DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lis-1 and FBXW11

DIOPT Version :10

Sequence 1:NP_477160.1 Gene:Lis-1 / 36791 FlyBaseID:FBgn0015754 Length:411 Species:Drosophila melanogaster
Sequence 2:NP_001365903.1 Gene:FBXW11 / 23291 HGNCID:13607 Length:563 Species:Homo sapiens


Alignment Length:445 Identity:108/445 - (24%)
Similarity:188/445 - (42%) Gaps:109/445 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 DYLGSN--GYADSLETFRKEADLSTEVEKKFGGLLEKKWTSVI---RLQKKVMELEAKLTEAEKE 78
            |::..|  .|.|:......|             |:.|:|..||   .|.||::|...:.....|.
Human   150 DHIAENILSYLDARSLCAAE-------------LVCKEWQRVISEGMLWKKLIERMVRTDPLWKG 201

  Fly    79 VIEGAP-----TKNKRTPGEWIPRPPEKFSLTGHRASITRVI----------------------- 115
            :.|...     .||:.|.|     ||..|    :|:...::|                       
Human   202 LSERRGWDQYLFKNRPTDG-----PPNSF----YRSLYPKIIQDIETIESNWRCGRHNLQRIQCR 257

  Fly   116 ---FHPIFAL------MVSASEDATIRIWDFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSAD 171
               ...::.|      ::|...|.:|:|||..:.|..:.|.|||.||..:.:|.  :::.:.|:|
Human   258 SENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSD 320

  Fly   172 LSIKLWDFQQSYECIKTMHGHDHNVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCV---KTYTG 233
            .::::||.... |.:.|:..|:..|..:.|  :...:::.|:||:|.:|::|:...:   :...|
Human   321 STVRVWDVNTG-EVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLRRVLVG 382

  Fly   234 HREWVRMVRVHIEGSIFATCSNDQTIRVWLTNSKDCKVELRDHEHTVECIAWAPEAAASAINEAA 298
            ||..|.:  |..:.....:.|.|:||:||.|::.:....|..|:..:.|:               
Human   383 HRAAVNV--VDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACL--------------- 430

  Fly   299 GADNKKGHHQGPFLASGSRDKTIRIWDVSVGLCLLTLSGHDNWVRGLAFHPGGKYLVSASDDKTI 363
                   .::...:.|||.|.|||:||:..|.||..|.||:..||.:.|  ..|.:||.:.|..|
Human   431 -------QYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKI 486

  Fly   364 RVWDLR---------NKRCMKTLYAHQHFCTSIDFHKAHPYVISGSVDQTVKVWE 409
            :||||:         :..|::||..|......:.|.:..  :||.|.|.|:.:|:
Human   487 KVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQ--IISSSHDDTILIWD 539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lis-1NP_477160.1 LisH 9..40 CDD:128913 5/22 (23%)
WD40 100..409 CDD:238121 85/352 (24%)
WD40 repeat 111..148 CDD:293791 10/68 (15%)
WD40 repeat 154..191 CDD:293791 7/36 (19%)
WD40 repeat 196..232 CDD:293791 8/38 (21%)
WD40 repeat 239..274 CDD:293791 8/34 (24%)
WD40 repeat 280..336 CDD:293791 13/55 (24%)
WD40 repeat 342..378 CDD:293791 14/44 (32%)
WD40 repeat 384..408 CDD:293791 6/23 (26%)
FBXW11NP_001365903.1 Beta-TrCP_D 99..137 CDD:463465
F-box_FBXW1B 137..187 CDD:438954 11/49 (22%)
WD40 repeat 264..299 CDD:293791 9/34 (26%)
WD40 <270..539 CDD:441893 81/301 (27%)
WD40 repeat 305..339 CDD:293791 7/36 (19%)
WD40 repeat 344..381 CDD:293791 8/38 (21%)
WD40 repeat 388..421 CDD:293791 8/34 (24%)
WD40 repeat 427..461 CDD:293791 13/55 (24%)
WD40 repeat 467..510 CDD:293791 14/44 (32%)
WD40 repeat 516..538 CDD:293791 6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

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