Protein Alignment Ptp52F and PTPRH

DIOPT Version :9

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_016882545.1
• Gene: PTPRH / 5794
• HGNCID: 9672
• Length: 1137
• Species: Homo sapiens
• Alignment Length: 1374
• Identity: 306/1374 - (22%)
• Similarity: 511/1374 - (37%)
• Gaps: 424/1374 - (30%)

  Fly   129 PKTTVTSVVATANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQTFVNLSACLTHTI 193
            |...:|....|.::|.::|:..|.                     |:.::|..:|.   |.....
Human    54 PGRNLTVETQTTSSISLSWEVPDG---------------------LDSQNSNYWVQ---CTGDGG 94

  Fly   194 TLDTRNNASVVVDTDATDVDTQYAEPGDLVMNVTNLASGITMITWGDPSEKNCISNYVFKWQRND 258
            |.:|||       |.||:|......||.|          .|...|   .||:.:::.|
Human    95 TTETRN-------TTATNVTVDGLGPGSL----------YTCSVW---VEKDGVNSSV------- 132

  Fly   259 CGTDQNQDTTTDVPSTETTNEIDYVTTTPMETT---PDTPSDEVKCEWTDVSSDG---KLREYLL 317
             ||    .||...|:......::..|.:.:..|   ||.|..:......:.:.||   ..|....
Human   133 -GT----VTTATAPNPVRNLRVEAQTNSSIALTWEVPDGPDPQNSTYGVEYTGDGGRAGTRSTAH 192

  Fly   318 TDL------QGCDLYTFQVFINEN--STAKASQTFTSAEKLVSAVYEPSPTAYPTQLHW---TWF 371
            |::      .|| ||.|.:::.:|  ::::.::..|:|...|..:...:.|.....|.|   ...
Human   193 TNITVDGLEPGC-LYAFSMWVGKNGINSSRETRNATTAHNPVRNLRVEAQTTSSISLSWEVPDGT 256

  Fly   372 SPQNHPKCVANYSVTLTGPIQRSENKTMNVITEETFAIFDDLDPCGIYL--VEIVPNQLNGSAGT 434
            .|||     :.|.|..||...|:|.:.    |.:|....|.|.|..:|.  |.:..:.:|.|.
Human   257 DPQN-----STYCVQCTGDGGRTETRN----TTDTRVTVDGLGPGSLYTCSVWVEKDGVNSSV-- 310

  Fly   435 KYQEQSTVGEDQPSVIQDPVVEAEA-YSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVEALSI 498
                :.......|:.:::..|||:. .|:.::|:.|:..|
Human   311 ----EIVTSATAPNPVRNLTVEAQTNSSIALTWEVPDGPD------------------------- 346

  Fly   499 TTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFID 563
             .||:|            |.::   ||     |...:.|..:.|    :|.:.::....|
Human   347 -PQNST------------YGVE---YT-----GDGGRAGTRSTA----HTNITVDRLEPG----- 381

  Fly   564 LIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNASLSPLSPYATYVCKVILYN 628
                       |..:|:::.                   .|.|.|:|
Human   382 -----------CLYVFSVWV-------------------GKNGINSS------------------ 398

  Fly   629 VAGPSEPVVDADMHTTTYFPEQPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYF 693
                      .:....|..|....::.:|..|.||:...|:.|   :||  |.|.:      :|:
Human   399 ----------RETRNATTAPNPVRNLHMETQTNSSIALCWEVP---DGP--YPQDY------TYW 442

  Fly   694 VPADCAIVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVT 758
            |.........:|::.|  :.||....|.|...|...|.|:.:...|...    .:::..|.::||
Human   443 VEYTGDGGGTETRNTT--NTSVTAERLEPGTLYTFSVWAEKNGARGSRQ----NVSISTVPNAVT 501

  Fly   759 QLTVLTQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELD--TGN 821
            .|:  .|...|      :.:.:.|..| :..|...|...           ||:.|....|  |.:
Human   502 SLS--KQDWTN------STIALRWTAP-QGPGQSSYSYW-----------VSWVREGMTDPRTQS 546

