DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp52F and PTPRB

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	XP_006719591.1	Gene:	PTPRB / 5787	HGNCID:	9665	Length:	2230	Species:	Homo sapiens

Alignment Length:	1597	Identity:	345/1597 - (21%)
Similarity:	591/1597 - (37%)	Gaps:	375/1597 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 TNWKQSHRRI--HALILILWIAGVQGQTV--------------GSLVAV---------SESQELA 43
            |||.|:...:  :.::||.....::.:::              |||.:|         |..|.:.
Human   791 TNWTQAQGDVEFYQVLLIHENVVIKNESISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVV 855

  Fly    44 EKVEVTVVSTVYTLGFSISNEADYSIDKVICRNGSGSETEANAAH---------VCENLNPCTF- 98
            |  ..||.|:|..:..:.|...||.....:...|.....|...:|         :.:::..|:|
Human   856 E--GRTVPSSVSGVTVNNSGRNDYLSVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFS 918

  Fly    99 -------YTSVVSFRSNVSGKPPPSDQTIYAYTEYKQPKTTVTSV--VATANT-----IKVTW-- 147
                   ||..::.|   |||        |....:.|.:|....|  |:.:|:     ::|:|
Human   919 SLTPGRLYTVTITTR---SGK--------YENHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVH 972

  Fly   148 QTNDRACVESFGITAK-ATDYTKSFQLLNDKSSQTFVNLSACLTHTITLDTRNNASVVVDTDATD 211
            .|.|   .:.:.:|.| ..::.::..:...::...||.|.....:::|:.|::.
Human   973 ATGD---FDHYEVTIKNKNNFIQTKSIPKSENECVFVQLVPGRLYSVTVTTKSG----------- 1023

  Fly   212 VDTQY-----------AEP-GDLVMNVTNLASGITMITW----GDPSEKNCISNYVFKWQRNDCG 260
               ||           .|| .||.:.  |.::....:||    ||      :..|..:...||
Human  1024 ---QYEANEQGNGRTIPEPVKDLTLR--NRSTEDLHVTWSGANGD------VDQYEIQLLFND-- 1075

  Fly   261 TDQNQDTTTDVPSTETTNEIDYVTTTP--------------------------------METTPD 293
                ...........|..|..:.:.||                                :..:|:
Human  1076 ----MKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAFIEGFTVPSAVKNIHISPN 1136

  Fly   294 TPSDEVKCEWTDVSSDGKLREYLLTDLQGCDLYTFQVFINENSTAKASQTFT------------- 345
            ..:|.:...||....|             .|.||...|  .:|....|||..
Human  1137 GATDSLTVNWTPGGGD-------------VDSYTVSAF--RHSQKVDSQTIPKHVFEHTFHRLEA 1186

  Fly   346 -------------SAEKLVSAVYEPSP------------TAYPTQLHWTWFSPQNHPKCVANYSV 385
                         |.:..::.|....|            ::|...:.|     |........|.:
Human  1187 GEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSW-----QKAAGVAERYDI 1246

  Fly   386 TLTGPIQRSENKTMNVITEETFAI----FDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQ 446
            .|.     :||..:...|.|....    |:||.|...|.::|    |..|.|...:|..|.|...
Human  1247 LLL-----TENGILLRNTSEPATTKQHKFEDLTPGKKYKIQI----LTVSGGLFSKEAQTEGRTV 1302

  Fly   447 PSVIQD-PVVEAEAYSMEVSWKTPEYADLCIDGYRLSGWMEDDKLVEVEALSITTQNTTVVFDKN 510
            |:.:.| .:.|.....:...|...|..   :..|.:..:..|..|.|...:....|:.:.   :|
Human  1303 PAAVTDLRITENSTRHLSFRWTASEGE---LSWYNIFLYNPDGNLQERAQVDPLVQSFSF---QN 1361

  Fly   511 LLACQVYIIQIIPYTKENLDGQLRQVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAFN-----AD 570
            ||..::|.:.|:.::.| |..:....|....|::       ..::.:.....|.:.||     .|
Human  1362 LLQGRMYKMVIVTHSGE-LSNESFIFGRTVPASV-------SHLRGSNRNTTDSLWFNWSPASGD 1418

  Fly   571 YNNSCPTIFALFTCNATTQVRNPYAERYVEGHSKQGFNASLSPLSPYATYVCKVILYNVAGPSEP 635
            ::     .:.|...|.....:..:.::.:.....||       |.|...||..|:.:  :|....
Human  1419 FD-----FYELILYNPNGTKKENWKDKDLTEWRFQG-------LVPGRKYVLWVVTH--SGDLSN 1469

  Fly   636 VVDADMHTTTYFPEQPESVMLEKSTVSSLLFNWQ-PPTYTNGPIKYYQAFLMRHEASYFVPADCA 699
            .|.|:..|.   |..|..:.......:||...|: ||.:|:     |..|.::     ::|.| |
Human  1470 KVTAESRTA---PSPPSLMSFADIANTSLAITWKGPPDWTD-----YNDFELQ-----WLPRD-A 1520

