Protein Alignment Lis-1 and daw1

DIOPT Version :10

• Sequence 1: NP_477160.1
• Gene: Lis-1 / 36791
• FlyBaseID: FBgn0015754
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_989349.1
• Gene: daw1 / 394975
• XenbaseID: XB-GENE-5802528
• Length: 415
• Species: Xenopus tropicalis
• Alignment Length: 432
• Identity: 111/432 - (25%)
• Similarity: 192/432 - (44%)
• Gaps: 58/432 - (13%)

  Fly     3 MVLSQRQREELNQAIADYLGSNGYADSLETFRKEADLSTEVEKKFGGLLEKKWTS-----VIRLQ 62
            ::|...:..||.....|.|..:...|        .||..|..:|...|:....|.     ::|||
 Frog    15 IILEYEKGGELKTKAIDLLELSPTTD--------VDLVVEEIQKAEPLITASRTQQVKQLILRLQ 71

  Fly    63 KKVMELEAK-------------------LTEAEKEVIEGAPTKNKRTPGEWIPRPPEKF-SLTGH 107
            :|:.:.:::                   ..::....|.|:   ..||...|.....|:. :|.||
 Frog    72 EKIGQQDSRQFYLFKVLRAHILPLTNVAFNKSGSSFITGS---YDRTCKVWDTASGEELHTLEGH 133

  Fly   108 RASITRVIF-HPIFALMVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSAD 171
            |..:..:.| :|....:.:.|.|.|.::|..|||:...:.:|||..:..:||:.|..|:|:.|.|
 Frog   134 RNVVYAIQFNNPYGDKIATGSFDKTCKLWSAETGKCYHTFRGHTAEIVCLAFNPQSTLIATGSMD 198

  Fly   172 LSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHRE 236
            .:.||||.|...|.: |:.||...:.|::|...||.:::.|.|.|:.:||:.:|..:.|..|||.
 Frog   199 TTAKLWDIQSGEEAL-TLSGHAAEIISLSFNTTGDRLITGSFDHTVSVWEIPSGRRIHTLIGHRG 262

  Fly   237 WVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAAGAD 301
            .:...:.:.:.|:.||.|.|::.::|.:.:..|...|..||..|..:.:
 Frog   263 EISSAQFNWDCSLIATASMDKSCKLWDSLNGKCVATLTGHEDEVLDVTF---------------- 311

  Fly   302 NKKGHHQGPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTIRVW 366
                ...|..:|:.|.|.|.|::..|...||..|.||:..:..:.|:..|..:::||.|||.|:|
 Frog   312 ----DSTGQLVATASADGTARVYSASSRKCLAKLEGHEGEISKICFNAQGNRILTASSDKTSRLW 372

  Fly   367 DLRNKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVW 408
            :.....|::.|..|.....|..|:.....:|:||.|.|.::|
 Frog   373 NPHTGECLQVLKGHTDEIFSCAFNYEGNTIITGSKDNTCRIW 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lis-1	NP_477160.1	LisH	9..40	CDD:128913	6/30 (20%)
		WD40	100..409	CDD:238121	90/311 (29%)
		WD40 repeat	111..148	CDD:293791	9/37 (24%)
		WD40 repeat	154..191	CDD:293791	14/36 (39%)
		WD40 repeat	196..232	CDD:293791	11/35 (31%)
		WD40 repeat	239..274	CDD:293791	7/34 (21%)
		WD40 repeat	280..336	CDD:293791	10/55 (18%)
		WD40 repeat	342..378	CDD:293791	10/35 (29%)
		WD40 repeat	384..408	CDD:293791	7/23 (30%)
daw1	NP_989349.1	WD40	57..415	CDD:441893	100/382 (26%)
		WD 1	90..129		6/41 (15%)
		WD40 repeat	96..132	CDD:293791	7/38 (18%)
		WD 2	132..174		12/41 (29%)
		WD40 repeat	137..175	CDD:293791	9/37 (24%)
		WD 3	175..214		16/39 (41%)
		WD40 repeat	181..217	CDD:293791	14/36 (39%)
		WD 4	217..256		12/38 (32%)
		WD40 repeat	222..258	CDD:293791	11/35 (31%)
		WD 5	259..298		10/38 (26%)
		WD40 repeat	265..300	CDD:293791	7/34 (21%)
		WD 6	301..340		12/58 (21%)
		WD40 repeat	306..342	CDD:293791	10/55 (18%)
		WD 7	343..384		12/40 (30%)
		WD40 repeat	348..384	CDD:293791	10/35 (29%)
		WD 8	386..415		9/29 (31%)
		WD40 repeat	390..414	CDD:293791	7/23 (30%)