Protein Alignment Ptp52F and PTPRA

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 157/542 - (28%)
• Similarity: 236/542 - (43%)
• Gaps: 129/542 - (23%)

  Fly   868 PTIPSDELIKQMRAN-VEE---TSNPTKTAIVRLPADIMTSASGDIKWMALMISQKNCAGVPHLK 928
            |::....||....|. |:|   |||||.:         :||.|     :|...|.....|..:|.
Human    38 PSVGITRLINSSTAEPVKEEAKTSNPTSS---------LTSLS-----VAPTFSPNITLGPTYLT 88

  Fly   929 YDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCS 993
            ...|||          ..:||                         ....|...|..||.
Human    89 TVNSSD----------SDNGT-------------------------TRTASTNSIGITIS----- 113

  Fly   994 EVQKTYCNGPLLPDTDYN---------------VVVRLFTASGYSDAAVLNFKTKAAIKVTLILV 1043
                  .||..|||..:.               .....|..||.||:.....:|    .:..::|
Human   114 ------PNGTWLPDNQFTDARTEPWEGNSSTAATTPETFPPSGNSDSKDRRDET----PIIAVMV 168

  Fly  1044 SVCSCLLLAFVLGLTVLWVRKRLAWKRDSG------------QGIEDPFGNVIAKNFAI------ 1090
            ::.|.|::.|:  :.||::.:...:|:...            :.:|.....::|::.:.
Human   169 ALSSLLVIVFI--IIVLYMLRFKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPP 231

  Fly  1091 ---------FYTEVAKPEKLAR-EFKEITVVALELSYSAS--ELGCHKNRYADIFPYDKNRVILD 1143
                     ....:|...||.| ||..:....::.:..|:  |....||||.:|.|||.:||.|
Human   232 LPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHL- 295

  Fly  1144 IDAEG---SDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIK 1205
            ...||   |||||||||:|:..|.::||.||||.|:|.||||||.:.|...||.||..:|....|
Human   296 TPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECK 360

  Fly  1206 CHEYYP----YNVRGLTVTIKSKEVLELYDRTELTV--VHDKYGLKEK--VIHYYFKKWPDHGVP 1262
            |.:|:|    :....:.|:::...||..|...:..:  |.|....|.:  :..::|..|||.|||
Human   361 CAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVP 425

  Fly  1263 EDPMHLIMFVKKVKAEKRPSYS-PIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLR 1326
            ..|:.::.|:||||| ..|.|: .|||||||||||||||:.:|.::..:.:|.|::::..|.::|
Human   426 FTPIGMLKFLKKVKA-CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIR 489

  Fly  1327 FQRMKMVQTQQQYTFLYACTYE 1348
            .||.:||||..||.|:|....|
Human   490 AQRCQMVQTDMQYVFIYQALLE 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	108/259 (42%)
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	110/289 (38%)
		R-PTPc-A-2	574..801	CDD:350471