Protein Alignment Ptp52F and Ptprv

DIOPT Version :9

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_149090.1
• Gene: Ptprv / 64576
• RGDID: 621123
• Length: 1711
• Species: Rattus norvegicus
• Alignment Length: 1706
• Identity: 368/1706 - (21%)
• Similarity: 605/1706 - (35%)
• Gaps: 567/1706 - (33%)

  Fly    48 VTVVSTVYTLGFSISNEADYSIDKVICRNGSGSETEAN-AAH----------VCENLNPCTFYTS 101
            :.:.:.::..||...::|..|::....|.|.|.....| ::|          |...|..   :..
  Rat     5 ILLAALLWLQGFLAEDDACSSLEGSPDRQGGGPLLSVNVSSHGKSTSLFLSWVAAELGG---FDY 66

  Fly   102 VVSFRS-NVSGKPPPSDQTIYAYT--------------EYKQPKT---------TVTSVVATANT 142
            .:|.|| |.||.  |..|.:.|:|              .|:...|         |:|....||.|
  Rat    67 ALSLRSVNSSGS--PEGQQLQAHTNESGFEFHGLVPGSRYQLKLTVLRPCWQNVTITLTARTAPT 129

  Fly   143 IKVTWQTNDRACVESFGITAK-------ATDYTKSFQ-LLNDKSSQTFVNLSACLTHTITLDTRN 199
            :....|      :.|.|..|:       |.....|:| ||....|||.    ||
  Rat   130 VVRGLQ------LHSAGSPARLEASWSDAPGDQDSYQLLLYHLESQTL----AC----------- 173

  Fly   200 NASVVVDTDATDVDTQYAEPGDLVMNVTNLASGITMITW-GDPSEKNCISNYVFKWQRNDCGTDQ 263
            |.||..||      ..|:. |||:.....:   :.:||| |....|..|    .:|
  Rat   174 NVSVSPDT------LSYSF-GDLLPGTQYV---LEVITWAGSLHAKTSI----LQW--------- 215

  Fly   264 NQDTTTDVPSTETTNEIDYVTTTPMETTPDTPSDEVKCEWTDVSSDGKLREYL-LTDLQGCDLYT 327
                |..||.       |::....:.|:      .::..|.  ||:|....:| ||||.|
  Rat   216 ----TEPVPP-------DHLALRALGTS------SLQAFWN--SSEGATSFHLMLTDLLG----- 256

  Fly   328 FQVFINENSTAKASQ-----TF------TSAEKLVSA------VYEPSPT-----AYPTQLHWT- 369
                 ..|:||...|     ||      |..|..:.|      ::.||.|     :||:.|..|
  Rat   257 -----GTNTTAVIRQGVSTHTFLHLSPGTPHELKICASAGPHQIWGPSATEWTYPSYPSDLVLTP 316

  Fly   370 -----WFSPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEI------ 423
                 |.|.:........|.:.|:||::    .|..:..||..|:|....|.|.|.:::
  Rat   317 LRNELWASWKAGLGARDGYVLKLSGPME----STSTLGPEECNAVFPGPLPPGHYTLQLKVLAGP 377

  Fly   424 ----------------VPNQLNGSA----GTKYQEQS-----TVGEDQPS-------------VI 450
                            :|.::.|:.    |.:..:|.     ...:|.|.             ||
  Rat   378 YDAWVEGSTWLAESAALPREVPGARLWLDGLEASKQPGRRALLYSDDAPGSLGNISVPSGATHVI 442

  Fly   451 QDPVVEAEAYSMEVSWKTPEY------------------------ADLCI---------DGYRLS 482
            ...:|....|.::::..|.:.                        :||.|         :||:::
  Rat   443 FCGLVPGAHYRVDIASSTGDISQSISGYTSPLPPQSLEVISRSSPSDLTIAWGPAPGQLEGYKVT 507

  Fly   483 GWMEDDK------LVEV--EALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVE 539
             |.:|..      ||::  :.||:|.        |:|:....|.:....:. .|||...:::
  Rat   508 -WHQDGSQRSPGDLVDLGPDTLSLTL--------KSLVPGSCYTVSAWAWA-GNLDSDSQKI--- 559

  Fly   540 TKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYNNSC-----PTIFALFTCNATTQVRNPYAERYV 599
                                             :||     ||..:|...:....::   |..|.
  Rat   560 ---------------------------------HSCTRPAPPTNLSLGFAHQPAALK---ASWYH 588

  Fly   600 EGHSKQGFNASLSPLSPYATYVCKVILYNVAGPSEPVVDADMHTTTY--------FPEQPESVML 656
            ....:..|:..|..|.|...            .||.|:..:....::        |..|..::..
  Rat   589 PPGGRDAFHLRLYRLRPLTL------------ESEKVLPREAQNFSWAQLTAGCEFQVQLSTLWG 641

  Fly   657 EKSTVSSLLFNWQPPT-------YTNGP--IKYYQAFLMRHEASYFVPADCAIVEQDTKSETK-- 710
            .:.:.|:....|.||:       .::.|  ::...|.:....:.|.|    .:.::.|::.|.
  Rat   642 SERSSSANATGWTPPSAPTLVNVTSDAPTQLQVSWAHVPGGRSRYQV----TLYQESTRTATSIM 702

  Fly   711 --GDPSVNFTGLAPAVRYMMQV---------AAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLT 764
              .:...:|.||.|..:|.::|         ||.|   :..:|.|:|          ..:|.|..
  Rat   703 GPKEDGTSFLGLTPGTKYKVEVISWAGPLYTAAAN---VSAWTYPLI----------PNELLVSM 754

