Protein Alignment Ptp52F and PTPRO

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Alignment Length: 1505
• Identity: 330/1505 - (21%)
• Similarity: 543/1505 - (36%)
• Gaps: 493/1505 - (32%)

  Fly    13 IHA---LILILWIAGVQGQTVGSLVAVSESQELAEKVEVTVV---STVYTLGFSISNEADYSIDK 71
            ||.   |:.:||:..:........|.|.:...:...:|.:.|   ::||.:  .|:.|:
Human     8 IHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVV--KITGES------ 64

  Fly    72 VICRNGSGSETEANAAHVCENLN-----PCTFYTS---------VVSFRSNVSGKP--------- 113
                        .|.....|..|     |..|..|         :|....||..||
Human    65 ------------KNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTK 117

  Fly   114 --PPSDQTIYAYTEYK-QPKTTVTSVVATANTIKV-------TWQTNDRACVESFGITAKATDYT 168
              |.:..:||   :|| .|:|.|...:.......|       .|:..|..       |....|:.
Human   118 PLPVTSVSIY---DYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFR-------TMLYKDFF 172

  Fly   169 KSFQLLND-KSSQTFVNLSACLTHTITLDTRNNASVVVDTDATDVD-----TQYAEPGDLVMNVT 227
            |...:.|. .....:.|::..|....|.    |.|.:|:......:     |....|.::.:.:.
Human   173 KGKTVFNHWLPGMCYSNITFQLVSEATF----NKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIV 233

  Fly   228 NLASGITMITWGDPSEKNCISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTP 292
            ||...    .|.:.|......:::           ::|||.........|.|           ||
Human   234 NLNKN----NWEEQSGNFPEESFM-----------RSQDTIGKEKLFHFTEE-----------TP 272

  Fly   293 DTPSDEVKCEWTDVSSDGKLREYLLT------DLQGCDLYTFQVFIN------ENSTAKASQTFT 345
            :.||..:...|.|.:|.    :|..|      |.......:...|::      ||::     |.:
Human   273 EIPSGNISSGWPDFNSS----DYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNS-----TLS 328

  Fly   346 SAEKLVSAVYEPSPTAYPTQLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKT-MNVITEETFAI 409
            ..||..|..:    :.:|.|:..||..|: .|.....:.:    .|:|.||.| ..::.||....
Human   329 ETEKSTSGSF----SFFPVQMILTWLPPK-PPTAFDGFHI----HIEREENFTEYLMVDEEAHEF 384

  Fly   410 FDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQPSVIQDPVVEAEAYSMEVSWKTPEYADL 474
            ..:|...|.|.:.:.....:||..|: :.||                |::.|..:|   |
Human   385 VAELKEPGKYKLSVTTFSSSGSCETR-KSQS----------------AKSLSFYIS---P----- 424

  Fly   475 CIDGYRLSG-WMED----DKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLR 534
                   || |:|:    .:.|.|..||.||
Human   425 -------SGEWIEELTEKPQHVSVHVLSSTT---------------------------------- 448

  Fly   535 QVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYV 599
                    |::.:|                 :...:||::..::.:| ||.     :...::|..
Human   449 --------ALMSWT-----------------SSQENYNSTIVSVVSL-TCQ-----KQKESQRLE 482

  Fly   600 EGHSKQGFNAS---LSPLSPYATYVCKVILYNVAG-----PSEPVVDADMHT----TTYFPEQPE 652
            :.:..| .|:|   :..|.|.|.|  :|::|...|     ||:||..|.:.|    ...:|..|.
Human   483 KQYCTQ-VNSSKPIIENLVPGAQY--QVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPT 544

  Fly   653 SVML----------EKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKS 707
            :|:|          .|..|....||  |.|.|:....||:           :.|..::.
Human   545 AVVLSWTRPYLGVFRKYVVEMFYFN--PATMTSEWTTYYE-----------IAATVSLT------ 590

  Fly   708 ETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIG---------ITLPAVSDSVTQLTVL 763
                 .||....|.||..|..:|.      |..:.:|.:.         ||.| |:..:|.:...
Human   591 -----ASVRIANLLPAWYYNFRVT------MVTWGDPELSCCDSSTISFITAP-VAPEITSVEYF 643

  Fly   764 TQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVE---LDTGNKQGR 825
                  |:.:|     |:|     :.||             :...:|..|.:.   :..|.|:.:
Human   644 ------NSLLY-----ISW-----TYGD-------------DTTDLSHSRMLHWMVVAEGKKKIK 679

  Fly   826 MSYTETEMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPT 890
            .|.|...|      |..:|:...|:..||                        :.|..|..||.:
Human   680 KSVTRNVM------TAILSLPPGDIYNLS------------------------VTACTERGSNTS 714

  Fly   891 KTAIVRL----PADIM----TSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGAD 947
            ...:|:|    |..:.    |..|..:.|:.        .||        :|:.:|.. |:.|:.
Human   715 MLRLVKLEPAPPKSLFAVNKTQTSVTLLWVE--------EGV--------ADFFEVFC-QQVGSS 762

  Fly   948 GTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNV 1012
                     |.|:.:   |||       .|:|.   |.||              ..|||.|.||.
Human   763 ---------QKTKLQ---EPV-------AVSSH---VVTI--------------SSLLPATAYNC 791

  Fly  1013 VVRLFTASGYS---DAAVLNFKTKAAIKVTLI-LVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSG 1073
            .|..|:....|   ..||....|:....|.:| ::::.|.||:..:|...::..:|.|...|:.|
Human   792 SVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECG 856

  Fly  1074 QGIEDPFG-------------------------------------NVIAKN-------------- 1087
            .|....|.                                     |..:||
Human   857 AGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLD 921

  Fly  1088 -FAIFYTEVAKPE--KLAREFKEITVVALELSYSASELGCH--KNRYADIFPYDKNRVILDI--D 1145
             |..:..::||..  |.:.:|:|:.::.|::.:.|::|..:  ||||.:|.|||.:||.|..  :
Human   922 DFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNE 986

  Fly  1146 AEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYY 1210
            .||:|||||::|.|:...:||||||||.||:..|||:|:||...::||.:||..|...:||..|:
Human   987 EEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1051

  Fly  1211 PYNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEK---VIHYYFKKWPDHGVP--EDPMHLIM 1270
            |:....:.....:.|::...::.:....|.:....::   |:|:.:..|||||||  .....::.
Human  1052 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQ 1116

  Fly  1271 FVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQT 1335
            ||..|:.:...|..|:::|||||||||||||.||.::|.::....::|...|.::|..||.||||
Human  1117 FVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQT 1181

  Fly  1336 QQQYTFLYAC 1345
            ::||.|::.|
Human  1182 EEQYIFIHQC 1191

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	23/119 (19%)
		PTPc	1100..1345	CDD:214550	95/253 (38%)
PTPRO	NP_109592.1	fn3	435..521	CDD:394996	24/153 (16%)
		FN3	530..630	CDD:238020	24/129 (19%)
		fn3	725..805	CDD:394996	29/132 (22%)
		R-PTPc-O	951..1195	CDD:350462	92/241 (38%)