DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and PTPRD

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_001364887.1	Gene:	PTPRD / 5789	HGNCID:	9668	Length:	1932	Species:	Homo sapiens

Alignment Length:	1448	Identity:	324/1448 - (22%)
Similarity:	548/1448 - (37%)	Gaps:	363/1448 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PKTTVTSVV--ATANTIKVTWQTNDRACVESFGITAKATDYTKSFQLLNDKSSQTF--VNLSACL 189
            ||...|.||  :||.:|.:||.:.:...|..:.|..|..:..:.::.::..::..:  ..||...
Human   323 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387

  Fly   190 THTITLDTRNNASVVVDTDATDVDTQYAEPGDLVMNV--TNLASGITMITWGDPSEKN-CISNY- 250
            .:...:...||......::.....|....|.....:|  ..|:|...::.|.:|.|.| .|..|
Human   388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 452

  Fly   251 ----------VFKWQRNDCGTDQNQDTT-----------------TDVPSTETTNEIDYVTTT-- 286
                      |..|.:::..  .:|.||                 |.:.....:::|..:|.|
Human   453 VYYTMDPTQHVNNWMKHNVA--DSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGV 515

  Fly   287 ---PMETTPDTPSD-EVKCEWTD-----------VSSDGKLRE-----------YLLTDLQGCDL 325
               |:....:..|: .:...||.           |..||:..|           |.|..|:...|
Human   516 PGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSL 580

  Fly   326 YTFQVFINENSTAKASQTFTSAEKLVSA-VYEPSPTAYPTQLHWT----------WFSP--QNHP 377
            |.|::      .|::.|...::...:|| ..:..|:|.|..:..|          |..|  :...
Human   581 YYFRL------AARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQN 639

  Fly   378 KCVANYSVTLTGPIQRSENKTMNVI---TEETFAIFDDLDPCGIYLVEIVPNQLNGSAGTKYQEQ 439
            ..:..||:..|. :...::|...::   ::.|..:.:.|:....|.:.:..:...|.........
Human   640 GIITEYSIKYTA-VDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVL 703

  Fly   440 STVGEDQPSVIQDP--VVEAEAY---SMEVSWKTP----EYADLCIDGYRL-------------- 481
            ....||.||   .|  .||.||.   |::|||::|    ::..  |.||::
Human   704 IRTNEDVPS---GPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQ--IRGYQVHYVRMENGEPKGQP 763

  Fly   482 ---------SGWMEDDKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLRQVG 537
                     :.|..||          ||::..::  ..|.....|.:.:..||.:....:.:...
Human   764 MLKDVMLADAQWEFDD----------TTEHDMII--SGLQPETSYSLTVTAYTTKGDGARSKPKL 816

  Fly   538 VETKAA-------IVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYA 595
            |.|..|       ::::|    :|..|      ||.::...:...|
Human   817 VSTTGAVPGKPRLVINHT----QMNTA------LIQWHPPVDTFGP------------------- 852

  Fly   596 ERYVEGHSKQGFNASLSPLSPY-----------------ATYVCKVILYNVAGPSEPVVDADMHT 643
               ::|:..:.....:.||:..                 |:||.::...|..|..|     :|..
Human   853 ---LQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGE-----EMVK 909

  Fly   644 TTYFPEQ-----PESVMLEKSTVSSLLFNWQPPTYT--NGPIKYYQAFLMRHEASYFVPADCAIV 701
            ....||:     |:::..|.:|.:|:..:||||...  ||.|..| ..|.|......:|.:..||
Human   910 EISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKY-TLLYRDINIPLLPMEQLIV 973

  Fly   702 EQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLTQG 766
            ..||        ::..|||.|...|.::|.|....|.|.|:..|...|||     |.|.......
Human   974 PADT--------TMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLP-----VDQAVFAKNF 1025

  Fly   767 PVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYTET 831
            .|  .||.:.:|.::|::|...|..:.:..|..:|           :.||...|....::.   .
Human  1026 HV--KAVMKTSVLLSWEIPENYNSAMPFKILYDDG-----------KMVEEVDGRATQKLI---V 1074

  Fly   832 EMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAIVR 896
            .::|:..|:..::  ||      .:..|..|......|.|  ::::...|.:.:| |......|:
Human  1075 NLKPEKSYSFVLT--NR------GNSAGGLQHRVTAKTAP--DVLRTKPAFIGKT-NLDGMITVQ 1128

  Fly   897 LPADIMTSASGDIK-WMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTE 960
            ||.   ..|:.:|| :..:::..|...|    |:....:.|..:...|.
Human  1129 LPE---VPANENIKGYYIIIVPLKKSRG----KFIKPWESPDEMELDEL---------------- 1170

