DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptp52F and PTPRS

DIOPT Version :10

Sequence 1:NP_611093.2 Gene:Ptp52F / 36790 FlyBaseID:FBgn0034085 Length:1433 Species:Drosophila melanogaster
Sequence 2:NP_002841.3 Gene:PTPRS / 5802 HGNCID:9681 Length:1948 Species:Homo sapiens


Alignment Length:1531 Identity:358/1531 - (23%)
Similarity:557/1531 - (36%) Gaps:446/1531 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 SESQELAEKVEVTVVSTVYTLGFSISNEADYSIDKVICRNGSGSETEANAAHVCENLNPCTFYTS 101
            |:||:...:::..:.:|.|::| .:|..::|.|                             :.|
Human   369 SKSQDGPYQIKEDITTTRYSIG-GLSPNSEYEI-----------------------------WVS 403

  Fly   102 VVSFRSNVSGKPPPSDQTIYAYTEYKQPKTTVTSVVA---TANTIKVTWQTNDRACVESFGI--- 160
            .|    |..|:.||| :::...|..:.|.:...:|.|   :|.|:.|.|:..    ||..|:   
Human   404 AV----NSIGQGPPS-ESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEP----VEPNGLIRG 459

  Fly   161 -----TAKATDYTKSFQLLN-DKSSQTFV-NLSACLTHTITLDTRNNASVVVDTDATDVDTQYAE 218
                 |.:......::|..| |.|..|.| :|....|:|:.:....:......:|...|.||...
Human   460 YRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGV 524

  Fly   219 PGDLVMNVTNLASGITMIT--WGDPSEKNCISNYVFKWQRNDCGTDQNQ--DTTTDV------PS 273
            ||. .||:...|...|.||  |..|.:::.| .|...::..|.|.:..:  |.||..      |:
Human   525 PGQ-PMNLRAEARSETSITLSWSPPRQESII-KYELLFREGDHGREVGRTFDPTTSYVVEDLKPN 587

  Fly   274 TETTNEI------------DYVTTTPMETTPDTPSDEVKCEWTDVSSDGKLREYLLTDLQGCDLY 326
            ||....:            ..|....:::.|..|..:|||                         
Human   588 TEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKC------------------------- 627

  Fly   327 TFQVFINENSTAKASQTFTSAEKLVSAVYEPSPTAYPTQLHWTWFSPQNHPKCVANYSVTLTGPI 391
                 ::..|||          .|||  :.|.|             |:.|...:..|||... |:
Human   628 -----VSVRSTA----------ILVS--WRPPP-------------PETHNGALVGYSVRYR-PL 661

  Fly   392 --QRSENKTMNVITEETFAI-FDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTV----GEDQPSV 449
              :..|.|.:|.|...|..| .:.|:....|.:..|.:...|..    .|.|.|    .||.||.
Human   662 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPG----PESSPVVVRTDEDVPSA 722

  Fly   450 IQDPVVEAEAY---SMEVSWKTP----EYADLCIDGY-----RLSG------------------W 484
             ....|||||.   ::.|.|::|    ::..  |.||     |:.|                  |
Human   723 -PPRKVEAEALNATAIRVLWRSPAPGRQHGQ--IRGYQVHYVRMEGAEARGPPRIKDVMLADAQW 784

  Fly   485 MEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTK 549
            ..||          |.:...|:  .||.....|.|.:..||.:....:.:...|.||.|::....
Human   785 ETDD----------TAEYEMVI--TNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPT 837

  Fly   550 VKLEMKNAGSEFI-----------DLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHS 603
            :.::....||...           .::.:...:.....|..|       |....|..:||.....
Human   838 LSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLA-------TLEFPPSEDRYTASGV 895

  Fly   604 KQGFNASLSPLSPYATYVCKVILYNVAGPSE---PVVDADMHTTTYFPEQPESVMLEKSTVSSLL 665
            .:|           ||||.::...:..|..|   .|:.....|....|:..|:.  ..::..::|
Human   896 HKG-----------ATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAA--GNASAGTVL 947

  Fly   666 FNWQP--PTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDP----SVNFTGLAPAV 724
            ..|.|  |...||.|..|...:  .||....||      ::|:.....:|    ::...||.|..
Human   948 LRWLPPVPAERNGAIVKYTVAV--REAGALGPA------RETELPAAAEPGAENALTLQGLKPDT 1004

