLLRTFPPDVNFLKLQDVQLSKELVDMGFPIEHR 687
            .|:......:.|.:||:.:||:|.|||:|:||:.||.|.|.|| :::|.. ..:..:..||..:.
Zfish   659 AVVGSTGHQLPLFTSVDAQGILGADGRYYLLDVYRTMPADANF-QVEDGG-EADTKEKSFPRRYP 721

  Fly   688 HKLCCLRQELLEAFIEDRHVNFIRIAAARLQQLTTIKQSEKSEANPVPALEGAEAASKVNGAEKP 752
            |.||.||.||::|||:.:|..|.:...|.|::                           ||.
Zfish   722 HVLCRLRPELVKAFIQHKHAQFTQRVKAHLEE---------------------------NGG--- 756

  Fly   753 DDKEKKNEEEEKKERSTSGEARAAAIVNAIREAQSNVATSNEVQAAEVVKRACAAVGSLKEKEFD 817
                                            .:..:.| ::..:.:.|::||..|||:.:..|:
Zfish   757 --------------------------------LEDGMQT-DDSHSIDAVRKACKDVGSVSDIIFE 788

  Fly   818 FRFNPDVFSPGIRHADGEEGTSLAKQKVLVQEAAEFLVLKQIPAFIKEHMSHSSSPIDGQSLTES 882
            .||||:|||||::. ...|..|:..||.|::|||.|::..|||||:.:.:..|..|:||.||.::
Zfish   789 MRFNPNVFSPGVQF-PSSESDSVELQKKLLKEAASFIIHNQIPAFMNDCIQSSDVPMDGASLRQA 852

  Fly   883 LHSHGINVRYLGKVIKILSQMP---RMDYLHRIAVLELIVRATKHIYYTYMQNTEPLHLSAAISH 944
            ||..|||:||||.:|..:||..   ::.::.|:|..|::||..:..:..|:|..|..:||||:||
Zfish   853 LHQKGINLRYLGHLISSISQSDFKHQLRHIKRLAFAEIVVRCAQRFFSGYIQGVETSNLSAAVSH 917

  Fly   945 FLNCLLTNGPVNPAVSSEEAHKKRGNGGKHNKHKSSKGGKGQQQQQTTGNQNGSSSGSSNSSSAS 1009
            ||.|||.            .|....:.|:.:|.:|.:.|:|             .:|:::|::
Zfish   918 FLCCLLV------------PHFSSASNGEESKKRSRRRGRG-------------GAGATDSAA-- 955

  Fly  1010 DWTLMTPRSLWQQIRKEAKVYWDWELDCDS-IETAVSKYGILRISLMRAFCLKVGIQVLLREYNF 1073
             |..::...||..|.::|:..:.::....| ::..|.:||:.::||:|..|||.|||:.||||.|
Zfish   956 -WNALSGNELWSLICQDAQETYRFKEGLGSNVDHLVEQYGLQKMSLLREMCLKTGIQLRLREYAF 1019

  Fly  1074 ESKHKPTFGDDDIVNVFPIVKHISPRATDAYNFYTTGQAKIQQGLFKEGYELISGALNLLNNVFG 1138
            :|::|.....||::||.|:||||:...:||...:...|..:|:||.::.||.:..|..|.:.|..
Zfish  1020 DSRNKAPISPDDVLNVLPVVKHITMTTSDATRMFMAAQNSLQKGLLEKAYEQLKEASYLFSRVCD 1084

  Fly  1139 ALHQENGSCLRMLARLSYLLGDAQDALAIQQRAVIMSERVNGMDHPSTILEYTHLSLYSFANGHV 1203
            .||.|...||.:||:::|:.|...:|.::|.|.||:||||.|.|||:||.:|..|::|.:|.|..
Zfish  1085 DLHPEACHCLSLLAKVAYVQGHPAEARSVQLRVVIISERVLGFDHPNTIQQYVLLAVYLYAGGEA 1149

  Fly  1204 GMSLKLLYRARYLMVLICGEDHPEVALIDSNISLILHALGEYELSLRFIEHALKLNLKYFGDKDM 1268
            .::.:.||||:.|::.|.|.|||..|:||:::.|:|..    |.||:|:::|||::..:.||.|:
Zfish  1150 ALAQRCLYRAKVLLLTIHGGDHPYTAVIDASLGLMLQG----EQSLQFLQNALKISQSFRGDADL 1210

  Fly  1269 HVALSYHLMARTQSCMGDFRSALNNEKETYSFYKSQLGENHEKTRDSAECLRLLTQQAVLLQRKM 1333
            ..||.:||:|:.....||:|.::|:|||.:|.::::.||:|.:|:.|::.||.:|||||.::|
Zfish  1211 TTALIHHLLAQRLCVSGDYRQSMNHEKEAHSIFQNKCGEDHPQTKCSSDFLRNITQQAVRVER-- 1273

  Fly  1334 NDIYSSGKLTSDLPPIHITPPSMGSVLDMLNTINGILFVKISRKDI--------VKVRSEIEKHF 1390
             .|...|...|:.||..:. ||..:.|:.|..:||||....|.:.:        .|...|.||..
Zfish  1274 -SIRQGGAEASETPPEGLF-PSQDTTLEQLALVNGILKTSYSTRMMEFKEKLKEKKAAEEAEKTK 1336

  Fly  1391 KTDSTENEVNDAINSIVAAANNNGEAEDAVSKDIKEQPEAGKQL-TNGDKAA 1441
            :..:.||:.::       .:.|.|||.|.     :||.....:. |.||:|:
Zfish  1337 QESANENQASE-------PSANKGEATDD-----REQANGNAECQTTGDEAS 1376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clu	NP_611095.1	CLU_N	159..232	CDD:291703	27/72 (38%)
		DUF727	<324..387	CDD:283065	28/62 (45%)
		CLU	445..665	CDD:289977	86/228 (38%)
		eIF3_p135	872..1073	CDD:289571	66/204 (32%)
		TPR_12	1098..1177	CDD:290160	26/78 (33%)
		TPR_10	1146..1184	CDD:290111	17/37 (46%)
		TPR_12	1183..1261	CDD:290160	31/77 (40%)
		TPR repeat	1190..1215	CDD:276809	9/24 (38%)
		TPR_12	1225..1303	CDD:290160	30/77 (39%)
		TPR repeat	1228..1258	CDD:276809	11/29 (38%)
si:ch211-166a6.5	XP_021334218.1	CLU_N	<224..265	CDD:317460	16/40 (40%)
		CLU	481..701	CDD:315818	86/228 (38%)
		eIF3_p135	842..1019	CDD:315476	66/204 (32%)
		TPR_10	1093..1131	CDD:315939	18/37 (49%)
		TPR_12	1136..1203	CDD:315987	27/70 (39%)
		TPR_12	1173..1245	CDD:315987	28/75 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582781
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1839
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54861
OrthoDB	1	1.010	-	-		D48405at33208
OrthoFinder	1	1.000	-	-		FOG0002136
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102505
Panther	1	1.100	-	-	O	PTHR12601
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.720