Protein Alignment Ptp52F and PTPRG

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: XP_016862450.1
• Gene: PTPRG / 5793
• HGNCID: 9671
• Length: 1485
• Species: Homo sapiens
• Alignment Length: 1185
• Identity: 260/1185 - (21%)
• Similarity: 431/1185 - (36%)
• Gaps: 302/1185 - (25%)

  Fly   387 LTGPIQRSENKTMNVITEETFAIF--DDLDPCGIYL--------VEIVPNQLNGSAGTKYQEQST 441
            |.|....|.|||....|.:|.||.  ||....|..|        ||......|||||:   |.|.
Human   104 LDGFDNESSNKTWMKNTGKTVAILLKDDYFVSGAGLPGRFKAEKVEFHWGHSNGSAGS---EHSI 165

  Fly   442 VGEDQPSVIQDPVVEAE-AYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVEALSITTQN--- 502
            .|...|       |||| |...::.....:.....:.|.:...:.|.......:::.|...|
Human   166 NGRRFP-------VEAEDARGGDIMLMLSQGMRFILLGLKKEQFEERKSWTTYQSMQIFFYNPDD 223

  Fly   503 ----TTVVFDKNLLACQVYIIQIIPYTKENLD---GQLRQVGVETKAAIVD-YTKVKLEMKNAG- 558
                .|.:.:..::.......|:.|.....||   ..|:.|....|...:| :....|...:.|
Human   224 FDSFQTAISENRIIGAMAIFFQVSPRDNSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPASLGS 288

  Fly   559 -------------SEFIDLIAFNADYNNSCPTIFALFTCNATTQ---------VRNPYA------ 595
                         ||.::.|.|......|...:.|.::...|.|         :||.:.
Human   289 YYRYTGSLTTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLH 353

  Fly   596 ERYVEGHS-KQGFNASL-----SPLSPYATYVCKVILYNVAGPSEPVVDADMHTTTYFPEQPESV 654
            :|.|...: :..:|..:     :||...|:.||          |.|               |..:
Human   354 DRVVSKSAVRDSWNHDMTDFLENPLGTEASKVC----------SSP---------------PIHM 393

  Fly   655 MLEKSTVSSLLFNW-QPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKSETKGDPSVNFT 718
            .::....::|..:| ||.|..:.||       |.:..||....:....|:....::..|.....:
Human   394 KVQPLNQTALQVSWSQPETIYHPPI-------MNYMISYSWTKNEDEKEKTFTKDSDKDLKATIS 451

  Fly   719 GLAPAVRYMMQVAA------QNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQGPVNNNAVYEAN 777
            .::|...|:.:|.|      ::||..                      |:|.|  .|...:::..
Human   452 HVSPDSLYLFRVQAVCRNDMRSDFSQ----------------------TMLFQ--ANTTRIFQGT 492

  Fly   778 VTITWKVPC---KSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTETEMQPQFDY 839
            ..:...||.   .|:.|:.......:...::..|.||   |.:.||     |..:.:..|.
Human   493 RIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSF---VSMATG-----MGPSSSGSQA---- 545

  Fly   840 TVEVSVKNRDVEQLS------SSVPGS-WQSPAGLPTI--PSDELIKQMRANVEETSNPTKTAIV 895
            ||...|.:..:..|.      ||.|.: |  |..|||.  .|.:..:.:.|..|..::|
Human   546 TVASVVTSTLLAGLGFGGGGISSFPSTVW--PTRLPTAASASKQAARPVLATTEALASP------ 602

  Fly   896 RLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQT-- 958
                    ...||..      ..|:..|....:.|..|:...  ..:|...||..|...:.::
Human   603 --------GPDGDSS------PTKDGEGTEEGEKDEKSESED--GEREHEEDGEKDSEKKEKSGV 651

  Fly   959 ---TEERWHPEPVQRQ-------------------------------RRDGEVTSDEEIVFTIGL 989
               .|||...||....                               |||.....|.::|.:..:
Human   652 THAAEERNQTEPSPTPSSPNRTAEGGHQTIPGHEQDHTAVPTDQTGGRRDAGPGLDPDMVTSTQV 716

  Fly   990 DKCSEVQKTYCNGPLLPDTDYNVVV----RLFTASGYSDAAVLNFKTKAAIK----------VTL 1040
            ...:..::...:.|..|:......:    |....|.:.........|...|.          :.|
Human   717 PPTATEEQYAGSDPKRPEMPSKKPMSRGDRFSEDSRFITVNPAEKNTSGMISRPAPGRMEWIIPL 781

  Fly  1041 ILVSVCSCLLLAFVLGLTVLW----------VRKRLAWKRDSGQG---------------IEDPF 1080
            |:||..:.:.|..::.:.|.|          ..:|......||:.               :||..
Human   782 IVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSS 846

  Fly  1081 GNVIAKNFAIFYTEV-----AKPEK----------------LAREFKEITVVALELSYSASEL-- 1122
            ...:..|.:|....:     |.|.|                .:.:|:|:.....:::.:|...
Human   847 SPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNH 911

  Fly  1123 --GCHKNRYADIFPYDKNRVIL----DIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFW 1181
              ..|||||.:|..||.:||.|    ..|::.||||||:::||:.:.|.|||||||...:..|||
Human   912 PENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFW 976

  Fly  1182 RMILQYNVRVIVQVTQFREGNTIKCHEYYP------YNVRGLTVTIKSKEVLELYDRTELTVVHD 1240
            |||.:.|..:||.:|...|....||.:|:|      |.  .:.||:||.::...|.....::.:.
Human   977 RMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYG--NIIVTLKSTKIHACYTVRRFSIRNT 1039

  Fly  1241 KYGLKEK-----------VIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGV 1294
            |....:|           ||.|::.:|||.||||..:.::.||::..|.:.|...|::|||||||
Human  1040 KVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGV 1104

  Fly  1295 GRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPR-AA 1358
            |||||:|.:|.::|::|.:|.:|:...:|.:|.||..:|||::||.|::....|.:..|... ::
Human  1105 GRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSS 1169

  Fly  1359 LKMDGRPKSVTVPAI 1373
            .::.....|:.:|.:
Human  1170 NQLHSYVNSILIPGV 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	19/107 (18%)
		PTPc	1100..1345	CDD:214550	98/285 (34%)
PTPRG	XP_016862450.1	alpha_CARP_receptor_like	67..359	CDD:239396	57/264 (22%)
		FN3	388..478	CDD:238020	20/133 (15%)
		PHA03169	<584..>742	CDD:223003	26/179 (15%)
		R-PTPc-G-1	888..1161	CDD:350505	98/274 (36%)
		R-PTP-G-2	1245..1449	CDD:350508