Protein Alignment CG8441 and PRKRIP1

DIOPT Version :10

• Sequence 1: NP_611094.1
• Gene: CG8441 / 36792
• FlyBaseID: FBgn0034086
• Length: 253
• Species: Drosophila melanogaster
• Sequence 2: NP_078929.1
• Gene: PRKRIP1 / 79706
• HGNCID: 21894
• Length: 184
• Species: Homo sapiens
• Alignment Length: 171
• Identity: 79/171 - (46%)
• Similarity: 105/171 - (61%)
• Gaps: 28/171 - (16%)

  Fly    34 KPLRP--------FIKTATDLQRLKLEKLMKNPDKPVVIPEQRRE---RDFMSSVPTFVRNVMGS 87
            :|.||        ..|.|.:.|:||||:|||||||.|.|||:..|   |    ..|.|||:||||
Human    10 RPPRPKKEPQTLVIPKNAAEEQKLKLERLMKNPDKAVPIPEKMSEWAPR----PPPEFVRDVMGS 70

  Fly    88 SAGAGSGEFHVYRHLRRKEYARQKNIQNQSAREAADEAYQQKLDDNRRAAEEKTAKKRAKRLKRK 152
            |||||||||||||||||:||.||..:...:.::..|..:|::|:.|:.||||:|||:|.||.|.|
Human    71 SAGAGSGEFHVYRHLRRREYQRQDYMDAMAEKQKLDAEFQKRLEKNKIAAEEQTAKRRKKRQKLK 135

  Fly   153 QR---AKK----------PREDKKPLAKEASEDSNTDSEEE 180
            ::   |||          |.:.|:..:..::|.|.|:.|||
Human   136 EKKLLAKKMKLEQKKQEGPGQPKEQGSSSSAEASGTEEEEE 176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8441	NP_611094.1	DUF1168	58..194	CDD:461977	65/139 (47%)
PRKRIP1	NP_078929.1	Interaction with EIF2AK2. /evidence=ECO:0000250	1..50		19/39 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..76		25/42 (60%)
		DUF1168	42..>125	CDD:461977	46/86 (53%)
		Required for RNA-binding. /evidence=ECO:0000250	51..143		48/95 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..184		22/57 (39%)
		Required for nuclear localization. /evidence=ECO:0000250	126..138		6/11 (55%)