DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp52F and ptpn22

DIOPT Version :9

Sequence 1:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster
Sequence 2:	NP_001092890.1	Gene:	ptpn22 / 565606	ZFINID:	ZDB-GENE-060503-458	Length:	887	Species:	Danio rerio

Alignment Length:	331	Identity:	111/331 - (33%)
Similarity:	161/331 - (48%)	Gaps:	43/331 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1126 KNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYN 1188
            ||||.||.|:|.:||.|.:  ....:||||||||.|.:..|.|||||||...:|:||||||.:||
Zfish    62 KNRYKDIVPFDHSRVKLSLFTSKNDTDYINASFIKGVSGSKAYIATQGPLSNTVLDFWRMIWEYN 126

  Fly  1189 VRVIVQVTQFREGNTIKCHEYYP------YNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEK 1247
            ::|||.|.:..|....||..|:|      :.....|:..:|.|....|....|.|...:...:.|
Zfish   127 IQVIVMVCREFEMGRKKCERYWPESKGDVFVCEAFTILYESDENKGDYLTRTLKVTFKQESRRLK 191

  Fly  1248 VIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKS 1312
            .:||.  .|||||||:....::..:::::..:.....||.:|||||.||||....:|.....||.
Zfish   192 QLHYV--NWPDHGVPDSIPAILELLQEMRIYQDNEEIPICIHCSAGCGRTGALCAIDYTWNLLKR 254

  Fly  1313 E---SKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPRAALKMDGRPKSVTVPAIP 1374
            :   ...:|||.||.:|.||..:|||::||..:|.....|.:..:  |||:    ..|..||...
Zfish   255 QIIPEDFSIFELVKGMRTQRPSVVQTKEQYELVYRTIKLLFERYL--AALE----APSNKVPDSS 313

  Fly  1375 SPKKVSFPDVDVGSEYVSSAPITDLDDGRPIVQLPSR--------FSGLRRNS-----PPGENDN 1426
            ||..:|           |.:.::|:.|.....|...|        ::.:.:||     |..:..:
Zfish   314 SPAMLS-----------SGSELSDISDFSDQEQTEHRNDEIRVDEYNHVMQNSASWQQPHSQTFS 367

  Fly  1427 PTSSSN 1432
            |...||
Zfish   368 PEVMSN 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	90/229 (39%)
		PTPc	1125..1348	CDD:238006	90/232 (39%)
ptpn22	NP_001092890.1	Y_phosphatase	59..291	CDD:278528	90/230 (39%)
ptpn22	NP_001092890.1	PTPc	61..291	CDD:238006	90/230 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910