DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lis-1 and wdr-5.2

DIOPT Version :10

Sequence 1:NP_477160.1 Gene:Lis-1 / 36791 FlyBaseID:FBgn0015754 Length:411 Species:Drosophila melanogaster
Sequence 2:NP_510394.1 Gene:wdr-5.2 / 181540 WormBaseID:WBGene00010572 Length:395 Species:Caenorhabditis elegans


Alignment Length:415 Identity:101/415 - (24%)
Similarity:175/415 - (42%) Gaps:96/415 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    66 MELEAKLTEAEKEVIEGAPTKNK--------------------RTPGEWI--------------- 95
            ||...:.::.|::.|.||.|.::                    .|||..:               
 Worm     1 MEQRGRASQDEEQAIVGAETGSQPSLPVSPMRPIIAPSPAMVLPTPGHGMGIPQFGPVGLPAQAS 65

  Fly    96 -----------------PRP-PEKFSL-----------TGHRASITRVIFHPIFALMVSASEDAT 131
                             |.| |...:|           ..|:.||:.:.|.|....|.|.|.|.:
 Worm    66 TPMLSSTPGPSYSSAPTPMPNPSAANLWPTYKLVAEIPNAHKKSISGIKFSPDGRYMGSGSADCS 130

  Fly   132 IRIW--DFETGEYERSLKGHTDSVQDVAFDAQGKLLASCSADLSIKLWDFQQSYECIKTMHGHDH 194
            |:||  ||   .||::|.||...:.:.::.:..||:.|||.|..:|::|. .|..|:||:.||.:
 Worm   131 IKIWRMDF---VYEKTLMGHRLGINEFSWSSDSKLIVSCSDDKLVKVFDV-SSGRCVKTLKGHTN 191

  Fly   195 NVSSVAFVPAGDYVLSASRDRTIKMWEVATGYCVKTYTGHREWVRMVRVHIEGSIFATCSNDQTI 259
            .|....|.|:|..:.|.|.|.||::|....|..:.:..||.:.|..|..:.:|:..|:.|.|..:
 Worm   192 YVFCCCFNPSGTLIASGSFDETIRIWCARNGNTIFSIPGHEDPVSSVCFNRDGAYLASGSYDGIV 256

  Fly   260 RVWLTNSKDCKVELRDHEH-TVECIAWAPEAAASAINEAAGADNKKGHHQGPFLASGSRDKTIRI 323
            |:|.:.:..|...|.|.|| .:..:.::|                    .|.::.:.:.:.|:::
 Worm   257 RIWDSTTGTCVKTLIDEEHPPITHVKFSP--------------------NGKYILASNLNNTLKL 301

  Fly   324 WDVSVGLCLLTLSGHDNWVRGLAFH---PGGKYLVSASDDKTIRVWDLRNKRCMKTLYAHQHFCT 385
            ||......|...:||:|....:|.:   .|||::||.|:|..:.:|:|:.:..::||..|.....
 Worm   302 WDYQKLRVLKEYTGHENSKYCVAANFSVTGGKWIVSGSEDHKVYIWNLQTREILQTLDGHNTAVM 366

  Fly   386 SIDFHKAHPYVISGSV--DQTVKVW 408
            ..|.|.....:.|.::  |..:|:|
 Worm   367 CTDCHPGQNIIASAALEPDMRIKIW 391

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Lis-1NP_477160.1 LisH 9..40 CDD:128913
WD40 100..409 CDD:238121 88/328 (27%)
WD40 repeat 111..148 CDD:293791 15/38 (39%)
WD40 repeat 154..191 CDD:293791 12/36 (33%)
WD40 repeat 196..232 CDD:293791 11/35 (31%)
WD40 repeat 239..274 CDD:293791 8/34 (24%)
WD40 repeat 280..336 CDD:293791 6/55 (11%)
WD40 repeat 342..378 CDD:293791 11/38 (29%)
WD40 repeat 384..408 CDD:293791 5/25 (20%)
wdr-5.2NP_510394.1 PHA03378 <3..89 CDD:223065 11/85 (13%)
WD40 106..392 CDD:238121 87/310 (28%)
WD40 repeat 110..146 CDD:293791 15/38 (39%)
WD40 repeat 152..188 CDD:293791 12/36 (33%)
WD40 repeat 193..229 CDD:293791 11/35 (31%)
WD40 repeat 236..271 CDD:293791 8/34 (24%)
WD40 repeat 278..314 CDD:293791 6/55 (11%)
WD40 repeat 322..359 CDD:293791 11/36 (31%)
WD40 repeat 365..391 CDD:293791 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

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