  Fly   725 RYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNA--VYEANVTITWKVPCK 787
            .|.:||.|....|.|.::.||...|.  :.|.|:        |.|...  :.:.:|.::|:.|..
Human  1005 AYDLQVRAHTRRGPGPFSPPVRYRTF--LRDQVS--------PKNFKVKMIMKTSVLLSWEFPDN 1059

  Fly   788 SNGDIEYFQLAFNGTR------------NNFAPVSFERRVELDTGNKQGRMSYTETEM------- 833
            .|....| ::.:||..            .:..|.:|...|..:.|:..|.:..|.|..       
Human  1060 YNSPTPY-KIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLN 1123

  Fly   834 -------QPQFDYTVEVSVKNRD-----------VEQLSSSVPGSWQSPAGLP-TIPSDELIK-- 877
                   :|..|..:.|.:.:..           :..|..|..|.:.:|.|.| .:..:|||:  
Human  1124 GKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDI 1188

  Fly   878 ---QMRA--NVEETSNPTKTAIVRLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPK 937
               |.|:  :..:...|......|......|...||.|                           
Human  1189 SRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQK--------------------------- 1226

  Fly   938 VLSYQEAGADGTGDCSLE------------YQTTEERW----HPEPVQRQRRDGE--VTSDEEIV 984
                |..|.|..|   ||            .|.:|..:    ..:|.|....|.:  |..:|.::
Human  1227 ----QYGGFDNRG---LEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEGLI 1284

  Fly   985 FTIG------------------------LDKCSEVQKTYC---NGPLLPDTDYNVVVRLFTASGY 1022
            :.||                        ..|.|| .:|.|   |..|.|....:.|         
Human  1285 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSE-PRTKCLLNNADLAPHHPKDPV--------- 1339

  Fly  1023 SDAAVLNFKTKAAIKVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIED-------PF 1080
             :...:||:|..:                    ||     |..|   |:.|...|.       |.
Human  1340 -EMRRINFQTPDS--------------------GL-----RSPL---REPGFHFESMLSHPPIPI 1375

  Fly  1081 GNVIAKNFAIFYTEVAKPE---KLAREFKEITV-VALELSYSASELGCHKNRYADIFPYDKNRVI 1141
            .::..      :||..|..   ||::|::.|.. ......:|..|:...|||||::..||.:|||
Human  1376 ADMAE------HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVI 1434

  Fly  1142 LD-IDA-EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTI 1204
            |. |:. .|||||||:::||:..:..|||||||.||:..|||||:.:.....||.:|:..|.:.|
Human  1435 LQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRI 1499

  Fly  1205 KCHEYYPYNVRG------LTVTIKSKEVLELYDRTELTVVHDKYGLKEK--VIHYYFKKWPDHGV 1261
            ||.:|:|.  ||      :.||:  .:.:||......|....|.|..||  |..:.|..||||||
Human  1500 KCDQYWPN--RGTETYGFIQVTL--LDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1560

  Fly  1262 PEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLR 1326
            ||.|...:.|:::||....|...||||||||||||||.||.:|.:::|:|.|..::::..|..:|
Human  1561 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1625

  Fly  1327 FQRMKMVQTQQQYTFLYACTYELV---KHKIPRAAL 1359
            .||..||||:.||:|::....|.|   ..::|..:|
Human  1626 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ptp52FNP_611093.2 FN3 648..749 CDD:238020 27/106 (25%)
PTPc 1100..1345 CDD:214550 107/255 (42%)
PTPRSNP_002841.3 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000250|UniProtKB:B0V2N1 68..72
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 137..235 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 199..204 CDD:409400
Ig strand F 213..220 CDD:409400
Ig strand G 223..234 CDD:409400
IgI_3_RPTP_IIa_LAR_like 248..329 CDD:409401
Ig strand A 248..250 CDD:409401
Ig strand A' 254..258 CDD:409401
Ig strand B 261..269 CDD:409401
Ig strand C 274..280 CDD:409401
Ig strand C' 282..284 CDD:409401
Ig strand D 287..291 CDD:409401
Ig strand E 296..301 CDD:409401
Ig strand F 308..315 CDD:409401
FN3 318..>724 CDD:442628 98/456 (21%)
Ig strand G 319..328 CDD:409401
FN3 <671..>981 CDD:442628 74/356 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 700..724 8/28 (29%)
FN3 1037..>1097 CDD:238020 11/60 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1311..1340 9/39 (23%)
R-PTPc-S-1 1370..1651 CDD:350473 113/290 (39%)
R-PTP-S-2 1653..1942 CDD:350475 2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.