Protein Alignment Ptp52F and PTPRJ

DIOPT Version :9

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_016873572.1
• Gene: PTPRJ / 5795
• HGNCID: 9673
• Length: 1363
• Species: Homo sapiens
• Alignment Length: 1472
• Identity: 334/1472 - (22%)
• Similarity: 550/1472 - (37%)
• Gaps: 405/1472 - (27%)

  Fly    69 IDKVICRNGSGSE-TEANAAHVCENLNPCTFYTSVV-SF-RSNVSGKPPPSDQTIYAYTEYKQPK 130
            :.:::|..|:.|. .:.:.|.|....|..|..:|.. || :.|.:|.|              |.:
Human   144 LGQILCAGGTPSPIPDPSVATVATGENGITQISSTAESFHKQNGTGTP--------------QVE 194

  Fly   131 TTVTSVVATANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQTFVNLSACLTHTITL 195
            |. ||....::....:.:|.::....:.|.:.|....|:...:.:.:.:.|.|. .|.|:.:
Human   195 TN-TSEDGESSGANDSLRTPEQGSNGTDGASQKTPSSTEPIPVSDLRVALTGVR-KAALSWS--- 254

  Fly   196 DTRNNASVVVDTDATDVDTQYAEPGDLVMNVTNLASGI----------TMITWGDPSEKNCISNY 250
            :....||..|..::.....:..:...|.:|::.|..|:          :..|.|||
Human   255 NGNGTASCRVLLESIGSHEELTQDSRLQVNISGLKPGVQYNINPYLLQSNKTKGDP--------- 310

  Fly   251 VFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTPDTP-SDEVKCEWTDVSSDGKLR- 313
                    .||:...|.:    :||.:.          ..:|..| .||......|.||..:.|
Human   311 --------LGTEGGLDAS----NTERSR----------AGSPTAPVHDESLVGPVDPSSGQQSRD 353

  Fly   314 -EYLLTDLQGCDLYTFQVFIN-ENST----------AKASQTFTSAEKLVSAVYEPSPTAYPTQL 366
             |.||..|:....|...|:.. .|.|          ..|.|.|......:||          |.|
Human   354 TEVLLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVFDVTAVNISA----------TSL 408

  Fly   367 HWTWFSPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYLVEIVP--NQLN 429
            ...|....|.......|.:.:.|     |..:.|:...|..|:...|.....|.:.:.|  ..:.
Human   409 TLIWKVSDNESSSNYTYKIHVAG-----ETDSSNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIE 468

  Fly   430 GSAGTKYQEQST----VGEDQPSVIQDPVV-------EAEAYSMEVSWKTPEYADLCIDGYRLSG 483
            |:.|  :.:..|    |.:.:.:|:....:       :||::.|.:   |.|.|
Human   469 GTPG--FLQVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHI---TQEGA----------- 517

  Fly   484 WMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVET-KAAIVDY 547
               .:..||     |||..:.::  ..|.....|..:|:|......:|..|.|...| .:|:.|.
Human   518 ---GNSRVE-----ITTNQSIII--GGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDI 572

  Fly   548 -------TKVKLEMK--NAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHS 603
                   |::.|:.|  :..||::..:...:.:.::                   :...|.:..:
Human   573 HVVYVTTTEMWLDWKSPDGASEYVYHLVIESKHGSN-------------------HTSTYDKAIT 618

  Fly   604 KQGFNASLSPLSPYATYVCKVILYNVAGPSEPVVD---ADMHTTTYF--PEQPESVMLEKSTVSS 663
            .||       |.|..       |||:.  ..|.||   .|.::|..:  |....::.:..:|.::
Human   619 LQG-------LIPGT-------LYNIT--ISPEVDHVWGDPNSTAQYTRPSNVSNIDVSTNTTAA 667

  Fly   664 LLFNWQ-----PPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETK-------GDPSVN 716
            .| :||     .|||                 ||     |.::|:...|...       |.....
Human   668 TL-SWQNFDDASPTY-----------------SY-----CLLIEKAGNSSNATQVVTDIGITDAT 709