  Fly   961 ERWHPEPVQRQRRDGEVTSDEEI-------------VFTIGLDKCSEVQKTYCNGPLLPDTDYNV 1012
                .:.:.|:||......:.|:             .||:|.||   ....:.|..|....:|..
Human  1171 ----LKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDK---HYGGFTNKQLQSGQEYVF 1228

  Fly  1013 VV---------RLFTASGYSDAAV--------LNFKTKAAIKVT--LILVSVCSCLLLAFVLGLT 1058
            .|         :::..|.|||..|        :..:.:..|.|.  ::.|....|:::|.:|..:
Human  1229 FVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKS 1293

  Fly  1059 VLWVRKRLAWKRDSGQGI------------EDPF------------------GNVIAKNFAIF-- 1091
            ....|||.  :.||.:..            .||.                  ||:.:.:.|..
Human  1294 SKPDRKRA--ESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGSDDSGYPGNLHSSSMASHPP 1356

  Fly  1092 --------YTEVAKPE---KLAREFKEITV-VALELSYSASELGCHKNRYADIFPYDKNRVILDI 1144
                    :.|..|..   |.::|::.|.. ......:|..|:...|||||::..||.:||:|..
Human  1357 IPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSA 1421

  Fly  1145 --DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCH 1207
              ...||||:||::|||:.::..||||||..||:..||||||.:.....:|.:|:..|.:.:||.
Human  1422 IEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCD 1486

  Fly  1208 EYYP---YNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEK--VIHYYFKKWPDHGVPEDPMH 1267
            :|:|   ....|| |.:...:.:||......|....|.|..||  |..:.|..||||||||.|..
Human  1487 QYWPSRGTETHGL-VQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTP 1550

  Fly  1268 LIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKM 1332
            .:.|:::||....|...|:||||||||||||.||.:|.:::|:|.|..::|:..|..:|.||..|
Human  1551 FLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYM 1615

  Fly  1333 VQTQQQYTFLYACTYELV 1350
            |||:.||.|::....|.|
Human  1616 VQTEDQYIFIHDALLEAV 1633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	32/107 (30%)
		PTPc	1100..1345	CDD:214550	101/252 (40%)
		PTPc	1125..1348	CDD:238006	96/229 (42%)
PTPRD	NP_001364887.1	I-set	24..115	CDD:400151
		Ig strand A'	32..36	CDD:409353
		Ig strand B	39..48	CDD:409353
		Ig strand C	54..59	CDD:409353
		Ig strand C'	62..65	CDD:409353
		Ig strand D	68..75	CDD:409353
		Ig strand E	76..86	CDD:409353
		Ig strand F	94..102	CDD:409353
		Ig strand G	105..115	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	127..226	CDD:409400
		Ig strand B	143..147	CDD:409400
		Ig strand C	156..160	CDD:409400
		Interaction with IL1RAPL1. /evidence=ECO:0000250	180..189
		Mini-exon peptide A9, sufficient for interaction with IL1RAPL1. /evidence=ECO:0000250\|UniProtKB:Q64487	181..189
		Ig strand E	190..194	CDD:409400
		Ig strand F	204..209	CDD:409400
		Ig strand G	216..219	CDD:409400
		Mini-exon peptide B, required for interaction with SLITRK2 and in the function in pre-synaptic differentiation, Acts as an adjustable linker to control relative positions and orientations of the PTPRD second and third immunoglobilin domains for their simultaneous interactions with the first immunoglobilin domain of IL1RAPL1 and IL1RAP, Modulates affinity for IL1RAPL1 and IL1RAP. /evidence=ECO:0000250\|UniProtKB:Q64487	227..230
		IgI_3_RPTP_IIa_LAR_like	239..320	CDD:409401
		Ig strand B	253..257	CDD:409401
		Ig strand C	266..270	CDD:409401
		Ig strand E	287..291	CDD:409401
		Ig strand F	299..304	CDD:409401
		Ig strand G	312..315	CDD:409401
		FN3	323..412	CDD:238020	17/88 (19%)
		FN3	419..511	CDD:238020	16/93 (17%)
		FN3	516..604	CDD:238020	18/93 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..623		4/19 (21%)
		FN3	612..706	CDD:238020	12/94 (13%)
		FN3	713..819	CDD:238020	23/119 (19%)
		FN3	824..919	CDD:238020	18/131 (14%)
		FN3	922..1013	CDD:238020	30/99 (30%)
		FN3	1023..>1084	CDD:238020	14/76 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1304..1324		2/19 (11%)
		R-PTPc-D-1	1354..1637	CDD:350472	105/281 (37%)
		Substrate binding. /evidence=ECO:0000250	1573..1579		5/5 (100%)
		R-PTP-D-2	1638..1929	CDD:350476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010