  Fly   765 QGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYT 829
            |.   .:||    |.:.|  |....|     |.|.:...::...:|:|:.::|      |:..:.
  Rat   755 QA---GSAV----VNLAW--PSGPLG-----QGACHAQLSDAGHLSWEQPLKL------GQELFM 799

  Fly   830 ETEMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAI 894
            ..::.|  .:|:.:||:.|                || |...|..|:.   .:||  ..|.:..:
  Rat   800 LRDLTP--GHTISMSVRCR----------------AG-PLQASTHLVV---LSVE--PGPVEDVL 840

  Fly   895 VRLPADIM----TSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVL--------SYQEA--- 944
            ....|..:    |..:||:....:::.:....|..|..:.|::....:|        ||:.:
  Rat   841 CHPEATYLALNWTMPAGDVDVCLVVVERLVPGGGTHFVFQVNTSGDALLLPNLMPTTSYRLSLTV 905

  Fly   945 ---GADGTGDCSLEYQTTEERWHP----EPVQRQ---------------RRDGEV---------- 977
               .:..:...||...|:.|.|||    ||.|.:               :.||::
  Rat   906 LGRNSRWSRAVSLVCSTSAEAWHPPELAEPPQVELGTGMGVTVMRGMFGKDDGQIQWYGIIATIN 970

  Fly   978 -----TSDEEIVFT-----------------------------------IGLDKCSEVQKTYCNG 1002
                 .|.|.|.:|                                   :|.:.|...|: .|||
  Rat   971 MTLAQPSREAINYTWYDHYYRGCESFLALLFPNPFYPEPWAGPRSWTVPVGTEDCDNTQE-ICNG 1034

  Fly  1003 PLLPDTDYNVVVRLFTASGYSDAAVLNF----KTKAAIKVTLILVSVCSCLLLAFVLG--LTVLW 1061
            .|.....|...|..|:... :...:|.|    :.:|:|.:.:|.::|    :|..|:|  :.|..
  Rat  1035 RLKSGFQYRFSVVAFSRLN-TPETILAFSAFSEPRASISLAIIPLTV----MLGAVVGSIVIVCA 1094

  Fly  1062 VRKRLAWKRDSGQGIE-DPFGNVIAKNFAIFYTEVAKPEKLAREFKEITVVALELSYSASELGCH 1125
            |...|.|:...|...| |.|...:            .|..|.|..:.|.:.:...||.|.....|
  Rat  1095 VLCLLRWRCLKGPRSEKDGFSKEL------------MPYNLWRTHRPIPIHSFRQSYEAKSAHAH 1147

  Fly  1126 -----------------------------KNRYADIFPYDKNRV-ILDIDAE-GSDYINASFIDG 1159
                                         ||||..:.|||.:|| :..:..| .||||||:||.|
  Rat  1148 QTFFQEFEELKEVGKDQPRLEAEHPDNIIKNRYPHVLPYDHSRVRLTQLPGEPHSDYINANFIPG 1212

  Fly  1160 HTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN----VRG-LTV 1219
            ::..:|.||||||..:::.||||::.:..|.||:.:|...|...:.|..|:|.|    ..| :|:
  Rat  1213 YSHTQEIIATQGPLKKTLEDFWRLVWEQQVHVIIMLTVGMENGRVLCEHYWPANSTPVTHGHITI 1277

  Fly  1220 TIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSY- 1283
            .:.::|..:.:.|.|..:.|.....:.:|....|..||||.|||.|..|:.||:.|:.:.:.:.
  Rat  1278 HLLAEEPEDEWTRREFQLQHGTEQKQRRVKQLQFTTWPDHSVPEAPSSLLAFVELVQEQVQATQG 1342

  Fly  1284 -SPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTY 1347
             .||:|||||||||||||:.|..::::|:.|...::|.||..||..|..|:||..||.||::|..
  Rat  1343 KGPILVHCSAGVGRTGTFVALLRLLRQLEEEKVADVFNTVYILRLHRPLMIQTLSQYIFLHSCLL 1407

  Fly  1348 ELVKHKIPRAALKMDGRPKSVTVPAIPSPKKVSFPDVDVGSEY--VSSAPITDLDDGRPIVQLPS 1410
            ..:....|.::   |..|.||...|....|:.:..:.....||  :..|    :.||...: ||
  Rat  1408 NKILEGPPDSS---DSGPISVMDFAQACAKRAANANAGFLKEYKLLKQA----IKDGTGSL-LP- 1463

  Fly  1411 RFSGLRRNSPPGENDN 1426
                     ||..|.|
  Rat  1464 ---------PPDYNQN 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	23/122 (19%)
		PTPc	1100..1345	CDD:214550	97/282 (34%)
		PTPc	1125..1348	CDD:238006	92/260 (35%)
Ptprv	NP_149090.1	fn3	49..109	CDD:278470	13/64 (20%)
		fn3	131..201	CDD:278470	23/100 (23%)
		FN3	473..547	CDD:214495	15/82 (18%)
		FN3	656..>725	CDD:238020	12/72 (17%)
		PTPc	1150..1408	CDD:214550	91/257 (35%)
		PTPc	1177..1408	CDD:238006	91/230 (40%)
		Substrate binding. /evidence=ECO:0000250	1350..1356		5/5 (100%)
		PTPc	<1521..1693	CDD:304379

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810