  Fly   700 IVEQDTKSETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIGITLPAVSDSVTQLTVLT 764
            :...:..:..|.:..:.: ||.|...|...|...:......|::|:.|    :|.....::..|.
Human  1521 LTVFNPYNNRKSEGRIVY-GLRPGRSYQFNVKTVSGDSWKTYSKPIFG----SVRTKPDKIQNLH 1580

  Fly   765 QGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVELDTGNKQGRMSYT 829
            ..|.|:.|     :..:|..|     |.::...:....:.:...|.|.|::|.:.......|
Human  1581 CRPQNSTA-----IACSWIPP-----DSDFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMM--- 1632

  Fly   830 ETEMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPTKTAI 894
               :.|...|.  ||:|.:.....|..|..|..:....|..|...:    |.|.::......:..
Human  1633 ---LVPHKRYL--VSIKVQSAGMTSEVVEDSTITMIDRPPPPPPHI----RVNEKDVLISKSSIN 1688

  Fly   895 VRLPADIMTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLE-YQT 958
            ..:.....:..:|.:|:..:::.:.:  |...||.:.....|..|.|:.       :.|:. |||
Human  1689 FTVNCSWFSDTNGAVKYFTVVVREAD--GSDELKPEQQHPLPSYLEYRH-------NASIRVYQT 1744

  Fly   959 TEERWHPEPVQRQRRDGEVTSDEEIVFTIGL--------DKCSEVQKTYCNGPLLPDTDYNVVVR 1015
            .         ....:..|..:.....|.|.|        .||...|:.:|:|||.|.|.|.:.:|
Human  1745 N---------YFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPHTAYRISIR 1800

  Fly  1016 L-----------FTASGYSDAAV-LNFKTKA--------AIKVTLILVSVCSCLLLAFVLGLTVL 1060
            .           ||...|||... |...|::        .:...|.|:.:...::...:....|.
Human  1801 AFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAIEGVSAGLFLIGMLVAVVALLICRQKVS 1865

  Fly  1061 WVRK----RLAWKRDSGQGIEDPFGN---------VIAKNFAIFYTEVAKPEK--LAREFKEITV 1110
            ..|:    ||:.:||....:....|.         :....|...:.::.....  |::|::|:..
Human  1866 HGRERPSARLSIRRDRPLSVHLNLGQKGNRKTSCPIKINQFEGHFMKLQADSNYLLSKEYEELKD 1930

  Fly  1111 VALELSYSASEL--GCHKNRYADIFPYDKNRVIL-DIDAEG-SDYINASFIDGHTRKKEYIATQG 1171
            |....|...:.|  ...||||.:|.|||..||.| ::|.:. |||||||:|.|:..::|||.|||
Human  1931 VGRNQSCDIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQG 1995

  Fly  1172 PKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-----VRGLTVTIKSKEVLELYD 1231
            |.|.:..|||:|:.:.||..||.|||..|...:||..|:|.:     ...|.:.:.|:.||..:.
Human  1996 PLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWT 2060

  Fly  1232 RTELTVVHDKYGLKEKVI-HYYFKKWPDHGVPEDPMHLIMFVKKVK--AEKRPSYSPIVVHCSAG 1293
            ..|..:..::.....::| |:::..||||||||....||.||:.|:  ..:.|...|.|||||||
Human  2061 IREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAG 2125

  Fly  1294 VGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPRAA 1358
            ||||||||.||.|:|:|.|:..::|:..|..||..|:.||||:.||.:|:.|..::::      |
Human  2126 VGRTGTFIALDRILQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLR------A 2184

  Fly  1359 LKMDGRPKSVTVPAIPSPKKVSFPDVDVGSEYVSSAP 1395
            .|:....::   |..|..:.|: |:...|...:...|
Human  2185 RKLRSEQEN---PLFPIYENVN-PEYHRGGHLLHLLP 2217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	22/101 (22%)
		PTPc	1100..1345	CDD:214550	106/258 (41%)
		PTPc	1125..1348	CDD:238006	101/232 (44%)
PTPRB	XP_006719591.1	RICIN	<22..94	CDD:238092
		fn3	255..319	CDD:278470
		fn3	331..407	CDD:278470
		fn3	422..488	CDD:278470
		FN3	507..582	CDD:238020
		fn3	596..672	CDD:278470
		fn3	687..765	CDD:278470
		fn3	774..847	CDD:278470	10/55 (18%)
		fn3	862..938	CDD:278470	16/86 (19%)
		fn3	950..1026	CDD:278470	15/92 (16%)
		fn3	1039..1112	CDD:278470	15/86 (17%)
		fn3	1126..1199	CDD:278470	13/87 (15%)
		fn3	1216..1294	CDD:278470	18/91 (20%)
		fn3	1305..1378	CDD:278470	14/78 (18%)
		fn3	1394..1466	CDD:278470	13/92 (14%)
		fn3	1480..1562	CDD:278470	18/93 (19%)
		fn3	1574..1649	CDD:278470	17/92 (18%)
		PTPc	1920..2178	CDD:214550	106/257 (41%)
		PTPc	1947..2178	CDD:238006	100/230 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810