Protein Alignment Ptp52F and PTPN4

DIOPT Version :10

• Sequence 1: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Sequence 2: NP_002821.1
• Gene: PTPN4 / 5775
• HGNCID: 9656
• Length: 926
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 86/260 - (33%)
• Similarity: 137/260 - (52%)
• Gaps: 19/260 - (7%)

  Fly  1093 TEVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDIDAEGS-DYINASF 1156
            |.:.:.::|.|:...:|:...:|..:.|     ||||.||.|||..||||    :|: |||||::
Human   654 TVLTQFDQLYRKKPGMTMSCAKLPQNIS-----KNRYRDISPYDATRVIL----KGNEDYINANY 709

  Fly  1157 ID----GHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRGL 1217
            |:    ..:...:|||.|||.|.:..|||:|..:....::|.:|...|...:|||:|:|......
Human   710 INMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSS 774

  Fly  1218 T-----VTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKA 1277
            :     ||..|:|....|...::|:.:.:......:....:..|||||||:|....:.||..|:.
Human   775 SYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRN 839

  Fly  1278 EKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFL 1342
            ::.....|:|||||||:||||..|.::..|..::....:...:.|:.:|.||..|:||..||.|:
Human   840 KRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFV 904

  Fly  1343  1342
            Human   905  904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	85/253 (34%)
PTPN4	NP_002821.1	B41	30..222	CDD:214604
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010
		FA	324..365	CDD:462582
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..475
		PDZ_PTPN3-4-like	513..602	CDD:467190
		PTP_DSP_cys	641..914	CDD:475123	86/260 (33%)