  Fly   822 KQGRMSYTETEMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEET 886
            ..| ...|..|::....|.:.|..:..:|...:|::..:        |.|::         |.:.
Human   547 TSG-TDITLKELEAGSLYHLTVWAERNEVRGYNSTLTAA--------TAPNE---------VTDL 593

  Fly   887 SNPTKTAIVRLPADIMTSASGD------IKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAG 945
            .|.|:|   :....:...|.||      :.|:     |....|.|....|..::|....|
Human   594 QNETQT---KNSVMLWWKAPGDPHSQLYVYWV-----QWASKGHPRRGQDPQANWVNQTS----- 645

  Fly   946 ADGTGDCSLEYQTTEERWHP----EP-------VQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTY 999
                        .|.|.|:.    ||       |..:|.|  |.|..:.:       |:   .||
Human   646 ------------RTNETWYKVEALEPGTLYNFTVWAERND--VASSTQSL-------CA---STY 686

  Fly  1000 CNGPLLPDTDYNVVVRLFTASGY---------------------------------SDAAVLNFK 1031
                  ||| ..:...:.|::||                                 ...:||...
Human   687 ------PDT-VTITSCVSTSAGYGVNLIWSCPQGGYEAFELEVGGQRGSQDRSSCGEAVSVLGLG 744

  Fly  1032 TKAAIKVTLILV----------SVC-------------SCLLLAFVLGLTVLWVRKRLAWKRDSG 1073
            ...:...|:..:          .||             ..||...::||.:.::::|...|:...
Human   745 PARSYPATITTIWDGMKVVSHSVVCHTESAGVIAGAFVGILLFLILVGLLIFFLKRRNKKKQQKP 809

  Fly  1074 QGIEDPF---GNVIAKNFAIFYTEVAKPEK-----LAREFKEITVVA---LELSYSASELGCHKN 1127
            :..:..|   |::.|::||   ..|.|.|:     .|.|::::::|.   .::..||||... ||
Human   810 ELRDLVFSSPGDIPAEDFA---DHVRKNERDSNCGFADEYQQLSLVGHSQSQMVASASENNA-KN 870

  Fly  1128 RYADIFPYDKNRVIL-DIDAE-GSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVR 1190
            ||.::.|||.:||.| .|..| |||||||||:.|....:|:||||||.|::|.||||::.:....
Human   871 RYRNVLPYDWSRVPLKPIHEEPGSDYINASFMPGLWSPQEFIATQGPLPQTVGDFWRLVWEQQSH 935

  Fly  1191 VIVQVTQFREGNTIKCHEYYPYNVRGLT-----VTIKSKEVLELYDRTELTV--VHDKYGLKEKV 1248
            .:|.:|...|...:||..|:|.:.:..|     ||:..:||:|.:...||.:  |.::..|..:.
Human   936 TLVMLTNCMEAGRVKCEHYWPLDSQPCTHGHLRVTLVGEEVMENWTVRELLLLQVEEQKTLSVRQ 1000

  Fly  1249 IHYYFKKWPDHGVPEDPMHLIMFVKKVK--AEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLK 1311
            .||  :.|||||||..|..|:.|.:.::  .::.....|.:||||||||||||.|.||:::::|:
Human  1001 FHY--QAWPDHGVPSSPDTLLAFWRMLRQWLDQTMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQ 1063

  Fly  1312 SESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPRAALKMDGRPKSVTVPAIPSP 1376
            ||..:..|..|:|:|..|..||||:.||.||:.|....::              :|...||   .
Human  1064 SEGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCILRFLQ--------------QSAQAPA---E 1111

  Fly  1377 KKVSFPDVD 1385
            |:|.:.||:
Human  1112 KEVPYEDVE 1120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	23/100 (23%)
		PTPc	1100..1345	CDD:214550	103/263 (39%)
		PTPc	1125..1348	CDD:238006	97/233 (42%)
PTPRH	XP_016882545.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810