  Fly   717 FTGLAPAVRYMMQVAAQNDFGMGVYT-EPVIG----ITLPAVSDSVTQLTVLTQGPVNNNAVYEA 776
            .|.|.|...|.:::.||  .|.|:.: ||  |    .|.|| |.:.....|:.:.|.
Human   710 VTELIPGSSYTVEIFAQ--VGDGIKSLEP--GRKSFCTDPA-SMASFDCEVVPKEPA-------- 761

  Fly   777 NVTITWKVPCKSNGDIEYFQL-AFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDYT 840
             :.:.|..|..:|..   |:| ..:|..||        ...|::.:.:....|........|..:
Human   762 -LVLKWTCPPGANAG---FELEVSSGAWNN--------ATHLESCSSENGTEYRTEVTYLNFSTS 814

  Fly   841 VEVSVKNRDVEQLSSSVPGSWQS-------PAGLPTIP--SDELIKQMRANVEETSNPTKTAIVR 896
            ..:|:......::::....:..:       |.|.|.|.  |...:|...:..|.:..|.|...|
Human   815 YNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFSGFEASHGPIKAYAV- 878

  Fly   897 LPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSY-QEAGADGTGDCSLEYQ-TT 959
                |:|:..               ||.|      |:|   ||.| .|....|..|..:.|. .|
Human   879 ----ILTTGE---------------AGHP------SAD---VLKYTYEDFKKGASDTYVTYLIRT 915

  Fly   960 EERWHPEPVQRQRRDGEVTSDEEIV----FTIGLDKCSEVQKTYCNGPLLPDTDYNVVVRLFT-- 1018
            ||:      .|.:...||...|..|    .|:|          |.||.|.|...|...|..||
Human   916 EEK------GRSQSLSEVLKYEIDVGNESTTLG----------YYNGKLEPLGSYRACVAGFTNI 964

  Fly  1019 ------------------ASGYSDAAVLNFKTKAAIKVTLILVSVCSCLLLAFVL---GLTVLWV 1062
                              .|.||||..|      .....:|..:|..|:..|.|:   |..:.|.
Human   965 TFHPQNKGLIDGAESYVSFSRYSDAVSL------PQDPGVICGAVFGCIFGALVIVTVGGFIFWR 1023

  Fly  1063 RKRLAWKRDSGQGIEDPFGNVIAKNFAIFYTEVAKPEK-----------------------LARE 1104
            :||    :|             |||..:.:::: ||:|                       .|.|
Human  1024 KKR----KD-------------AKNNEVSFSQI-KPKKSKLIRVENFEAYFKKQQADSNCGFAEE 1070

  Fly  1105 FKEITVVALELSYSASELGCH--KNRYADIFPYDKNRVILDIDAEGS-DYINASFIDGHTRKKEY 1166
            ::::.:|.:.....|:||..:  ||||.::.|||.:||.|.:....: |||||:::.|:..||::
Human  1071 YEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISRVKLSVQTHSTDDYINANYMPGYHSKKDF 1135

  Fly  1167 IATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP----YNVRGLTVTIKSKEVL 1227
            ||||||.|.::.|||||:.:.||..|:.:|:..|....||.||:|    .:...:||.:.|:.||
Human  1136 IATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSEIVL 1200

  Fly  1228 ELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVK--AEKRPSYSPIVVHC 1290
            ..:...:.||.:.:......:..::|..|||||||:....||.|...|:  .::.|..|||:|||
Human  1201 PEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHC 1265

  Fly  1291 SAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIP 1355
            |||||||||||.:|.::.::::|:.::::..|..||..|..||||:.||.||..|..::|:   .
Human  1266 SAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVR---S 1327

  Fly  1356 RAALKMDGRPKSVTVPAIPSPKKVSFPDVDVGSEYVSSAPIT 1397
            :...|:|...::.|...|                |.:.||:|
Human  1328 QKDSKVDLIYQNTTAMTI----------------YENLAPVT 1353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	25/117 (21%)
		PTPc	1100..1345	CDD:214550	98/276 (36%)
		PTPc	1125..1348	CDD:238006	92/231 (40%)
PTPRJ	XP_016873572.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810