Protein Alignment Ptp52F and PTPRN

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_002837.1
• Gene: PTPRN / 5798
• HGNCID: 9676
• Length: 979
• Species: Homo sapiens
• Alignment Length: 1055
• Identity: 216/1055 - (20%)
• Similarity: 366/1055 - (34%)
• Gaps: 335/1055 - (31%)

  Fly   506 VFDKNLLA-------------CQVYI------IQIIPYTKENLDGQLRQV---GVETKAAIVDYT 548
            :||:.|.:             |||.:      :|:.....:.|.|.|||:   |:.....:..|.
Human    41 LFDRRLCSHLEVCIQDGLFGQCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYV 105

  Fly   549 KVKLEMKN------------------------AGSEFIDLIAFNADYNNSCPTIFALFTCNATTQ 589
             :..||:.                        ||...:..|.     ..|.|          ..|
Human   106 -ISQEMERIPRLRPPEPRPRDRSGLAPKRPGPAGELLLQDIP-----TGSAP----------AAQ 154

  Fly   590 VRNPYAERYVEGHSKQGFNASLSPLSPYATYVCKVILYNVAGPSEPVVDADMHTTTYFPEQPESV 654
            .|.|...   .|....|.::|||||                       .|::     .|...|.:
Human   155 HRLPQPP---VGKGGAGASSSLSPL-----------------------QAEL-----LPPLLEHL 188

  Fly   655 MLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFTG 719
            :|             ||...:..:.|..|.|..:....|...|.:.|       ::|.|.:...|
Human   189 LL-------------PPQPPHPSLSYEPALLQPYLFHQFGSRDGSRV-------SEGSPGMVSVG 233

  Fly   720 LAP---AVRYMMQVAAQNDFG------MGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNAVYE 775
            ..|   |.....:.|::..||      .|....|     .||.....:.|..|.|
Human   234 PLPKAEAPALFSRTASKGIFGDHPGHSYGDLPGP-----SPAQLFQDSGLLYLAQ---------- 283

  Fly   776 ANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYT 840
                   ::|..|...:.......:.:|...:|..:|:....|.|.|.     ....:||  |..
Human   284 -------ELPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGLGDRGEKP-----ASPAVQP--DAA 334

  Fly   841 VE----------VSVKNRDVEQLSSSV-------PGSWQSPAGLPTIPSDELIKQMRANVE---- 884
            ::          |.::....||||:.:       .|:.::|.|:..:.:| :.|.|...||
Human   335 LQRLAAVLAGYGVELRQLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGAD-IKKTMEGPVEGRDT 398

  Fly   885 -------------ETSNPTKTAIVRLPADIMT----SASGDI------KWMALMISQKNCAGVPH 926
                         .|::||.:.:.::|:.:.:    :|...:      |...|..||...||.|.
Human   399 AELPARTSPMPGHPTASPTSSEVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPS 463

  Fly   927 LKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWH-------------PEPVQRQRRDGEVT 978
            .: ..:.::..:::.|:..:...|...||  ...|..|             |....|.|.:.:..
Human   464 AR-PAAEEYGYIVTDQKPLSLAAGVKLLE--ILAEHVHMSSGSFINISVVGPALTFRIRHNEQNL 525

  Fly   979 SDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFTASGYSD--AAVL-----NFKTKAAI 1036
            |..::....||.| ||::         ..|...:   |.|..|..:  ||||     :.....::
Human   526 SLADVTQQAGLVK-SELE---------AQTGLQI---LQTGVGQREEAAAVLPQTAHSTSPMRSV 577

  Fly  1037 KVTLILVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSGQGIEDPFGNV------------------ 1083
            .:||:.::..:.||:|..:.|.|....::...:|.:..|.|...|:.
Human   578 LLTLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDTTFEYQDLCRQHMATKSLF 642

  Fly  1084 --------------IAKNFA---------------------------------IFYTE--VAKPE 1099
                          ::..|:                                 :.|.|  :...:
Human   643 NRAEGPPEPSRVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRD 707

  Fly  1100 KLAREFKEITVVALELSYSASELG---CHKNRYADIFPYDKNRVILDIDA--EGSDYINAS-FID 1158
            :||:|::.:.....|.:..|:..|   ..|||:.|..|||..|:.|.:::  ..||||||| .|:
Human   708 RLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE 772

  Fly  1159 GHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRGLTVTIKS 1223
            ...|...|||||||...::.|||:|:.:....|||.:|...|....:|..|:|
Human   773 HDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWP------------ 825

  Fly  1224 KEVLELYDRTELTVVHDKYGLKEKVI-----------------HYYFKKWPDHGVPEDPMHLIMF 1271
            .|...||...|:.:|.:....::.::                 .::|..||..|.|.....|:.|
Human   826 DEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDF 890

  Fly  1272 VKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRL-KSESKINIFETVKKLRFQRMKMVQT 1335
            .:||....|....||:||||.|.|||||:|.:|:::.|: |...:|:|..|::.:|.||..:|::
Human   891 RRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRS 955

  Fly  1336 QQQYTFLYACTYELV 1350
            :.|:.|......|.|
Human   956 KDQFEFALTAVAEEV 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	21/109 (19%)
		PTPc	1100..1345	CDD:214550	83/268 (31%)
PTPRN	NP_002837.1	RESP18 homology domain	35..131		16/90 (18%)
		RESP18	60..160	CDD:464394	21/115 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..173		10/78 (13%)
		PHA03247	<234..468	CDD:223021	48/264 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	289..329		7/44 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	393..439		7/45 (16%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000269|PubMed:25561468	449..575		29/141 (21%)
		Receptor_IA-2	469..557	CDD:463293	19/102 (19%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250|UniProtKB:P80560	601..732		12/130 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	643..680		1/36 (3%)
		R-PTP-N	693..973	CDD:350457	87/290 (30%)